Company's Cognitive Network Restoration Therapy (CNRT) technology aims to make meaningful cognitive recovery possible years after initial injury

公司的认知网络恢复疗法（CNRT）技术旨在使患者在初始损伤数年后仍能实现有意义的认知功能恢复

Targeting a brain hub involved in executive function, CNRT activates underperforming networks to reverse deficits and restore independence

CNRT 靶向参与执行功能的大脑枢纽，激活表现不佳的神经网络，以逆转缺陷并恢复独立生活能力。

Groundbreaking therapeutic approach has the potential to transform chronic cognitive impairment care from rehabilitation to restoration

开创性的治疗方法有望将慢性认知障碍的护理模式从康复转变为功能恢复

EDINA, Minn.

明尼苏达州伊代纳

,

，

Sept. 15, 2026

2026年9月15日

/PRNewswire/ --

/美通社/ --

ReEmerge, Inc.

ReEmerge 公司

(ReEmerge), a private MedTech company innovating a new way to address cognitive impairment, launched from stealth today following the close of an oversubscribed $37M Series A financing. The proceeds will support an upcoming clinical study that will evaluate ReEmerge's proprietary Cognitive Network Restoration Therapy (CNRT) in its first clinical indication, traumatic brain injury (TBI), while advancing technology development, expanding clinical and regulatory operations, and preparing the platform for future indications.

(ReEmerge) 是一家致力于以创新方式应对认知障碍的私营医疗科技公司，在完成超额认购的 3700 万美元 A 轮融资后，于今日正式从隐身模式亮相。所筹资金将支持即将开展的临床研究，评估 ReEmerge 专有技术“认知网络修复疗法”（CNRT）在首个临床适应症——创伤性脑损伤（TBI）中的疗效，同时推进技术开发，扩大临床和监管运营，并为该平台未来拓展其他适应症做好准备。

U.S. Venture Partners (USVP) and Santé co-led the round, with significant participation from Oxford Science Enterprises, 415 Capital, IAG Capital Partners, The Vertical Group, and Dendrion Ventures..

美国风投伙伴（USVP）和Santé共同领投了本轮融资，牛津科学企业、415 Capital、IAG Capital Partners、The Vertical Group以及Dendrion Ventures也大幅参与。

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ReEmerge is innovating a new way to approach chronic cognitive impairment with its Cognitive Network Restoration Therapy (CNRT).

ReEmerge 正通过其认知网络修复疗法（CNRT）创新性地开辟一种应对慢性认知障碍的新途径。

'ReEmerge's technology represents a fundamentally different approach to cognitive recovery with the potential to transform the recovery pathway,' commented Jonathan Root, MD, General Partner at USVP. 'The size of the opportunity and the profound unmet need make this an especially compelling market for innovation.

“ReEmerge的技术代表了一种从根本上不同的认知康复方法，有望改变康复路径。”美国风险合伙人公司（USVP）普通合伙人乔纳森·鲁特医学博士评论道。“巨大的市场机会和迫切的未满足需求，使这一领域成为极具吸引力的创新市场。”

We are excited about this technology and the new hope it aims to offer patients and their families.'.

我们对这项技术以及它旨在为患者及其家庭带来的新希望感到振奋。

'TBI does not discriminate. It can happen to anyone at any age, and its consequences can fundamentally alter a person's ability to live, work, and engage with the world around them,' said Auriel August, MD, Principal at Santé. 'CNRT could offer people living with TBI something they have too often been told not to expect, namely the possibility of meaningful cognitive recovery.'.

“创伤性脑损伤（TBI）不分人群。它可能发生在任何年龄段的任何人身上，其后果可能会从根本上改变一个人的生活、工作以及参与周围世界的能力，”Santé公司负责人Auriel August医学博士表示。“CNRT可以为创伤性脑损伤患者提供他们常常被告知不要期待的东西，即有意义的认知功能恢复的可能性。”

CNRT is a proprietary, first-of-its-kind approach that precisely targets neural networks in the central thalamus, a brain hub involved in attention, arousal, and executive function.  Rather than bypassing damaged pathways or asking patients to compensate for lost function, CNRT aims to augment the recovery journey by driving underactive but viable neural circuits.

CNRT 是一种专有的、首创的方法，能够精准靶向位于中央丘脑的神经网络；中央丘脑是大脑中参与注意力、觉醒和执行功能的关键枢纽。与绕过受损通路或要求患者代偿丧失的功能不同，CNRT 旨在通过激活活性不足但仍具可行性的神经回路，来促进康复进程。

By restoring function across existing but underperforming networks, CNRT aims to reverse cognitive deficits and allow recovery to extend further..

通过恢复现有但表现不佳的网络功能，CNRT旨在逆转认知缺陷，并使康复效果得以进一步延伸。

This technology grew out of decades of research by Nicholas Schiff, M.D. Professor of Neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine and colleagues at Stanford University and the University of Utah, which explored the possible restorative effect of brain electrical stimulation after TBI.

这项技术源于魏尔康奈尔医学院费伊家族脑与心智研究所神经科学教授尼古拉斯·希夫医学博士及其在斯坦福大学和犹他大学的同事们数十年的研究，该研究探讨了创伤性脑损伤后脑部电刺激可能具有的恢复作用。

A pilot study showed promising results, with patients regaining cognitive function. The Center for Technology Licensing at Weill Cornell worked closely with Dr. Schiff's team to protect the intellectual property, provide internal translational gap funding, and license the foundational intellectual property to ReEmerge to advance clinical and commercial development of CNRT..

一项初步研究显示出令人鼓舞的结果，患者恢复了认知功能。威尔康奈尔医学院技术许可中心与希夫博士的团队密切合作，保护知识产权，提供内部转化缺口资金，并将基础知识产权授权给ReEmerge公司，以推进CNRT的临床和商业化开发。

Building upon this groundbreaking clinical research, including a publication in

在此开创性临床研究的基础上，包括发表在

Nature Medicine

《自然医学》

, ReEmerge will conduct a prospective, single-arm, multicenter study (

，ReEmerge 将开展一项前瞻性、单臂、多中心研究（

NCT07730099

NCT07730099

) to evaluate this treatment, enrolling up to 40 patients with chronic moderate-to-severe TBI. Additionally, the study will explore potential effects on cognitive and functional outcomes.

）以评估该疗法，计划纳入最多40名患有慢性中重度创伤性脑损伤（TBI）的患者。此外，该研究还将探讨其对认知和功能结局的潜在影响。

'As a physician-scientist and co-founder, it has been very rewarding to see the arc of benchtop science moving forward and being translated into a meaningful clinical development pathway,' stated Dr. Schiff. 'I am excited for us to advance the testing of treatment for many patients, who have historically had limited therapeutic options, as we look to shift cognitive care from rehabilitation to restoration and ultimately, to redefine recovery.'.

“作为一名医师科学家兼联合创始人，看到基础科学研究不断向前推进，并转化为具有意义的临床开发路径，我感到非常有成就感，”Schiff博士表示。“随着我们致力于将认知护理从康复转向功能恢复，并最终重新定义‘康复’的内涵，我为能够为众多历史上治疗选择有限的患者推进治疗方案的测试而感到振奋。”

Each year, an estimated 27 million people worldwide experience a traumatic brain injury, and many are left with persistent cognitive impairment.

据估计，全球每年有2700万人遭受创伤性脑损伤，其中许多人会留下持续性的认知障碍。

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Current recovery pathways focus on rehabilitation, helping patients compensate for cognitive deficits through structured routines, adaptive strategies, and supportive therapies. While these interventions can improve function, the journey can be long, and recovery will often plateau, frequently leaving patients with lasting impairments that limit independence, quality of life, and personhood..

当前的康复途径主要侧重于康复治疗，通过结构化的日常安排、适应性策略和支持性疗法，帮助患者代偿认知缺陷。尽管这些干预措施可以改善功能，但康复过程往往漫长，且恢复常会进入平台期，导致患者遗留持久性的功能障碍，从而限制其独立性、生活质量和人格完整性。

'The strong support of our stellar investor syndicate validates our mission to evolve the recovery trajectory for patients living with impaired cognitive function,' said Todd Langevin, Chief Executive Officer of ReEmerge. 'We look forward to initiating our clinical study in TBI and building a robust body of evidence to support our differentiated approach to treating cognitive impairment.'.

ReEmerge 首席执行官 Todd Langevin 表示：“我们卓越的投资者财团给予的有力支持，印证了我们致力于改善认知功能受损患者康复轨迹的使命。我们期待启动针对创伤性脑损伤（TBI）的临床研究，并构建坚实的证据体系，以支持我们在治疗认知障碍方面的差异化方法。”

About ReEmerge, Inc.

关于 ReEmerge 公司

ReEmerge is innovating a new way to approach chronic cognitive impairment. Developed under an exclusive licensing agreement with Cornell University, the company's novel Cognitive Network Restoration Therapy (CNRT) precisely targets neural networks disrupted by brain injury that drive underactive but viable neural circuits.

ReEmerge 正在创新一种应对慢性认知障碍的新方法。在与康奈尔大学签订的独家许可协议下，该公司开发了 novel 认知网络修复疗法（CNRT），该疗法精准靶向因脑损伤而受损的神经网络，这些神经网络导致了功能低下但仍具活力的神经回路。

By restoring function across these existing but underperforming networks, CNRT aims to reverse cognitive deficits and restore agency and personhood. To learn more about how the company is developing therapeutic innovations that evolve cognitive care from rehabilitation to restoration, please visit .

通过恢复这些存在但功能不足的网络的功能，CNRT 旨在逆转认知缺陷，重建个体的自主能力与人格完整性。如需了解更多关于该公司如何开发将认知护理从康复提升至功能恢复的治疗创新的信息，请访问。

ReEmergeInc.com

ReEmergeInc.com

.

。

Media Contact

媒体联系人

Charlene Herndon

查琳·赫恩登

SPRIG Consulting

SPRIG 咨询公司

[email protected]

[email protected]

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Guan B, Anderson DB, Chen L

关斌，安德森·D·B，陈林

, et al.

等

Global, regional and national burden of traumatic brain injury and spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

1990–2019年全球、区域和国家层面的创伤性脑损伤和脊髓损伤负担：2019年全球疾病负担研究的系统分析

BMJ Open

BMJ Open

2023;13:e075049. doi: 10.1136/bmjopen-2023-075049

2023;13:e075049. doi: 10.1136/bmjopen-2023-075049

SOURCE ReEmerge, Inc.

来源：ReEmerge, Inc.

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