Freezing treatment dissipates tumors in breast cancer patients who are not eligible for surgery

冷冻治疗可以消除不符合手术条件的乳腺癌患者的肿瘤

FAIRFAX, Va., March 23, 2024 /PRNewswire/ -- A minimally invasive technique that uses ice to freeze and destroy small, cancerous tumors has now been proven effective for breast cancer patients with large tumors, providing a new treatment path for those who are not candidates for surgery, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City..

弗吉尼亚州费尔法克斯。，2024年3月23日，据盐湖城介入放射学学会年度科学会议上发表的一项新研究显示，一种使用冰冷冻和破坏小的癌性肿瘤的微创技术现已被证明对患有大肿瘤的乳腺癌患者有效，为那些不适合手术的患者提供了一条新的治疗途径。。

'For patients who have larger tumors but can't undergo surgery, this approach could be more effective than the current standard of care for patients who are not surgical candidates,' said Yolanda Bryce, M.D., an interventional radiologist at Memorial Sloan Kettering Cancer Center. 'When treated with only radiation and hormonal therapy, tumors will eventually return.

纪念斯隆凯特琳癌症中心的介入放射科医生约兰达·布莱斯医学博士说：“对于肿瘤较大但无法接受手术的患者，这种方法可能比目前对非手术患者的标准治疗更有效。”当只接受放射和激素治疗时，肿瘤最终会复发。

So, the fact that we saw only a 10% recurrence rate in our study is incredibly promising.'.

因此，在我们的研究中，我们只看到了10%的复发率，这一事实令人难以置信地有希望。”。

Cryoablation is a minimally invasive treatment that uses imaging guidance such as ultrasound or a computed tomography (CT) scan to locate tumors. An interventional radiologist will then insert small, needle-like probes into the breast to create an ice ball that surrounds the tumor, killing the cancer cells.

冷冻消融是一种微创治疗方法，使用超声或计算机断层扫描（CT）扫描等成像指导来定位肿瘤。然后，介入放射科医生将针状探针插入乳房，形成一个围绕肿瘤的冰球，杀死癌细胞。

When combined with hormonal therapy and radiation, patients can have nearly 100% of their tumors destroyed. If the tumors do grow, patients can be treated with cryoablation multiple times to control growth. The treatment has been successfully used to treat tumors smaller than 1.5 cm, but its effectiveness on larger tumors was not extensively demonstrated until now..

当与激素治疗和放射治疗相结合时，患者可以100%地摧毁其肿瘤。如果肿瘤确实生长，患者可以多次接受冷冻消融治疗以控制生长。该疗法已成功用于治疗小于1.5 cm的肿瘤，但迄今为止尚未广泛证明其对较大肿瘤的有效性。。

This retrospective study assessed outcomes for 60 patients who underwent cryoablation because they were not candidates for surgery or refused surgery after consultation with a breast surgeon due to age, cardiac issues, hypertension, or currently undergoing chemotherapy for another cancer. Their tumor sizes ranged from 0.3 – 9 cm with an average size of 2.5cm.

这项回顾性研究评估了60名接受冷冻消融的患者的结果，因为他们由于年龄，心脏问题，高血压或目前正在接受另一种癌症的化疗而不适合手术或在咨询乳腺外科医生后拒绝手术。他们的肿瘤大小范围为0.3-9厘米，平均大小为2.5厘米。

Patients with tumors larger than 1.4 cm were treated with multiple probes (one probe placement for each centimeter of disease). In a follow-up after 16 months, the recurrence rate was just 10%..

肿瘤大于1.4 cm的患者接受多个探针治疗（每厘米疾病放置一个探针）。在16个月后的随访中，复发率仅为10%。。

'Surgery is still the best option for tumor removal, but there are thousands of women who, for various reasons, cannot have surgery,' said Bryce. 'We are optimistic that this can give more women hope on their treatment journeys.'

布莱斯说：“手术仍然是切除肿瘤的最佳选择，但由于各种原因，成千上万的女性无法接受手术。”我们乐观地认为，这可以为更多女性的治疗之旅带来希望。”

The procedures were performed with local anesthesia or minimal sedation, depending on the eligibility and preference of the patient. The freeze-thaw cycle started with 5-10 minutes of freezing, followed by 5-8 minutes of passive thaw, and then 5-10 minutes freezing at 100% intensity. Patients were able to go home on the same day, following the treatment..

根据患者的资格和偏好，手术采用局部麻醉或最小程度的镇静。冻融循环从5-10分钟的冷冻开始，然后是5-8分钟的被动解冻，然后以100%的强度冷冻5-10分钟。治疗后，患者能够在同一天回家。。

The researchers will continue to follow the patient cohort to collect data on long-term effectiveness and to better understand the impact that adjuvant (e.g. hormone therapy and radiation) therapies combined with cryoablation can have on this patient population.

研究人员将继续跟踪患者队列，以收集长期有效性的数据，并更好地了解辅助治疗（例如激素治疗和放射治疗）联合冷冻消融对该患者群体的影响。

Abstract #2: Breast cancer recurrence after cryoablation. J. Jean, Y. Bryce. Annual Scientific Meeting, March 23-28, 2024. This abstract can be found at sirmeeting.org.

摘要#2：冷冻消融后乳腺癌复发。J、 Jean，Y.Bryce。年度科学会议，2024年3月23日至28日。这个摘要可以在sirmeeting.org上找到。

About the Society of Interventional RadiologyThe Society of Interventional Radiology is a nonprofit, professional medical society representing more than 8,000 practicing interventional radiology physicians, trainees, students, scientists and clinical associates, dedicated to improving patient care through the limitless potential of image-guided therapies.

关于介入放射学学会介入放射学学会是一个非营利的专业医学学会，代表8000多名执业介入放射学医师，实习生，学生，科学家和临床助理，致力于通过图像引导疗法的无限潜力来改善患者护理。

SIR's members work in a variety of settings and at different professional levels—from medical students and residents to university faculty and private practice physicians. Visit sirweb.org..

SIR的成员在各种环境和不同的专业水平上工作，从医学生和住院医生到大学教师和私人执业医生。访问sirweb.org。。

The Society of Interventional Radiology is holding its Annual Scientific Meeting in Salt Lake City March 23 - 27, 2024. Visit sirmeeting.org.

介入放射学学会将于2024年3月23日至27日在盐湖城举行年度科学会议。访问sirmeeting.org。

SOURCE Society of Interventional Radiology

介入放射学源学会