THURSDAY, April 25, 2024 -- There is significant global variation in COVID-19 treatment recommendations and disease severity stratifications, according to a study published online April 22 in BMJ Global Health.Mia Cokljat, M.B.Ch.B., from the University of Oxford in the United Kingdom, and colleagues compared the COVID-19 treatment guidelines of each World Health Organization (WHO) member state to the WHO COVID-19 therapeutic guidelines.

2024年4月25日，星期四——根据4月22日在《BMJ全球健康》在线发表的一项研究，新型冠状病毒肺炎的治疗建议和疾病严重程度分层在全球范围内存在显著差异。英国牛津大学医学博士Mia Cokljat及其同事将每个世界卫生组织（WHO）成员国的新型冠状病毒肺炎治疗指南与WHO新型冠状病毒肺炎治疗指南进行了比较。

The analysis included COVID-19 therapeutic national guidelines for 109 of the 194 WHO member states.The researchers found considerable variation in guidelines and in disease severity stratifications. There were also substantial differences in therapeutic recommendations in many national guidelines versus the WHO guidelines.

该分析包括194个世卫组织成员国中109个国家的新型冠状病毒肺炎治疗指南。研究人员发现指南和疾病严重程度分层存在很大差异。许多国家指南与世卫组织指南的治疗建议也存在实质性差异。

In late 2022, 93 percent of national guidelines were recommending at least one treatment that had been proven to be ineffective in large, randomized trials and was not recommended by WHO. For example, corticosteroids were not recommended in severe disease in nearly 10 percent of national guidelines, despite overwhelming evidence of their benefit.

2022年末，93%的国家指南推荐至少一种在大型随机试验中被证明无效的治疗方法，而世卫组织不推荐这种治疗方法。例如，尽管有大量证据表明皮质类固醇对严重疾病有益，但近10%的国家指南不建议使用皮质类固醇治疗严重疾病。

For countries categorized as low-resource settings, national guidelines showed the greatest divergence.'The formalization of processes in the development of national guidelines for COVID-19 and other infectious diseases is essential for ensuring that these guidelines are grounded in the best available evidence,' the authors write.

对于被归类为低资源环境的国家，国家指南显示出最大的分歧。”作者写道，制定新型冠状病毒肺炎和其他传染病国家指南的过程的正式化对于确保这些指南以最佳可用证据为基础至关重要。

'A systematic and structured approach would not only enhance the credibility of the guidelines but could also contribute to their effectiveness in guiding public health interventions, especially in a pandemic setting.'Abstract/Full TextWhatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox..

“系统和结构化的方法不仅可以提高指南的可信度，还可以有助于指导公共卫生干预措施的有效性，特别是在大流行环境中。”摘要/全文无论您感兴趣的主题是什么，请订阅我们的新闻稿，以便在收件箱中获得Drugs.com的最佳信息。。