ELK CITY, Idaho--(BUSINESS WIRE)--Therapeutic Solutions International, Inc. (TSOI), announced today data demonstrating that JadiCell administration is capable of increasing gene therapy mediated production of therapeutic cells in vivo.

爱达荷州麋鹿城——（商业新闻短讯）——治疗解决方案国际公司（TSOI）今天公布的数据表明，JadiCell管理能够增加体内基因治疗介导的治疗细胞的产生。

In a series of experiments the Company showed that animals made deficient in a hormone producing cells can be treated with great efficacy by combining differentiation promoting gene therapy with JadiCell administration. The observation was made in several models of gene therapy induced cellular differentiation/transdifferentiation and was reproducible with other cells of the mesenchymal stem cell family, although the JadiCell proved the most efficacious..

在一系列实验中，该公司表明，通过将促进分化的基因疗法与JadiCell给药相结合，可以有效地治疗缺乏激素产生细胞的动物。该观察是在几种基因治疗诱导的细胞分化/转分化模型中进行的，并且可以与间充质干细胞家族的其他细胞重复，尽管JadiCell被证明是最有效的。。

“We are living in a historic time in which gene therapy has been successfully used to change cells within the body of a patient. For example, insertion of one type of gene can generate blood vessel cells1, another gene can generate cardiac cells2, yet others can generate muscle cells3,” said Dr. Thomas Ichim, Board Member, and co-inventor of the technology.

“我们生活在一个历史性的时代，基因疗法已成功用于改变患者体内的细胞。例如，插入一种基因可以产生血管细胞1，另一种基因可以产生心肌细胞2，而其他基因可以产生肌肉细胞3，”该技术的共同发明人、董事会成员托马斯·伊希姆博士说。

“Unfortunately, the biggest hurdle to clinical translation of such approaches is low efficacy. We are confident that the finds disclosed today will help accelerate the widespread clinical implementation of gene therapy mediated creation of therapeutic cells in the body.”.

“不幸的是，这些方法临床转化的最大障碍是低效。我们相信今天公布的发现将有助于加速基因治疗介导的体内治疗细胞产生的广泛临床实施。”。

“Therapeutic Solutions International is an ‘Innovation Factory’ that leverages its core expertise in regenerative medicine and immunology to hyper accelerate advancement of new therapeutic approaches from the lab to the patient,” said Timothy Dixon, President, and CEO of the Company and co-inventor.

该公司总裁兼首席执行官兼共同发明人蒂莫西·迪克森（TimothyDixon）表示：“治疗解决方案国际是一家‘创新工厂’，利用其在再生医学和免疫学方面的核心专业知识，大大加速了从实验室到患者的新治疗方法的发展。”。

“We are currently seeking collaborators/licensees to implement this new technology of regenerative gene therapy.”.

“我们目前正在寻求合作者/被许可人来实施这种再生基因治疗新技术。”。

About Therapeutic Solutions International, Inc.

关于治疗解决方案国际公司。

Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com.

治疗解决方案国际专注于治疗几种特定疾病的免疫调节。该公司的公司网站是www.theraperosolutionsint.com。

1 McCoy et al. A miRNA cassette reprograms smooth muscle cells into endothelial cells. FASEB J. 2022 Apr;36(4):e22239.

1 McCoy等人。miRNA盒将平滑肌细胞重编程为内皮细胞。FASEB J.2022年4月；36（4）：e22239。

2 Bektik et al. Production of Cardiomyocyte-Like Cells by Fibroblast Reprogramming with Defined Factors. Methods Mol Biol . 2021:2239:33-46.

2 Bektik等人。通过具有确定因子的成纤维细胞重编程产生心肌细胞样细胞。方法Mol Biol。2021:2239:33-46。

3 Almeida et al. Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders. J Vis Exp. 2021 Apr 3:(170).

3 Almeida等人。将人成纤维细胞直接重编程为成肌细胞，以研究神经肌肉疾病的治疗方法。J Vis Exp.2021年4月3日：（170）。