WEDNESDAY, April 10, 2024 -- Premastectomy radiotherapy (PreMRT) and regional node irradiation (RNI) followed by immediate breast reconstruction (IMBR) is feasible and safe, according to a study published online April 5 in JAMA Network Open.Mark V. Schaverien, M.D., from University of Texas MD Anderson Cancer Center in Houston, and colleagues assessed the feasibility and safety of PreMRT followed by mastectomy and IMBR in 49 patients with cT0-T3, N0-N3b breast cancer.The researchers reported that 48 patients underwent mastectomy with IMBR at a median of 23 days after radiotherapy.

2024年4月10日，星期三——根据4月5日在JAMA Network Open在线发布的一项研究，术前放疗（PreMRT）和区域淋巴结照射（RNI），然后立即乳房再造（IMBR）是可行和安全的。休斯顿德克萨斯大学安德森癌症中心的Mark V.Schaverien医学博士及其同事评估了49例cT0-T3、N0-N3b乳腺癌患者术前放疗、乳房切除术和IMBR的可行性和安全性。研究人员报告说，48名患者在放疗后中位数为23天接受了IMBR乳房切除术。

Techniques included microvascular autologous flap reconstruction (41), latissimus dorsi pedicled flap reconstruction (five), and tissue expander placement (two). No complete autologous flap losses were recorded and one patient underwent tissue expander explantation. In total, eight patients (17 percent) had mastectomy skin flap necrosis of the treated breast, with one patient undergoing reoperation.

技术包括微血管自体皮瓣重建（41），背阔肌带蒂皮瓣重建（5）和组织扩张器放置（2）。没有记录到完全的自体皮瓣损失，一名患者接受了组织扩张器移植。总共有8名患者（17%）接受了乳腺切除术，其中1名患者接受了再次手术。

There were no locoregional recurrences or distant metastasis during a median 29.7 months of follow-up.'Our trial represents a pioneering achievement in the United States, demonstrating the safety and effectiveness of this paradigm-shifting treatment sequence for patients with breast cancer,' Schaverien said in a statement.

在中位29.7个月的随访期间，没有局部复发或远处转移。”Schaverien在一份声明中说：“我们的试验代表了美国的一项开创性成就，证明了这种范式转换治疗序列对乳腺癌患者的安全性和有效性。”。

'This sequence not only enhances surgical outcomes but also eliminates the need for patients to defer breast reconstruction surgery, significantly enhancing their quality of life.'Several authors disclosed ties to industry.Abstract/Full TextWhatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox..

“这种顺序不仅提高了手术效果，而且消除了患者推迟乳房再造手术的需要，大大提高了他们的生活质量。”几位作者透露了与该行业的关系。摘要/全文无论您感兴趣的主题是什么，请订阅我们的新闻稿，以便在收件箱中获得Drugs.com的最佳信息。。