PORTLAND, Ore.--(BUSINESS WIRE)--At the 20th US Human Proteome Organization Congress 2024, Bruker Corporation (Nasdaq: BRKR) announced progress in immunopeptidomics, glycoproteomics and other CCS-enabled 4D-proteomics workflows. The rapid advances in deep, at-scale proteomics, glycomics and peptidomics research solutions complement other performance-leading life-science tools for the post-genomic era by Bruker.

俄勒冈州波特兰市——（商业新闻短讯）——在2024年第20届美国人类蛋白质组组织大会上，布鲁克公司（Nasdaq:BRKR）宣布了免疫肽组学、糖蛋白组学和其他支持CCS的4D蛋白质组学工作流程的进展。Bruker在深度，大规模蛋白质组学，糖组学和肽组学研究解决方案方面的快速进步补充了后基因组时代其他性能领先的生命科学工具。

Together they enable post-genomic molecular and cell biology research, with key insights into disease biology and biomarkers for next-gen molecular diagnostics and drug discovery..

它们共同实现了后基因组分子和细胞生物学研究，为下一代分子诊断和药物发现提供了对疾病生物学和生物标志物的关键见解。。

The advances featured at US HUPO include improved machine-learning de novo sequencing (Novor V2.0), a novel high-performance monitoring digital-twin software (TwinScape), the new glyco-PASEF method for high-sensitivity glycopeptide analysis, and access to Spectronaut 18 for users of Bruker ProteoScape, a GPU-powered software for real-time 4D proteomics, now with access to library-free searches by Biognosys directDIA®..

美国HUPO的进步包括改进的机器学习从头测序（Novor V2.0），一种新型的高性能监测数字双胞胎软件（TwinScape），用于高灵敏度糖肽分析的新glyco-PASEF方法，以及Bruker ProteoScape（一种GPU驱动的实时4D蛋白质组学软件）用户访问Spectronaut 18，现在可以通过Biognosys directDIA®访问图书馆免费搜索。。

A. Advancing Cancer Immunotherapy Research

A、 推进癌症免疫治疗研究

Bruker enhances its timsTOF HT and timsTOF Ultra systems with the new software Novor v2.0 for de novo immunopeptidomic profiling. Novor v2.0, developed in collaboration with Rapid Novor Inc., was trained on >1,400,000 spectra mapping to >150,000 HLA peptides for research on small amounts of patient material derived from fine needle biopsies..

布鲁克使用新软件Novor v2.0增强了其timsTOF HT和timsTOF Ultra系统，用于从头进行免疫肽组分析。与Rapid Novor Inc.合作开发的Novor v2.0接受了超过1400000个光谱映射到>150000个HLA肽的培训，用于研究来自细针活检的少量患者材料。。

Dr. Juliane Walz, Professor of Peptide-based Immunotherapy and Medical Director for Translational Immunology at Universitätsklinikum Tübingen in Germany commented: “Our research focuses on the field of immunology and the development of novel peptide-based immunotherapy concepts for tumor and infectious diseases.

JulianeWalz博士是德国蒂宾根大学肽基免疫疗法教授兼转化免疫学医学主任，他评论道：“我们的研究重点是免疫学领域以及针对肿瘤和传染病的新型肽基免疫疗法概念的开发。

Bruker’s trapped ion mobility separation combination with time-of-flight mass spectrometry enables immunopeptidomics with high speed and sensitive detection of HLA-presented peptides. Applying this technology, we have expanded the benign reference immunopeptidome databases with >150,000 HLA peptides.

布鲁克的捕获离子迁移率分离与飞行时间质谱相结合，使免疫肽组学能够快速灵敏地检测HLA呈递的肽。应用这项技术，我们扩展了具有>150000个HLA肽的良性参考免疫肽组数据库。

This allows us to confidently define tumor-associated antigens to fast-track immunotherapy development.”.

这使我们能够自信地定义肿瘤相关抗原，以快速追踪免疫疗法的发展。”。

B. Peak timsTOF Performance using TwinScape

B、 使用TwinScape的峰值timsTOF性能

TwinScape is a new digital-twin performance monitoring and quality control engine, leveraging iRT peptide standards to support sustained peak performance in sample prep and LC-MS. For synergistic multi-omics studies in the post-genomic era, a combination of depth of coverage, robustness, and scalable quantitation is required.

TwinScape是一种新的数字双胞胎性能监测和质量控制引擎，利用iRT肽标准来支持样品制备和LC-MS的持续峰值性能。对于后基因组时代的协同多组学研究，需要结合覆盖深度，稳健性和可扩展的定量。

TwinScape enables larger controlled studies and valid cross-lab comparability..

TwinScape能够进行更大规模的对照研究和有效的跨实验室可比性。。

Dr. Anne-Claude Gingras, VP of Research at Sinai Health, Director at Lunenfeld-Tanenbaum Research Institute, and Professor in Molecular Genetics in Toronto, Canada said: “We support a variety of projects in our proteomics facility. It is critical that our instruments are at peak performance and that we always have a pulse on them.

西奈健康研究副总裁、Lunenfeld Tanenbaum研究所所长、加拿大多伦多分子遗传学教授Anne Claude Gingras博士说：“我们支持我们蛋白质组学设施中的各种项目。至关重要的是，我们的仪器处于最佳性能，并且我们始终对它们保持关注。

The combination of Bruker ProteoScape, TwinScape and the Biognosys iRT kit have become integral for monitoring our instruments to ensure everything is operating up to highest standards. TwinScape is great for an over-time view of QC and system performance. It has been especially useful in pinpointing if there ever is a sample, LC or MS problem.”.

Bruker ProteoScape，TwinScape和Biognosys iRT试剂盒的组合已成为监测我们仪器的不可或缺的组成部分，以确保一切都符合最高标准。TwinScape非常适合随时间查看QC和系统性能。它在确定是否存在样品，LC或MS问题方面特别有用。“。

C. New glyco-PASEF for Ultra-High Sensitivity 4D-Glycopeptide Analysis

C、 用于超高灵敏度4D糖肽分析的新型glyco-PASEF

Bruker presents the novel timsTOF glyco-PASEF method with polygon filtering developed with the Heck Group at Utrecht University, the GlycoScape software developed collaboratively with the Van Gool Group at Radboud University, and MSFragger-Glyco software developed by the Nesvizhskii Group at the University of Michigan..

布鲁克提出了一种新颖的timsTOF glyco-PASEF方法，该方法具有与乌得勒支大学Heck小组开发的多边形过滤，与拉德布德大学Van Gool小组合作开发的GlycoScape软件，以及由密歇根大学Nesvizhskii小组开发的MSFragger glyco软件。。

Dr. Albert Heck, Professor of Chemistry and Pharmaceutical Sciences at Utrecht University and Scientific Director of the Netherlands Proteomics Center, noted: “I am pleased with our pioneering work in leveraging the unique strengths of the timsTOF platform for glycoproteomics, now translated to the glyco-PASEF method for research in glycobiology.”.

乌得勒支大学化学与药物科学教授兼荷兰蛋白质组学中心科学主任阿尔伯特·赫克博士指出：“我很高兴我们在利用timsTOF糖蛋白组学平台的独特优势方面所做的开创性工作，该平台现已转化为用于糖生物学研究的glyco-PASEF方法。”。

Bruker is now offering GlycoScape™ real-time glycoproteomic software, developed with Alain van Gool’s team at Radboud University, for early access beta-testing.

布鲁克目前正在提供GlycoScape™实时糖蛋白组学软件，该软件是与拉德布德大学的阿兰·范古尔团队共同开发的，用于早期获取β测试。

Bruker also announces that the MSFragger-Glyco software now supports timsTOF data. Dr. Alexey Nesvizhskii, Professor of Computational Medicine, Bioinformatics and Pathology at University of Michigan, and creator of MSFragger, stated: “My team is gratified by the popularity of MSFragger for ultrafast searches, including the identification of post-translationally modified peptides.

布鲁克还宣布，MSFragger Glyco软件现在支持timsTOF数据。密歇根大学计算医学、生物信息学和病理学教授、MSFragger创始人Alexey Nesvizhskii博士表示：“我的团队对MSFragger在超快搜索中的普及感到满意，包括鉴定翻译后修饰的肽。

Our software suite supports the analysis of PASEF data, and we are delighted that Bruker now offers it with timsTOF instruments. This recognition acknowledges the broad applicability of our tools to timsTOF-generated proteomics data.”.

我们的软件套件支持PASEF数据的分析，我们很高兴布鲁克现在为其提供了timsTOF instruments。这一认识承认了我们的工具对timsTOF生成的蛋白质组学数据的广泛适用性。”。

D. Software Advances for dia-PASEF®

D、 dia PASEF®的软件改进

The newest release of Bruker ProteoScape makes a Spectronaut 18 module available for dia-PASEF analysis, enabling real-time results using GPU computing, including directDIA for library-free searches. Bruker ProteoScape now also upgrades TIMS DIA-NN software to version 3.0 with improved quantitation accuracy..

Bruker ProteoScape的最新版本使Spectronaut 18模块可用于dia PASEF分析，从而使用GPU计算实现实时结果，包括directDIA用于无库搜索。布鲁克ProteoScape现在还将TIMS DIA-NN软件升级到3.0版，提高了定量精度。。

About Bruker Corporation – the Emerging Leader of the Post-Genomic Era

关于布鲁克公司——后基因组时代的新兴领导者

Bruker (Nasdaq: BRKR) is enabling scientists to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels.

布鲁克（纳斯达克股票代码：BRKR）正在帮助科学家取得突破性的后基因组发现，并开发新的应用程序，以改善人类生活质量。布鲁克的高性能科学仪器和高价值的分析和诊断解决方案使科学家能够在分子，细胞和微观水平上探索生命和材料。

In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and pharma applications, in microscopy and nanoanalysis, as well as in industrial applications. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics.

布鲁克与我们的客户密切合作，在后基因组生命科学分子和细胞生物学研究、应用和制药应用、显微镜和纳米分析以及工业应用中实现创新、提高生产力和客户成功。布鲁克在临床前成像、临床表型研究、蛋白质组学和多组学、空间和单细胞生物学、功能结构和冷凝生物学以及临床微生物学和分子诊断领域提供差异化的高价值生命科学和诊断系统和解决方案。

For more information, please visit www.bruker.com..

欲了解更多信息，请访问www.bruker.com。。