SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, today announced the launch of Twist Multiplexed Gene Fragments (MGFs), pools of directly synthesized double-stranded DNA (dsDNA) up to 500 base pairs in length with no limit on sequence number to enable high throughput screening applications..

加利福尼亚州南旧金山市——（商业新闻短讯）——Twist Bioscience Corporation（纳斯达克：TWST）是一家利用其硅平台提供高质量合成DNA的公司，该公司今天宣布推出Twist Multiplexed Gene Fragments（MGF），这是一种直接合成的双链DNA（dsDNA）池，长度可达500个碱基对，序列号不受限制，可以实现高通量筛选应用。。

“Using our chemical synthesis platform we are able to directly synthesize Twist Multiplexed Gene Fragments as fragment pools of up to 500 bp in length. By offering Twist's high-quality gene fragments in a pooled format at prices that scale with the number of sequences, Twist is enabling customers to conduct applications that may have been previously unfeasible or cost-prohibitive, facilitating high-throughput screening in a way that is far more accessible to researchers across industry segments,” said Emily M.

“使用我们的化学合成平台，我们能够直接合成Twist多重基因片段，作为长度高达500 bp的片段库。通过以与序列数量成比例的价格提供Twist的高质量基因片段，Twist使客户能够进行以前可能不可行或成本过高的应用，从而以跨行业研究人员更容易获得的方式促进高通量筛选，”Emily M说。

Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “The capability of pooling directly synthesized fragments with high uniformity and representation allows for rapid screening of diverse targets for CRISPR and genome engineering, facilitates entire antibody variable coding regions for antibody discovery, and supports long coding stretches of protein variants for protein engineering applications.”.

Leproust博士，Twist Bioscience首席执行官兼联合创始人。“汇集具有高度均匀性和代表性的直接合成片段的能力允许快速筛选CRISPR和基因组工程的不同靶标，促进抗体发现的整个抗体可变编码区，并支持用于蛋白质工程应用的蛋白质变体的长编码序列。”。

Twist MGFs are synthesized from customer-defined sequences up to 500 base pairs in length, generating an unlimited number of high-quality DNA fragments in parallel. Twist MGFs encompass a region large enough to span entire antibody variable domains and UTRs, providing customers with a purpose-built product to meet their needs.

Twist-MGF由客户定义的序列合成，长度可达500个碱基对，并行产生无限数量的高质量DNA片段。Twist MGF包含一个足够大的区域，可以跨越整个抗体可变域和UTR，为客户提供专门构建的产品以满足他们的需求。

The expansive coding region also allows for customer customization and multifaceted design options. The pooled format of the fragments enables large-scale high-throughput screening..

扩展的编码区域还允许客户定制和多方面的设计选项。片段的合并格式可以进行大规模的高通量筛选。。

Twist Multiplexed Gene Fragments (MGFs)

Twist多重基因片段（MGFs）

Twist Multiplexed Gene Fragments are pools of customizable double-stranded DNA (dsDNA) between 301-500 base pairs in length. Variant pool size starts at one thousand sequences, with no maximum. Twist MGFs have a turnaround time starting at 8 business days and can be easily integrated into a wide range of workflows for applications including prime editing, ultra-complex CRISPR-based functional screening, peptide and protein engineering, antibody discovery, mRNA vaccine development and massively parallel reporter assays (MPRA)..

Twist多重基因片段是长度在301-500个碱基对之间的可定制双链DNA（dsDNA）库。变体池大小从1000个序列开始，没有最大值。Twist MGF的周转时间从8个工作日开始，可以轻松集成到广泛的工作流程中，用于应用，包括初级编辑，基于超复杂CRISPR的功能筛选，肽和蛋白质工程，抗体发现，mRNA疫苗开发和大规模并行报告分析（MPRA）。。

About Twist Bioscience Corporation

关于Twist Bioscience Corporation

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip.

Twist Bioscience是一家领先且快速发展的合成生物学和基因组学公司，该公司开发了破坏性DNA合成平台，以实现生物学工程的工业化。该平台的核心是一项专有技术，开创了一种通过在硅芯片上“写入”DNA来制造合成DNA的新方法。

Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery.

Twist正在利用其独特的技术制造广泛的基于DNA的合成产品，包括合成基因，用于下一代测序（NGS）制备的工具以及用于药物发现和开发的抗体库。Twist还在DNA和生物制剂药物发现的数字数据存储方面寻求长期机会。

Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research..

Twist生产的产品适用于许多行业，包括医疗保健、工业化学品、农业和学术研究。