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A recent study identified insoluble, high molecular weight parkin aggregates in the substantia nigra of individuals with idiopathic Parkinson’s disease (PD). The research, spearheaded by Tremblay, Pshevorskiy, and Cottez, highlights a significant molecular occurrence within a brain region vital for motor control..

最近的一项研究在特发性帕金森病（PD）患者的黑质中发现了不溶性的高分子量帕金蛋白聚集体。这项由特伦布莱、普谢沃斯基和科特兹领导的研究强调了这一对运动控制至关重要的大脑区域中显著的分子现象。

The study, which appeared in npj Parkinson’s Disease, focused on analyzing brain tissue from PD patients. Researchers discovered that parkin, a protein typically involved in removing damaged proteins and maintaining cellular health, forms large, insoluble aggregates in the substantia nigra. This finding suggests that the accumulation of these parkin aggregates may disrupt normal cellular function and contribute to the development or progression of Parkinson’s disease..

该研究发表在《npj帕金森病》上，专注于分析帕金森病患者的大脑组织。研究人员发现，通常参与清除受损蛋白质并维持细胞健康的蛋白parkin，在黑质中形成了大块不溶性聚集体。这一发现表明，这些parkin聚集体的积累可能会破坏正常的细胞功能，并对帕金森病的发生或进展起到推动作用。

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Date: May 7, 2026

日期：2026年5月7日

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