书蝎毒对医院细菌也有效-动脉网

Book scorpion venom also effective against hospital germs

D-Pharm 2024-08-09 12:18 翻译由动脉网AI生成，点击反馈

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The book scorpion (Chelifer cancroides), only a few millimetres long, is the best-known member of the pseudoscorpions, an order of arachnids, in Central Europe. It hunts house dust mites, bark lice and book lice in living spaces. It also kills pests in beehives. It often uses its venom to do so. For the first time, researchers in Hesse, Germany, have comprehensively characterised the components of this venom – and discovered molecules with a strong effect against so-called hospital germs.

书《蝎子》（Chelifer cancroides）只有几毫米长，是中欧蜘蛛目伪蝎子中最著名的成员。它在生活空间猎杀屋尘螨、树皮虱和书虱。它还能杀死蜂箱中的害虫。它经常用它的毒液来做这件事。德国黑森的研究人员首次全面表征了这种毒液的成分，并发现了对所谓的医院细菌具有强大作用的分子。

The results may help to combat difficult-to-treat infectious diseases in the future. A team of Hessian researchers from the LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG) and other institutions has now succeeded for the first time in artificially producing all known members of a family of toxins from the book scorpion (Chelifer cancroides) and investigating their activity.

该结果可能有助于未来对抗难以治疗的传染病。来自LOEWE转化生物多样性基因组学中心（LOEWE-TBG）和其他机构的Hessian研究人员团队现在首次成功地从《蝎子》（Chelifer cancroides）一书中人工产生了毒素家族的所有已知成员，并调查了它们的活动。

The scientists discovered a surprisingly strong activity against a well-known hospital germ called Methicillin-resistant Staphylococcus aureus (MRSA). Staphylococci are common bacteria that colonise the skin and mucous membranes. What makes MRSA variants special is that they are resistant to the antibiotic methicillin and therefore cause difficult-to-treat infections in humans, including after surgery.

科学家们发现了一种对众所周知的医院细菌——耐甲氧西林金黄色葡萄球菌（MRSA）具有惊人强的抗菌活性。葡萄球菌是定植于皮肤和粘膜的常见细菌。MRSA变体的特殊之处在于它们对抗生素甲氧西林具有耐药性，因此导致人类感染难以治疗，包括手术后感染。

The family of toxins analysed had been newly discovered in a previous study decoding the venom cocktail of the book scorpion and named “checacins”. In order to quickly and efficiently find out more about the mode of action of this previously unknown class of toxins, different working groups from the LOEWE Centre TBG tested the activity of the toxins against tumour formation, bacteria and inflammation in parallel – at the Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) in Fran.

分析的毒素家族是在之前的一项研究中新发现的，该研究解码了《蝎子》一书中的毒液混合物，并命名为“checacins”。为了快速有效地了解这类以前未知的毒素的作用方式，洛伊中心TBG的不同工作组在法国弗劳恩霍夫转化医学与药理学研究所（ITMP）同时测试了毒素对肿瘤形成，细菌和炎症的活性。

Original publication

原始出版物

Pelin Erkoc, Susanne Schiffmann, Thomas Ulshöfer, Marina Henke, Michael Marner, Jonas Krämer, Reinhard Predel, Till F. Schäberle, Sabine Hurka, Ludwig Dersch, Andreas Vilcinskas, Robert Fürst, Tim Lüddecke; 'Determining the pharmacological potential and biological role of linear pseudoscorpion toxins via functional profiling'; iScience, Volume 27.

佩林·埃尔科克（PelinErkoc）、苏珊·希夫曼（SusanneSchiffmann）、托马斯·乌尔什费尔（ThomasUlshöfer）、玛丽娜·亨克（MarinaHenke）、迈克尔·马纳（MichaelMarner）、乔纳斯·克鲁默（JonasKrämer）、莱茵哈德·普雷德尔（ReinhardPredel）、蒂尔·F·施贝尔（F.Schäberle）、萨宾·赫卡（SabineHurka）、通过功能分析确定线性伪蝎毒素的药理潜力和生物学作用；iScience，第27卷。

https://www.bionity.com/en/news/1184154/book-scorpion-venom-also-effective-against-hospital-germs.html

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