GenScript continues to build on its fast and dependable in vitro transcription RNA synthesis service, offering a new self-amplifying RNA format that enhances the potency and efficacy of vaccines, immunotherapies, and gene therapiesPISCATAWAY, N.J., May 13, 2024 /PRNewswire/ -- GenScript Biotech Corporation, a global leader in life science research tools and services, has today announced the expansion of its in vitro transcription (IVT) RNA synthesis portfolio to include self-amplifying RNA (saRNA).

GenScript继续以其快速可靠的体外转录RNA合成服务为基础，提供一种新的自扩增RNA格式，可增强疫苗，免疫疗法和基因治疗的效力和功效。新泽西州，2024年5月13日/PRNewswire/--全球生命科学研究工具和服务领军者GenScript Biotech Corporation今天宣布扩大其体外转录（IVT）RNA合成组合，以包括自扩增RNA（saRNA）。

This cutting-edge addition reinforces GenScript's position at the forefront of IVT RNA technology, offering a new and novel format for researchers working in applications such as vaccine, cancer immunotherapy, and gene or cell therapy development..

这种尖端的添加增强了GenScript在IVT RNA技术前沿的地位，为从事疫苗，癌症免疫疗法以及基因或细胞疗法开发等应用的研究人员提供了一种新的形式。。

GenScript Self-Amplifying RNA

GenScript自扩增RNA

Self-amplifying RNA is a revolutionary RNA platform that can amplify itself within host cells, leading to robust protein expression from a relatively small amount of RNA. This characteristic makes saRNA an attractive option for a variety of therapeutic applications, as it can potentially reduce required dosages, lower production costs, and improve patient outcomes.

自扩增RNA是一种革命性的RNA平台，可以在宿主细胞内扩增自身，从而从相对少量的RNA中产生强大的蛋白质表达。这一特征使saRNA成为各种治疗应用的有吸引力的选择，因为它可以潜在地减少所需剂量，降低生产成本，并改善患者预后。

Recent clinical trial data has shown promising results for the technology in the treatment for advanced malignant solid tumors and rabies. Additionally, in November 2023, the world's first formally approved saRNA-based COVID-19 vaccine was approved by Japan's Ministry of Health, Labour and Welfare (MHLW) for initial and booster vaccinations in adults aged 18 and older..

最近的临床试验数据显示，该技术在治疗晚期恶性实体瘤和狂犬病方面取得了令人鼓舞的结果。此外，2023年11月，日本厚生劳动省（MHLW）批准了世界上第一种正式批准的基于saRNA的新型冠状病毒肺炎疫苗，用于18岁及以上成年人的初次和加强疫苗接种。。

'The introduction of self-amplifying RNA synthesis services marks a significant milestone in GenScript's journey to accelerate the work of researchers and developers in the fast-evolving field of RNA-based therapies,' said Dr. Cedric Wu, VP of the Innovation Center at GenScript USA. 'We are dedicated to providing a streamlined end-to-end service, from gene synthesis to LNP delivery, that addresses the critical needs of our customers.

GenScript美国创新中心副总裁Cedric Wu博士说：“自扩增RNA合成服务的引入标志着GenScript在加速基于RNA的疗法快速发展领域的研究人员和开发人员工作的过程中取得了一个重要的里程碑。我们致力于提供从基因合成到LNP交付的简化端到端服务，以满足客户的关键需求。

The addition of saRNA is a testament to our commitment to innovation and excellence.'.

saRNA的加入证明了我们对创新和卓越的承诺。”。

GenScript's saRNA service is the culmination of extensive research and development efforts, involving the meticulous optimization of production processes, vectors, and specialized modifications, supporting early-stage research to pre-clinical development. Data from early adopters has shown that saRNA synthesized by GenScript exhibits exceptional purity and enhanced protein expression levels and duration at a much lower input than linear mRNA, ensuring reliable performance downstream.Researchers and developers can now leverage GenScript's expertise and robust infrastructure to access custom saRNA synthesis services, with support from GenScript's experienced, Seattle-based technical team at every step of the way.'We understand that the journey from research to therapy is complex and challenging,' said Ray Chen, Ph.D., President of the Life Science Group at GenScript, 'With our comprehensive IVT RNA synthesis portfolio, which now includes self-amplifying RNA, along with our linear mRNA, circular RNA and lipid nanoparticle formulation services, we offer unparalleled support to our partners in their quest to develop next-generation RNA-based therapies.'Where to learn more:.

GenScript的saRNA服务是广泛研究和开发工作的结晶，涉及生产过程，载体和专门修改的细致优化，支持早期研究到临床前开发。来自早期采用者的数据表明，GenScript合成的saRNA表现出异常的纯度，并以比线性mRNA低得多的输入增强了蛋白质表达水平和持续时间，从而确保了下游的可靠性能。研究人员和开发人员现在可以利用GenScript的专业知识和强大的基础设施，在GenScript经验丰富的西雅图技术团队的支持下，在每一步都可以访问定制的saRNA合成服务。”GenScript生命科学小组主席Ray Chen博士说：“我们明白，从研究到治疗的过程是复杂而具有挑战性的，我们的综合IVT RNA合成组合现在包括自扩增RNA，以及我们的线性mRNA，环状RNA和脂质纳米颗粒制剂服务，我们为我们的合作伙伴开发下一代基于RNA的疗法提供了无与伦比的支持。”在哪里了解更多：。

Watch GenScript's new RNA Production Services video

观看GenScript的新RNA生产服务视频

Watch GenScript's new circRNA and saRNA animation

观看GenScript的新circRNA和saRNA动画

Visit the GenScript saRNA microsite

访问GenScript saRNA microsite

Set up a consultation with a GenScript scientist

与GenScript科学家进行咨询

About GenScriptGenScript Biotech Corporation (HK.1548) is a world leader in technologies and services for life science R&D and manufacture. Built upon its solid DNA synthesis technology, the company comprises four major business units: a life-science services and products business unit, a biologics contract development and manufacturing organization (CDMO) business unit, an industrial synthetic products business unit, and an integrated global cell therapy company.

关于Genscript Genscript Biotech Corporation（香港1548）是生命科学研发和制造技术和服务的世界领导者。该公司以其固体DNA合成技术为基础，由四个主要业务部门组成：生命科学服务和产品业务部门、生物制品合同开发和制造组织（CDMO）业务部门、工业合成产品业务部门和全球综合细胞治疗公司。

GenScript accelerates scientific discovery and therapeutic breakthrough with its customers. Since its founding in New Jersey, USA in 2002, GenScript has expanded its operations to serve more than 200,000 customers across 100 countries with a dedicated team of 6,900 employees. As of December 31, 2023, 87,700 peer-reviewed journal articles worldwide had cited GenScript 's services and products.

GenScript加速了其客户的科学发现和治疗突破。自2002年在美国新泽西州成立以来，GenScript凭借一支由6900名员工组成的专门团队，扩大了业务范围，为100个国家的20多万客户提供服务。截至2023年12月31日，全球共有87700篇同行评审期刊文章引用了GenScript的服务和产品。

Guided by its mission to make people and nature healthier through biotechnology, GenScript strives to become the most trustworthy biotech company in the world.For more information, please visit GenScript Biotech's official website https://www.genscript.comKay ChuangHead of Marketing, GenScriptkay.chuang@genscript.comSOURCE GenScript Biotech Corporation.

在通过生物技术使人类和自然更健康的使命指导下，GenScript努力成为世界上最值得信赖的生物技术公司。有关更多信息，请访问GenScript Biotech的官方网站https://www.genscript.comKay市场营销总监，GenScriptkay.chuang@genscript.comSOURCEGenScript生物技术公司。