PHILADELPHIA, PA, April 10, 2024 (GLOBE NEWSWIRE) -- The Wistar Institute’s associate professor Mohamed Abdel-Mohsen, Ph.D., along with his team and collaborators, has identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV (PLWH). The findings, taken from a large data study comprising more than 1200 participants, are detailed in the new paper, “Immunoglobulin G N-glycan Markers of Accelerated Biological Aging During Chronic HIV Infection,” published in the journal Nature Communications.

宾夕法尼亚州费城，2024年4月10日（环球通讯社）--威斯塔研究所副教授穆罕默德·阿卜杜勒·莫森博士及其团队和合作者已经确定血液中的糖异常可能会促进HIV感染者（PLWH）的生物衰老和炎症。这项研究结果来自一项由1200多名参与者组成的大型数据研究，发表在《自然通讯》（Nature Communications）杂志上的新论文“慢性HIV感染期间加速生物衰老的免疫球蛋白G N-聚糖标志物”中有详细介绍。

Despite advances in HIV treatment, notably the success of antiretroviral therapy (ART) in suppressing the virus to undetectable levels, HIV remains incurable, with the virus persisting in a dormant state within the body. This chronic presence is linked to long-term health issues, including persistent inflammation and a higher prevalence of aging-related diseases such as cancer and neurocognitive disorders.

尽管艾滋病毒治疗取得了进展，特别是抗逆转录病毒疗法（ART）成功地将病毒抑制到无法检测的水平，但艾滋病毒仍然无法治愈，病毒在体内持续处于休眠状态。这种慢性存在与长期健康问题有关，包括持续的炎症和与衰老相关的疾病（如癌症和神经认知障碍）的患病率更高。

These conditions tend to occur more frequently and at an earlier age in PLWH compared to the general population.  Abdel-Mohsen seeks to understand how chronic viral infection causes this accelerated biological aging, which refers to the body aging faster than one’s chronological years would typically indicate.

与普通人群相比，PLWH中这些疾病的发生频率更高，年龄更早。阿卜杜勒·莫森（AbdelMohsen）试图了解慢性病毒感染如何导致这种加速的生物衰老，这是指身体衰老的速度比一个人的实际年龄通常指示的要快。

By understanding the molecular mechanisms behind accelerated biological aging in people living with chronic viral infections, scientists can begin to formulate strategies to mitigate the negative effects. While many factors in the body can contribute to accelerated biological aging, researchers focused on a novel factor: abnormalities of the human glycome — the totality of the various sugar structures circulating throughout the body.

通过了解慢性病毒感染者加速生物衰老背后的分子机制，科学家可以开始制定减轻负面影响的策略。虽然身体中的许多因素都可能加速生物衰老，但研究人员关注的是一个新因素：人体糖组异常-全身循环的各种糖结构的总和。

Previous studies have established a connection between aging and shifts in the g.

先前的研究已经建立了衰老与g变化之间的联系。