Grant awards to fund novel clinical projects and scientific tools aimed at improving quality of life for individuals impacted by spinal cord injury

授予奖项，以资助旨在改善脊髓损伤患者生活质量的新型临床项目和科学工具

SHORT HILLS, N.J., March 6, 2024 /PRNewswire/ -- The Christopher & Dana Reeve Foundation, a leading nonprofit organization dedicated to curing spinal cord injury by funding innovative research and improving the quality of life for individuals and families impacted by paralysis, announced today three new spinal cord injury (SCI) research grants totaling $3.1 million.

新泽西州肖特希尔斯，2024年3月6日/PRNewswire/--克里斯托弗和达纳·里夫基金会（Christopher＆DanaReeve Foundation）是一家领先的非营利组织，致力于通过资助创新研究和改善受瘫痪影响的个人和家庭的生活质量来治疗脊髓损伤，今天宣布了三项新的脊髓损伤（SCI）研究拨款，总计310万美元。

The grants support clinical trials and research tools aimed at accelerating the therapeutic development of SCI treatments..

这些赠款支持旨在加速SCI治疗的治疗发展的临床试验和研究工具。。

Two grants have been awarded to .NeuroRestore, a research, innovation and treatment center that develops and applies bioengineering strategies involving neurosurgical interventions to restore neurological functions. PsychoGenics, a CNS-focused contract research organization that designs and executes preclinical drug discovery and early development programs, received the third grant..

两项赠款已授予。NeuroRestore是一家研究、创新和治疗中心，开发和应用涉及神经外科干预的生物工程策略来恢复神经功能。PsychoGenics是一家专注于中枢神经系统的合同研究组织，负责设计和执行临床前药物发现和早期开发计划，获得了第三笔赠款。。

Together, the grants will fund projects designed to help catalyze and energize the field of SCI science by channeling resources for a robust clinical pipeline to rapidly increase the number of potential treatments, as well as drive progress and investment in spinal cord injury research by addressing the barriers that limit ambitious engagement..

这些赠款将共同资助旨在帮助催化和振兴SCI科学领域的项目，通过为强大的临床管道输送资源，以迅速增加潜在治疗的数量，并通过解决限制雄心勃勃的参与的障碍来推动脊髓损伤研究的进展和投资。。

The projects include clinical trials focused on: bladder dysfunction – a major quality-of-life issue for the SCI community; and a trial to advance novel brain-spine interface (BSI) technology, which has been shown to enable thought to control movement. Finally, a preclinical study will focus on innovative techniques and technologies to provide standardized lab research resources that do not currently exist.

这些项目包括临床试验，重点是：膀胱功能障碍-SCI社区的主要生活质量问题；以及一项旨在推进新型脑-脊柱界面（BSI）技术的试验，该技术已被证明能够使思维控制运动。最后，临床前研究将侧重于创新技术和技术，以提供目前尚不存在的标准化实验室研究资源。

Specifically:.

具体来说：。

Brain-Spine Interface to Reverse Upper Limb Paralysis: .NeuroRestore will also receive $1.1 million over two years to support its Brain-Spinal Interface (BSI) technology to determine if thoughts, via cortical brain implants, can control not just lower extremity movement (which has been demonstrated in prior research), but also arm and hand function for those with cervical injuries.

脑脊液界面逆转上肢瘫痪：。NeuroRestore还将在两年内获得110万美元，用于支持其脑脊髓接口（BSI）技术，以确定通过皮质脑植入物的思维是否不仅可以控制下肢运动（先前的研究已经证明），还可以控制颈椎损伤患者的手臂和手部功能。

This technology is being developed by ONWARD® Medical, a medical technology company creating therapies to restore movement, function, and independence in people with SCI and movement disabilities. It is the only company currently advancing both brain-computer interface (BCI) and spinal cord stimulation technology together – a 'digital bridge' connecting brain signals with movement.

这项技术由Forward®Medical开发，这是一家医疗技术公司，旨在为SCI和运动障碍患者提供恢复运动，功能和独立性的疗法。它是目前唯一一家同时推进脑机接口（BCI）和脊髓刺激技术的公司，这是一座连接大脑信号和运动的“数字桥梁”。

In late February, ONWARD Medical was awarded its 10th Breakthrough Device Designation (BDD) by the US Food and Drug Administration (FDA) for its ARC-BCI™ System, which uses brain-BCI technology in conjunction with the company's ARC-IM® Therapy to restore thought-driven lower limb mobility after spinal cord injury (SCI)..

2月下旬，Forward Medical因其ARC-BCI™系统获得美国食品和药物管理局（FDA）授予的第十个突破性设备称号（BDD），该系统将脑BCI技术与公司的ARC-IM®疗法结合使用，以恢复脊髓损伤（SCI）后思维驱动的下肢活动能力。。

Neuroprosthetic System to Manager Lower Urinary Tract Dysfunction After Spinal Cord Injury: With a $1.5 million grant, .NeuroRestore will apply epidural stimulation implants to participants with chronic incomplete spinal cord injuries to examine if the technology can be used to assist in the functionality and control of the bladder.

用于管理脊髓损伤后下尿路功能障碍的神经假体系统：获得150万美元的赠款。NeuroRestore将向患有慢性不完全性脊髓损伤的参与者应用硬膜外刺激植入物，以检查该技术是否可用于辅助膀胱的功能和控制。

This proof-of-concept, safety, and feasibility study over two years will determine if epidural stimulation, which has seen success in movement and blood pressure, can be used for voiding and storage of the bladder.This early-stage study will utilize ONWARD Medical's targeted ARC Therapy stimulation, which the company is actively developing with .NeuroRestore..

这项为期两年的概念验证，安全性和可行性研究将确定硬膜外刺激是否可以用于排尿和储存膀胱，硬膜外刺激在运动和血压方面取得了成功。这项早期研究将利用Forward Medical的靶向ARC治疗刺激，该公司正在积极开发。神经恢复。。

Standardized Testing Research InVivo Endeavor (STRIVE): A preclinical grant for $522,000 is awarded to PsychoGenics to develop an in-house standardized model for testing potential therapeutics. This project will help accelerate therapeutic development by providing a validated tool to the SCI research community..

标准化测试研究InVivo Endeavor（STRIVE）：一笔522000美元的临床前拨款被授予心理遗传学，以开发一个内部标准化模型来测试潜在的治疗方法。该项目将通过为SCI研究界提供经过验证的工具来帮助加速治疗发展。。

The Reeve Foundation is dedicated to developing real-world treatments for people living with spinal cord injury (SCI) and paralysis. Decade by decade, the Reeve Foundation has worked to change what was deemed possible, collaborating with equally determined scientists and labs to map a path toward progress and build a vibrant research field that delivers real improvements for people living with paralysis.

里夫基金会致力于为脊髓损伤（SCI）和瘫痪患者开发现实世界的治疗方法。十年又十年，里夫基金会一直在努力改变人们认为可能的事情，与同样坚定的科学家和实验室合作，绘制一条通往进步的道路，并建立一个充满活力的研究领域，为瘫痪患者提供真正的改善。

Today, as 21st-century technology and cumulative scientific gains converge, we are on the cusp of a new era in spinal cord injury research..

今天，随着21世纪技术和累积科学成果的融合，我们正处于脊髓损伤研究新时代的尖端。。

'These grants represent a fresh approach to spurring the SCI scientific arena forward through our support of high-risk-high-reward endeavors that address unmet needs of individuals living with spinal cord injury,' said Marco Baptista, Ph.D., Chief Scientific Officer of the Reeve Foundation. 'It is our goal to facilitate rapid scientific advancement, and these grants are an important step in ensuring that the most promising science of the day is primed for accelerated success.'.

里夫基金会首席科学官马可·巴普蒂斯塔（MarcoBaptista）博士说：“这些赠款代表了一种新的方法，通过我们支持高风险高回报的努力来推动SCI科学领域向前发展，这些努力旨在解决脊髓损伤患者未得到满足的需求。”我们的目标是促进科学的快速发展，这些赠款是确保当今最有前途的科学为加速成功做好准备的重要一步。”。

About the Reeve Foundation

关于里夫基金会

The Christopher & Dana Reeve Foundation is dedicated to curing spinal cord injury by funding innovative research and improving the quality of life for individuals and families impacted by paralysis. Additionally, through a cooperative agreement with the Administration for Community Living, the Reeve Foundation's National Paralysis Resource Center (NPRC) promotes the health, well-being, and independence of people living with paralysis, providing comprehensive information, resources, and referral services assisting over 125,000 individuals and families since its launch in 2002.

克里斯托弗和达纳·里夫基金会致力于通过资助创新研究和改善受瘫痪影响的个人和家庭的生活质量来治疗脊髓损伤。此外，通过与社区生活管理局的合作协议，里夫基金会的国家瘫痪资源中心（NPRC）促进了瘫痪患者的健康，福祉和独立性，提供了全面的信息，资源和转诊服务，自2002年成立以来，为超过125000个人和家庭提供了帮助。

The Reeve Foundation is committed to elevating our community's voices and needs to achieve greater representation and independence. We meet all 20 of the Better Business Bureau's standards for charity accountability and hold the BBB's Charity Seal. For more information, please visit ChristopherReeve.org or call 800-225-0292..

里夫基金会致力于提高我们社区的声音，并需要实现更大的代表性和独立性。我们符合更好的商业局（Better Business Bureau）所有20项慈善问责标准，并持有BBB的慈善印章。欲了解更多信息，请访问ChristopherReeve.org或致电800-225-0292。。

SOURCE Christopher & Dana Reeve Foundation

来源：克里斯托弗和达纳·里夫基金会