REDMOND, Wash., March 28, 2024 /PRNewswire/ -- More than 155 International researchers and data scientists met this week in the Pacific Northwest to share with each other the newest insights into the causes of Sudden Infant Death Syndrome (SIDS). The event was sponsored by The Center for Integrative Brain Research at Seattle Children's and Microsoft AI for Good Lab.

华盛顿州雷德蒙德，2024年3月28日，超过155名国际研究人员和数据科学家本周在太平洋西北部会面，分享关于婴儿猝死综合征（SIDS）病因的最新见解。该活动由西雅图儿童综合大脑研究中心和微软AI for Good Lab赞助。

Among the many topics attendees discussed was groundbreaking new research that suggests genetic testing at birth may hold the promise of detecting SIDS risk — and potentially other causes of sudden death later in life..

与会者讨论的众多主题中，有一项开创性的新研究表明，出生时的基因检测可能有望检测出小岛屿发展中国家的风险，以及可能导致晚年猝死的其他原因。。

SIDS is the leading cause of death of infants one month to one year old in the US and other developed countries. The new findings, resulting from a partnership between the Center for Integrative Brain Research at Seattle Children's and data scientists at Microsoft, come from the first-ever whole genome sequencing of 145 infants who succumbed to SIDS.

小岛屿发展中国家是美国和其他发达国家一个月至一岁婴儿死亡的主要原因。西雅图儿童综合大脑研究中心与微软数据科学家合作，首次对145名死于小岛屿发展中国家的婴儿进行了全基因组测序，得出了这一新发现。

The Aaron Matthew SIDS Research Foundation funds the database, which is maintained and managed at Seattle Children's Research Institute..

Aaron Matthew SIDS研究基金会为该数据库提供资金，该数据库由西雅图儿童研究所维护和管理。。

In a study, soon to be published in the American Journal of Medical Genetics, researchers identify novel genes associated with Sudden Unexplained Infant Deaths (SUID), which includes SIDS. Some of these genes are important for detecting and responding to hypoxia — low levels of oxygen in body tissues.

在一项即将发表在《美国医学遗传学杂志》上的研究中，研究人员发现了与不明原因婴儿猝死（SUID）相关的新基因，其中包括小岛屿发展中国家。其中一些基因对于检测和应对缺氧（身体组织中的低氧水平）很重要。

Children with these vulnerabilities could increase their susceptibility to death caused from sleeping face down..

有这些脆弱性的儿童可能会增加他们因面朝下睡觉而死亡的可能性。。

For decades, medical professionals have found a correlation between the sleeping position of infants and SIDS. This research suggests why that risk exists for certain infants. The study also identified genes associated with Sudden Cardiac Death, which could also explain why some children are particularly vulnerable to succumb to SIDS.

几十年来，医学专业人员发现婴儿的睡眠姿势与小岛屿发展中国家之间存在相关性。这项研究表明，为什么某些婴儿存在这种风险。该研究还确定了与心源性猝死相关的基因，这也可以解释为什么一些儿童特别容易死于小岛屿发展中国家。

However, because not every child with this vulnerability will succumb to SIDS, those who survive may be vulnerable to Sudden Cardiac Death later in life. Sudden Cardiac Death is responsible for 360,000 fatalities annually in the United States..

然而，由于并非每个有这种脆弱性的儿童都会死于小岛屿发展中国家，因此那些幸存下来的儿童可能在以后的生活中容易发生心源性猝死。在美国，每年有36万人死于心脏猝死。。

'Scientific research sometimes leads to surprises,' said Jan-Marino Ramirez, PhD, Director of the Center for Integrative Brain Research at Seattle Children's. 'One surprise in our research leads to an exciting question: what if a genetic test at birth could not only predict the risk of SIDS, but also terminal cardiac problems well into adulthood? Preventative treatments exist for these dangerous conditions, and early detection could save lives.'.

西雅图儿童综合大脑研究中心主任扬·马里诺·拉米雷斯（JanMarinoRamirez）博士说：“科学研究有时会带来惊喜。我们研究中的一个惊喜引发了一个令人兴奋的问题：如果出生时的基因检测不仅可以预测小岛屿发展中国家的风险，而且可以预测成年后的终末期心脏问题，该怎么办？”？针对这些危险情况存在预防性治疗，早期发现可以挽救生命。”。

John Kahan, the former Microsoft Vice President and Chief Data Analytics Officer who co-founded The Aaron Matthew SIDS Research Foundation with his wife Heather Kahan, organized the first SIDS Summit while he was working at Microsoft.

前微软副总裁兼首席数据分析官约翰·卡恩（JohnKahan）与妻子希瑟·卡恩（HeatherKahan）共同创立了亚伦·马修·西兹研究基金会（AaronMatthewSids Research Foundation），他在微软工作期间组织了第一届SIDS峰会。

'Thanks to this collaboration between world-class researchers and data scientists armed with cutting edge AI, we can now use genetic data to predict children at high risk of SIDS, which claims approximately 3,200 children a year,' Kahan said. 'We are getting far closer to enabling medical professionals to bring preventative treatments to children who exhibit these risks, and potentially to far more people — those susceptible to Sudden Cardiac Death later in life.' .

卡恩说：“由于世界一流的研究人员和拥有尖端人工智能的数据科学家之间的合作，我们现在可以使用遗传数据来预测小岛屿发展中国家高危儿童，每年约有3200名儿童死亡。”。“我们越来越接近于让医疗专业人员为表现出这些风险的儿童提供预防性治疗，并可能为更多的人提供预防性治疗，这些人在以后的生活中容易发生心源性猝死。”。

Juan M. Lavista Ferres PhD, MS, Microsoft Chief Data Scientist and the Director of the AI For Good Lab at Microsoft, is among those who hosted the Summit this week. Dr. Lavista was the lead researcher who used big data to estimate that 22% of Sudden or Unexplained Infant Deaths in the United States can be directly attributed to maternal smoking during pregnancy, which led to the assertion that SIDS rates can be reduced through education programs about the risks of smoking during pregnancy.

胡安·M·拉维斯塔·费雷斯（JuanM.LavistaFerres）博士、微软首席数据科学家兼微软人工智能良好实验室主任，是本周峰会的东道主之一。Lavista博士是首席研究人员，他使用大数据估计，美国22%的突然或无法解释的婴儿死亡可直接归因于孕期母亲吸烟，这导致了一种说法，即可以通过关于怀孕期间吸烟风险的教育计划来降低小岛屿发展中国家的发病率。

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'The learning  from this collaboration with SIDS researchers is proving, once again, the power AI has to scale human expertise,' Dr. Lavista said. 'It's a privilege for my team to put AI in the hands of some of the leading medical researchers in the world, and to see the number of potentially life-saving outcomes that flow from their work, partly through their access to AI.'.

拉维斯塔博士说：“从与小岛屿发展中国家研究人员的合作中学到的经验再次证明，人工智能有能力扩展人类的专业技能。”我的团队有幸将人工智能交给世界上一些领先的医学研究人员，并看到他们的工作产生的潜在挽救生命的结果的数量，部分是通过他们获得人工智能。”。

The new findings on the mechanisms of SIDS were among many issues discussed at the Seventh Annual SIDS Summit, hosted by Ramirez, Kahan, and Lavista. Other research discussed included:

关于小岛屿发展中国家机制的新发现是由拉米雷斯、卡汉和拉维斯塔主办的第七届小岛屿发展中国家年度首脑会议上讨论的许多问题之一。讨论的其他研究包括：

A new paper on the connection between birthweight and stillbirth risk. The goal of the research, by Dr. Edwin A. Mitchell, from the University of Auckland, New Zealand, together with Drs. Darren Tanner and Juan M. Lavista Ferres, of Microsoft, is to arm clinicians with more information to use in conjunction with other clinical details, to guide obstetric management and reduce infant mortality..

一篇关于出生体重与死胎风险之间关系的新论文。新西兰奥克兰大学的埃德温·米切尔（EdwinA.Mitchell）博士与微软（Microsoft）的达伦·坦纳（DarrenTanner）博士和胡安·拉维斯塔·费雷斯（JuanM.LavistaFerres）博士共同进行了这项研究，目的是为临床医生提供更多信息，以便与其他临床细节结合使用，指导产科管理并降低婴儿死亡率。。

Emerging laboratory evidence of the adverse impact of vaping on the developing fetus and emerging epidemiological data of its association with preterm birth, a risk factor for SIDS. The presentation, 'Vaping and SIDS: The Developing Story,' by Barbara M. Ostfeld, PhD, professor of pediatrics at Rutgers Robert Wood Johnson Medical School and program director of the SIDS Center of New Jersey, covered why this topic matters, what is known, thus far, and what more we need to learn..

关于vaping对发育中的胎儿产生不利影响的新兴实验室证据及其与早产（小岛屿发展中国家的危险因素）相关的新兴流行病学数据。罗格斯大学罗伯特·伍德·约翰逊医学院（Rutgers Robert Wood Johnson Medical School）儿科教授、新泽西州小岛屿发展中国家中心（SIDS Center of New Jersey）项目主任芭芭拉·奥斯特菲尔德（BarbaraM.Ostfeld）博士（BarbaraM。。

About the Aaron Matthew SIDS Research Guild at Seattle Children's Hospital  The Aaron Matthew SIDS Research Guild at Seattle Children's Hospital was named in honor of Aaron Matthew Kahan, son of Heather Kahan and John B. Kahan. Aaron died of SIDS days after his birth in 2003. The Guild board includes leaders from Seattle Children's Hospital's Integrative Brain Research Institute, Microsoft, Accenture, Marriott Hotels, Adobe, Tata Consulting Services, and VMLY&R..

关于西雅图儿童医院的Aaron Matthew SIDS研究协会西雅图儿童医院的Aaron Matthew SIDS研究协会是为了纪念Heather Kahan和John B.Kahan的儿子Aaron Matthew Kahan而命名的。亚伦于2003年出生后几天死于小岛屿发展中国家。协会董事会成员包括来自西雅图儿童医院综合大脑研究所、微软、埃森哲、万豪酒店、Adobe、塔塔咨询服务和VMLY&R的领导。。

SOURCE Aaron Matthew SIDS Research Guild

资料来源：Aaron Matthew SIDS研究协会