The final, formatted version of the article will be published soon.You have multiple emails registered with Frontiers:Please enter your email address:

这篇文章的最终格式化版本将很快发布。您在Frontiers注册了多封电子邮件：请输入您的电子邮件地址：

If you already have an account, please

如果您已经有账户，请

login

登录名

You don't have a Frontiers account ? You can

你没有Frontiers帐户？你可以

register hereBackground Serum albumin levels and cancer mortality are closely related, yet large-sample studies encompassing a broad spectrum of cancer types are lacking.This study encompassed patients diagnosed with cancer across the continuous 10 cycles of NHANES surveys from 1999 to 2018.

背景血清白蛋白水平与癌症死亡率密切相关，但缺乏涵盖广泛癌症类型的大样本研究。这项研究涵盖了1999年至2018年NHANES连续10个周期的癌症患者。

The study population was stratified into two groups based on median albumin levels (≤ 4.2g/dL and > 4.2 g/dL) or cancer aggressiveness (well-survived cancers and poorly-survived cancers). Survival rates were estimated using the Kaplan-Meier method. The Cox proportional hazards model was employed to evaluate the association between serum albumin levels and cancer mortality.

根据中位白蛋白水平（≤4.2g/dL和>4.2 g/dL）或癌症侵袭性（存活良好的癌症和存活不良的癌症），将研究人群分为两组。使用Kaplan-Meier方法估计存活率。Cox比例风险模型用于评估血清白蛋白水平与癌症死亡率之间的关联。

Restricted cubic spline (RCS) analysis was conducted to assess the nonlinear relationship between serum albumin levels and the risk of cancer mortality.Kaplan-Meier curves demonstrated that patients with albumin levels ≤ 4.2 g/dL exhibited lower survival rates compared to those with levels > 4.2 g/dL, irrespective of cancer aggressiveness.Following adjustment for confounders, decreased albumin levels were associated with an elevated risk of cancer mortality across all groups [all cancers, HR (95%CI) = 2.03(1.73, 2.37); well survived cancers, HR (95%CI) = 1.78(1.38, 2.32); and poorly survived cancers, HR (95%CI) = 1.99(1.64, 2.42)].

进行限制性三次样条（RCS）分析以评估血清白蛋白水平与癌症死亡风险之间的非线性关系。Kaplan-Meier曲线表明，白蛋白水平≤4.2 g/dL的患者与水平>4.2 g/dL的患者相比，存活率较低，与癌症侵袭性无关。调整混杂因素后，白蛋白水平降低与所有组癌症死亡风险升高相关[所有癌症，HR（95%CI）=2.03（1.73，2.37）；存活良好的癌症，HR（95%CI）=1.78（1.38，2.32）；存活不良的癌症，HR（95%CI）=1.99（1.64，2.42）]。

RCS analyses revealed a stable nonlinear negative association between albumin levels and cancer mortality in all groups, regardless of confounder adjustment.Conclusions Low serum albumin levels predict higher cancer mortality. Furthermore, a nonlinear negative association was observed between serum albumin levels and the risk of cancer mortality..

RCS分析显示，无论混杂因素调整如何，所有组中白蛋白水平与癌症死亡率之间均存在稳定的非线性负相关。结论低血清白蛋白水平预示着较高的癌症死亡率。此外，血清白蛋白水平与癌症死亡风险之间存在非线性负相关。。