The G protein Gα13 is frequently lost in germinal center (GC) B cell-derived lymphomas. Mice that lack Gα13 exhibit increased proliferation of GC B cells in gut-draining lymph nodes where they go on to develop lymphomas. Dietary glutamine drives the proliferation of mucosal GC B cells that lack Gα13, potentially explaining the gut tropism of these lymphomas..

G蛋白Gα13在生发中心（GC）B细胞衍生的淋巴瘤中经常丢失。缺乏Gα13的小鼠在肠道引流淋巴结中表现出GC B细胞增殖增加，并在那里发展为淋巴瘤。膳食谷氨酰胺驱动缺乏Gα13的粘膜GC B细胞的增殖，这可能解释了这些淋巴瘤的肠道趋向性。。

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Fig. 1: GC MYC expression is supported by dietary glutamine in the mLNs.

图1:MLN中的膳食谷氨酰胺支持GC-MYC表达。

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Download referencesAdditional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.This is a summary of: Nguyen, H. T. et al. Gα13 restricts nutrient driven proliferation in mucosal germinal centers.

下载参考其他信息出版商的注释Springer Nature对于已发布地图和机构隶属关系中的管辖权主张保持中立。这是Nguyen，H.T.等人的总结。Gα13限制粘膜生发中心中营养驱动的增殖。

Nat. Immunol. https://doi.org/10.1038/s41590-024-01910-0 (2024).Rights and permissionsReprints and permissionsAbout this articleCite this article Dietary glutamine supports mucosal germinal center B cell lymphomas..

自然免疫。https://doi.org/10.1038/s41590-024-01910-0（2024年）。权利和许可打印和许可本文引用本文膳食谷氨酰胺支持粘膜生发中心B细胞淋巴瘤。。

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