FRIDAY, May 24, 2024 -- Antihypertensive drugs are associated with an increased risk for eczematous dermatitis in older adults, and the effect sizes are largest for diuretics and calcium channel blockers, according to a study published online May 22 in JAMA Dermatology.Morgan Ye, M.P.H., from the University of California in San Francisco, and colleagues examined whether antihypertensive drug use is associated with eczematous dermatitis in a longitudinal cohort study of individuals aged 60 years and older without eczematous dermatitis at baseline.The researchers found that the overall prevalence of eczematous dermatitis was 6.7 percent among 1,561,358 older adults during a median follow-up of six years.

2024年5月24日，星期五——根据5月22日《美国医学会皮肤病学》在线发表的一项研究，抗高血压药物与老年人湿疹性皮炎的风险增加有关，利尿剂和钙通道阻滞剂的作用量最大。来自旧金山加利福尼亚大学的Morgan Ye，M.P.H.及其同事在一项纵向队列研究中研究了抗高血压药物的使用是否与湿疹性皮炎有关，该研究对60岁及以上的基线时没有湿疹性皮炎的个体进行了研究。研究人员发现，在中位随访6年的1561358名老年人中，湿疹性皮炎的总患病率为6.7%。

The incidence of eczematous dermatitis was higher among those receiving versus those not receiving antihypertensive drugs (12 versus 9 of 1,000 person-years of follow-up). Participants who received any antihypertensive drugs had a significantly increased risk for any eczematous dermatitis in adjusted analyses (hazard ratio, 1.29).

接受抗高血压药物治疗的患者与未接受抗高血压药物治疗的患者相比，湿疹性皮炎的发生率更高（1000人年随访中有12人比9人）。在调整后的分析中，接受任何抗高血压药物的参与者患湿疹性皮炎的风险显着增加（风险比为1.29）。

When assessing each antihypertensive drug class individually, the largest effect sizes were seen for diuretics and calcium channel blockers, while the effect sizes were smallest for angiotensin-converting enzyme inhibitors and β-blockers (hazard ratios, 1.21, 1.16, 1.02, and 1.04, respectively).'Although additional research is needed to understand the mechanisms underlying the association of antihypertensive drug use and eczematous dermatitis, these data could be helpful to clinicians to guide clinical management when an older patient presents with eczematous dermatitis,' the authors write.Two authors disclosed ties to the pharmaceutical industry.Abstract/Full Text (subscription or payment may be required)Whatever your topic of interest, subscr.

当单独评估每种抗高血压药物类别时，利尿剂和钙通道阻滞剂的作用量最大，而血管紧张素转换酶抑制剂和β受体阻滞剂的作用量最小（危险比分别为1.21、1.16、1.02和1.04）。'作者写道，尽管需要进一步的研究来了解抗高血压药物使用与湿疹性皮炎之间关联的潜在机制，但这些数据可能有助于临床医生在老年患者出现湿疹性皮炎时指导临床管理。两位作者透露了与制药行业的关系。摘要/全文（可能需要订阅或付款），无论您感兴趣的主题是什么，subscr。