NEW YORK, May 21, 2024 /PRNewswire/ --The DeGregorio Family Foundation with support from the Esophageal Cancer Awareness Association has awarded $100,000 to Dr. Anthony Capobianco, PhD, Professor at The DeWitt Daughtry Family Department of Surgery and the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.  The Grant is named in memory of Michael F.

2024年5月21日，纽约/PRNewswire/——在食管癌意识协会的支持下，DeGregorio家庭基金会向DewittDaughtry家族外科和迈阿密大学米勒医学院Sylvester综合癌症中心教授AnthonyCapobianco博士授予了10万美元。这项拨款是为了纪念迈克尔·F。

Price, the noted value investor and philanthropist, who was an early supporter of the Foundation. .

普莱斯是著名的价值投资者和慈善家，也是该基金会的早期支持者。。

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Dr. Anthony Capobianco

Anthony Capobianco博士

Dr. Capobianco's research is dedicated to targeting cancer stem cell populations by dual inhibition of the Notch and Wnt pathways in upper GI cancers with novel experimental drugs being developed by StemSynergy Therapeutics.  This funding is in addition to $75,000 awarded in 2023 and could increase, depending on results..

Capobianco博士的研究致力于通过双重抑制上消化道癌症中的Notch和Wnt途径来靶向癌症干细胞群，StemSynergy Therapeutics正在开发新的实验药物。这项资金是在2023年授予的75000美元之外的，根据结果可能会增加。。

The primary cause of death from cancer is due to resistance to standard therapy and metastasis.  It is widely accepted that these properties of cancer are driven by distinct populations of cells termed cancer stem cells (CSCs).  Through Dr. Capobianco's research he has identified two cell components that are critical to the maintenance of these CSCs: Wnt and Notch developmental signaling pathways..

癌症死亡的主要原因是对标准治疗和转移的抵抗力。人们普遍认为，癌症的这些特性是由称为癌症干细胞（CSC）的不同细胞群驱动的。通过Capobianco博士的研究，他确定了两种对维持这些CSC至关重要的细胞成分：Wnt和Notch发育信号通路。。

'My research funded in part by the Foundation has demonstrated that we can eliminate these two populations using pathway-specific inhibitors – two drugs, NADI-351, SSTC3. Ablation of both populations had a dramatic increase in efficacy,' said Dr. Capobianco. 'To further advance these results and to provide a model for future clinical protocol, we added a standard of care chemotherapeutic Docetaxel.

“我的研究部分由基金会资助，证明我们可以使用途径特异性抑制剂消除这两个人群-两种药物，NADI-351，SSTC3。卡波比安科博士说，两种人群的消融都有显著的疗效提高为了进一步推进这些结果并为未来的临床方案提供模型，我们添加了标准护理化疗多西紫杉醇。

Addition of this drug to the protocol appeared to work with the Notch and WNT inhibitors to improve the durability of the treatment.' The current funding is to better understand the two drugs in combination with chemotherapy in patient-derived xenograft mouse models.  These preclinical studies will lay the foundation for future clinical trials.Said Dr.

在方案中添加这种药物似乎与Notch和WNT抑制剂一起起作用，以提高治疗的持久性。”目前的资金是为了更好地了解这两种药物与患者来源的异种移植小鼠模型中的化疗相结合。这些临床前研究将为未来的临床试验奠定基础。博士说。

Capobianco, 'The grant from the DeGregorio Family Foundation has been very instrumental in providing the discovery research to find new cures for gastroesophageal cancer.'In 2020, gastric and esophageal cancers combined killed over 1.3 million people worldwide.  Patients continue to face poor prognoses following gastric and esophageal cancer diagnoses due to their chemo-resistant behavior and ability to metastasize.

卡波比安科（Capobianco）说，DeGregorio家庭基金会（Family Foundation）的资助在提供发现研究以寻找胃食管癌的新疗法方面发挥了非常重要的作用2020年，全世界胃癌和食道癌共导致130多万人死亡。由于其化疗耐药行为和转移能力，患者在胃癌和食管癌诊断后继续面临不良预后。

The DeGregorio Family Foundation, founded in 2006 after a 10th member of the DeGregorio family died of stomach cancer, has raised more than $10 million to fund innovative research focused on curing gastroesophageal cancer.  'We are honored to continue to support this research to test destroying the cancer stem cell population in upper GI with novel experimental drugs,' concluded Lynn DeGregorio, President and Founder.The DeGregorio Family Foundation funds innovative research focused on curing gastric and esophageal cancers—click here to donate and...

DeGregorio家族基金会成立于2006年，是在DeGregorio家族的第10位成员死于胃癌之后成立的，该基金会筹集了1000多万美元，用于资助专注于治疗胃食管癌的创新研究。总裁兼创始人林恩·德莱戈里奥（LynnDegregorio）总结道：“我们很荣幸继续支持这项研究，以测试用新型实验药物破坏上消化道癌症干细胞群的效果。”。DeGregorio家庭基金会资助了一项专注于治疗胃癌和食道癌的创新研究。点击这里捐赠并。。。

Help us turn fact into fiction™.SOURCE DeGregorio Family Foundati.

帮助我们将事实变为虚构™。来源DeGregorio Family Foundati。