PHILADELPHIA, PA, May 03, 2024 (GLOBE NEWSWIRE) -- The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma — a serious and often fatal brain cancer — suppresses the immune system so that the tumor can grow unimpeded by the body’s defenses.

宾夕法尼亚州费城，2024年5月3日（环球通讯社）--威斯塔研究所助理教授菲利波·维格里亚博士及其团队发现了胶质母细胞瘤（一种严重且致命的脑癌）如何抑制免疫系统的关键机制，从而使肿瘤不受身体防御的阻碍。

The lab’s discovery was published in the paper, “Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma,” in the journal Immunity. “Our study shows that the cellular mechanisms of cancer’s self-preservation, when sufficiently understood, can be used against the disease very effectively,” said Dr.

该实验室的发现发表在《免疫》杂志上的论文“葡萄糖驱动的组蛋白乳酰化促进胶质母细胞瘤中单核细胞衍生巨噬细胞的免疫抑制活性”。“我们的研究表明，如果充分了解癌症自我保护的细胞机制，可以非常有效地用于对抗疾病，”博士说。

Veglia. “I look forward to future research on metabolism-driven mechanisms of immunosuppression in glioblastoma, and I’m hopeful for all that we will continue to learn about how to best understand and fight this cancer.” Until now, it has been poorly understood how monocyte-derived macrophages and microglia create an immunosuppressive tumor microenvironment in glioblastoma.

维格里亚。“我期待着未来对胶质母细胞瘤中代谢驱动的免疫抑制机制的研究，我希望我们将继续学习如何最好地理解和对抗这种癌症。”到目前为止，人们对单核细胞衍生的巨噬细胞和小胶质细胞如何在胶质母细胞瘤中创造免疫抑制性肿瘤微环境知之甚少。

The Veglia lab investigated the cellular “how” of glioblastoma immunosuppression and identified that, as glioblastoma progressed, monocyte-derived macrophages came to outnumber microglia — which indicated that monocyte-derived macrophages’ eventuality to becoming the majority in the tumor microenvironment was advantageous to the cancer’s goal of evading immune response.

Veglia实验室研究了胶质母细胞瘤免疫抑制的细胞“方式”，发现随着胶质母细胞瘤的进展，单核细胞衍生的巨噬细胞数量超过了小胶质细胞-这表明单核细胞衍生的巨噬细胞可能成为肿瘤微环境中的大多数，这有利于癌症逃避免疫反应的目标。

Indeed, monocyte-derived macrophages, but not microglia, blocked the activity of T cells (immune cells that destroy tumor cells), in preclinical models and patients. The team confirmed this finding when they assessed preclinical models of glioblastoma with artificially reduced numbers of monocyte-derived macrophages.

事实上，在临床前模型和患者中，单核细胞衍生的巨噬细胞而非小胶质细胞阻断了T细胞（破坏肿瘤细胞的免疫细胞）的活性。该团队在评估胶质母细胞瘤的临床前模型时证实了这一发现，该模型人为减少了单核细胞衍生的巨噬细胞的数量。

And as the group expected, the models with fewer mali.

正如该组织所料，马里较少的模式。