MANHASSET, N.Y.--(BUSINESS WIRE)--One of the main roles of the spleen is to help the body’s immune system fight infections. The spleen does this through producing and regulating antibodies – antibody production is negatively affected in various conditions, including sepsis and autoimmune diseases like lupus.

纽约曼哈塞特（商业新闻）——脾脏的主要作用之一是帮助身体的免疫系统抵抗感染。脾脏通过产生和调节抗体来实现这一点-抗体的产生在各种情况下都会受到负面影响，包括败血症和狼疮等自身免疫性疾病。

New research published in Science Advances by The Feinstein Institutes for Medical Research scientists shows that activation of the vagus nerve triggers the spleen, thereby regulating the production of antibodies. This research highlights how the nervous system regulates immunity and suggests potential for non-pharmalogical, vagus nerve modulation to treat a variety of diseases, like lupus and sepsis..

范斯坦医学研究院科学家在《科学进展》上发表的最新研究表明，迷走神经的激活会触发脾脏，从而调节抗体的产生。这项研究强调了神经系统如何调节免疫力，并提出了非药物迷走神经调节治疗各种疾病（如狼疮和败血症）的潜力。。

This research –led by Betty Diamond, MD, director of the Institute of Molecular Medicine, in collaboration with Stavros Zanos, MD, PhD, associate professor in the Institute of Bioelectronic Medicine and Barbara Sherry, PhD, professor at the Feinstein Institutes – found that chronic stimulation of the vagus nerve led to a decrease in the production of specific antibodies by splenic B cells that attack and destroy foreign invaders and are able to prevent disease in the future by remembering what those substances look like.

这项研究由分子医学研究所所长贝蒂·戴蒙德（Betty Diamond）领导，与生物电子医学研究所副教授斯塔夫罗斯·萨诺斯（Stavros Zanos）和范斯坦研究所（Feinstein Institutes）教授芭芭拉·雪莉（Barbara Sherry）合作，发现迷走神经的慢性刺激导致脾B细胞产生的特异性抗体减少，这些抗体攻击并摧毁外来入侵者，并能够通过记住这些物质的样子来预防未来的疾病。

This decrease was associated with changes in the way B cells matured and survived in the body, as well as alterations in the functional organization of other immune cells..

这种下降与B细胞在体内成熟和存活方式的改变以及其他免疫细胞功能组织的改变有关。。

“Although we have a good understanding of the role of the vagus nerve in the regulation of the inflammatory response and the innate immune system, this study provides new insights in how the vagus nerve regulates adaptive immunity and the functions of B cells,” said. Dr. Diamond. “Better understanding these mechanisms will elucidate how altered function of the vagus nerve in conditions like sepsis and autoimmune disease may impact immune function and could lead to new therapeutic approaches for these conditions.”.

“虽然我们对迷走神经在调节炎症反应和先天免疫系统中的作用有很好的了解，但这项研究为迷走神经如何调节适应性免疫和B细胞的功能提供了新的见解，”他说。戴蒙德博士。“更好地了解这些机制将阐明在脓毒症和自身免疫性疾病等疾病中迷走神经功能的改变如何影响免疫功能，并可能为这些疾病带来新的治疗方法。”。

In the study, the Feinstein Institutes team discovered that acetylcholine released in response to vagus nerve stimulation (VNS) directly affects B cells by interacting with specific receptors on their surface, thereby altering their ability to produce signaling molecules and mature.

在这项研究中，范斯坦研究所的团队发现，响应迷走神经刺激（VNS）释放的乙酰胆碱通过与B细胞表面的特定受体相互作用直接影响B细胞，从而改变其产生信号分子和成熟的能力。

'Consistent stimulation of the vagus nerve in mice allows us to explore the therapeutic possibilities of bioelectronic medicine in new diseases,” said Dr. Zanos. “These exciting findings warrant further investigation and eventually studies in humans to explore the extent to which vagus nerve stimulation, and other bioelectronic medicine approaches, could become treatment options for diseases involving adaptive immunity.'.

“对小鼠迷走神经的持续刺激使我们能够探索生物电子医学在新疾病中的治疗可能性，”Zanos博士说。“这些令人兴奋的发现值得进一步研究，并最终在人类中进行研究，以探索迷走神经刺激和其他生物电子学方法在多大程度上可能成为涉及适应性免疫的疾病的治疗选择。”。

For more than four decades, Dr. Diamond has dedicated her career to the study of DNA-reactive B cells, autoantibodies and their origin and effect on the body. In May 2022, in recognition of her breakthrough achievements in molecular medicine and original research, The National Academy of Sciences elected Dr.

四十多年来，戴蒙德博士一直致力于研究DNA反应性B细胞、自身抗体及其起源和对身体的影响。2022年5月，为了表彰她在分子医学和原始研究方面取得的突破性成就，美国国家科学院选举她为博士。

Diamond as one of its newest members..

钻石作为其最新成员之一。。

Dr. Zanos’s research focus is on understanding the anatomy and physiology of the vagus nerve and the effects vagus nerve stimulation has in inflammation and cardiovascular diseases. This study builds on a 2021 paper by Dr. Zanos’ group in which they described the development and characterization of the first chronic VNS implant in mice.

Zanos博士的研究重点是了解迷走神经的解剖学和生理学，以及迷走神经刺激对炎症和心血管疾病的影响。这项研究建立在Zanos博士小组2021年的一篇论文的基础上，他们在论文中描述了第一个慢性VNS植入小鼠的开发和表征。

Recently, Dr. Zanos was awarded $6.7 million from the National Institutes of Health to lead a cross-insititonal research team to develop a detailed map of the anatomy of the human vagus nerve and all its more than 100,000 fibers..

最近，美国国立卫生研究院（National Institutes of Health）授予Zanos博士670万美元，以领导一个跨机构研究团队，开发人类迷走神经及其所有100000多种纤维的详细解剖图。。

“While we understand the spleen is an essential part of the immune system, finding that stimulation of the vagus nerve effects the regulation of adaptive immunity by this critical organ is novel and important,' said Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research.

“虽然我们了解脾脏是免疫系统的重要组成部分，但发现刺激迷走神经会影响这一关键器官对适应性免疫的调节是新颖而重要的，”医学博士凯文·特雷西（KevinJ.Tracey）说，他是范斯坦研究所（FeinsteinInstitutes）总裁兼首席执行官，也是卡尔奇家族医学研究杰出主席。

'The research by Drs. Diamond and Zanos highlights the need to continue producing knowledge about bioelectronic medicine's potential to treat or prevent autoimmune disease.”.

“Diamond博士和Zanos博士的研究强调，需要继续产生有关生物电子医学治疗或预防自身免疫性疾病潜力的知识。”。

The Feinstein Institutes for Medical Research is the global scientific home of bioelectronic medicine, which combines molecular medicine, neuroscience, and biomedical engineering. At the Feinstein Institutes, medical researchers use modern technology to develop new device-based therapies to treat disease and injury..

范斯坦医学研究院（Feinstein Institutes for Medical Research）是生物电子医学的全球科学之家，它结合了分子医学、神经科学和生物医学工程。在范斯坦研究院（Feinstein Institutes），医学研究人员利用现代技术开发新的基于设备的疗法来治疗疾病和伤害。。

Building on years of research in molecular disease mechanisms and the link between the nervous and immune systems, our researchers discover neural targets that can be activated or inhibited with neuromodulation devices, like vagus nerve implants, to control the body's immune response and inflammation.

基于多年来对分子疾病机制以及神经和免疫系统之间联系的研究，我们的研究人员发现了可以通过神经调节装置（如迷走神经植入物）激活或抑制的神经靶标，以控制身体的免疫反应和炎症。

If inflammation is successfully controlled, diseases – such as arthritis, pulmonary hypertension, Crohn's disease, inflammatory bowel diseases, diabetes, cancer and autoimmune diseases – can be treated more effectively..

如果炎症得到成功控制，关节炎、肺动脉高压、克罗恩病、炎症性肠病、糖尿病、癌症和自身免疫性疾病等疾病可以得到更有效的治疗。。

Beyond inflammation, using novel brain-computer interfaces, Feinstein Institutes' researchers developed techniques to bypass injuries of the nervous system so that people living with paralysis can regain sensation and use their limbs. By producing bioelectronic medicine knowledge, disease and injury could one day be treated with our own nerves without costly and potentially harmful pharmaceuticals..

除了炎症之外，范斯坦研究所的研究人员还利用新型脑机接口开发了绕过神经系统损伤的技术，使瘫痪患者能够恢复感觉并使用四肢。通过产生生物电子医学知识，疾病和伤害有一天可以用我们自己的神经治疗，而不需要昂贵且潜在有害的药物。。

About the Feinstein Institutes

关于范斯坦学院

The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State. Encompassing 50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its five institutes of behavioral science, bioelectronic medicine, cancer, health system science, and molecular medicine.

范斯坦医学研究院（Feinstein Institutes for Medical Research）是纽约州最大的医疗保健提供者和私人雇主Northwell Health研究院的所在地。范斯坦研究所拥有50个研究实验室、3000个临床研究和5000名研究人员和工作人员，通过其行为科学、生物电子医学、癌症、卫生系统科学和分子医学五个研究所提高了医学创新的标准。

We make breakthroughs in genetics, oncology, brain research, mental health, autoimmunity, and are the global scientific leader in bioelectronic medicine – a new field of science that has the potential to revolutionize medicine. For more information about how we produce knowledge to cure disease, visit http://feinstein.northwell.edu and follow us on LinkedIn..

我们在遗传学、肿瘤学、大脑研究、心理健康、自身免疫方面取得了突破，并且是生物电子医学的全球科学领导者，生物电子医学是一个有可能彻底改变医学的新科学领域。有关我们如何产生治疗疾病的知识的更多信息，请访问http://feinstein.northwell.edu并在LinkedIn上关注我们。。