AbstractGlutarimide-containing polyketides usually exhibit anti-fungi activity, which was well exampled by cycloheximide. In our work, three new polyketide structures, 12-amidestreptimidone (1), 12-carboxylstreptimidone (2) and 3-(5S,8R)-(2-amino-2-oxoethyl-2’-methoxy-2’-oxoethyl)-8,10-dimethyl-7-oxododeca-5-hydroxy-9E,11-diolefin (3) were isolated from Streptomyces sp.

摘要含戊二酰亚胺的聚酮化合物通常具有抗真菌活性，环己酰亚胺就是一个很好的例子。在我们的工作中，从链霉菌属（Streptomyces sp。）中分离出三种新的聚酮化合物结构，12-酰胺基庚亚胺酮（1），12-羧基链霉酰亚胺酮（2）和3-（5S，8R）-（2-氨基-2-氧乙基-2'-甲氧基-2'-氧乙基）-8,10-二甲基-7-氧代癸-5-羟基-9E，11-二烯烃（3）。

JCM 4793. 3 without the glutarimide moiety is not active against fungi as expected, while 1 bearing the amide moiety is much more active than its carboxylic form 2. Here we report the isolation, structural elucidation, antifungal activity, and proposed biosynthesis pathway of 1–3..

JCM 4793。没有戊二酰亚胺部分的3对真菌没有预期的活性，而带有酰胺部分的1比其羧基形式2更具活性。在这里，我们报告了1-3的分离，结构阐明，抗真菌活性和拟议的生物合成途径。。

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Download referencesAcknowledgementsThis research was supported financially by grants from the National Science Foundation of China (22177050), the Xingdian Talent Support Program of Yunnan Province (XDYC-QNRC-2022-0774), Yunnan Provincial Science and Technology Department (202301AT070323), and Youth Innovation Promotion Association CAS to (2022395).Author informationAuthor notesThese authors contributed equally: Mingming Cao, Yi Zhao, Yan-Yun CheAuthors and AffiliationsFaculty of Pharmacy, Yunnan University of TCM, Kunming, Yunnan, 650500, ChinaLin-Fang Tang, Wu-Lai Jihuo, Zi-Kang Zhao, Yi Zhao & Yan-Yun CheState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, ChinaLin-Fang Tang, Wu-Lai Jihuo, Pei-Dong Shi, Cui-Xuan Mei, Zi-Kang Zhao, Yuan Chen, Ying-Tong Di, Xiao‑Jiang Hao & Mingming CaoAuthorsLin-Fang TangView author publicationsYou can also search for this author in.

下载参考文献致谢本研究得到了国家科学基金（22177050）、云南省兴电人才支持计划（XDYC-QNRC-2022-0774）、云南省科学技术厅（202301AT070323）和中国科学院青年创新促进会to（2022395）的资助。作者信息作者注意到这些作者做出了同样的贡献：曹明明，赵毅，赵燕云。作者和附属机构云南中医药大学药学院，云南昆明，650500，中国林方堂，吴来基火，赵子康，赵毅和赵燕云。中国科学院昆明植物研究所中国西部植物化学与植物资源重点实验室，云南昆明，650201，中国林方堂，吴来基火，裴东石，崔玄梅，赵子康，袁晨，尹同迪，肖江浩和曹明明。作者出版物你也可以搜索林方堂作者在。

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Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationSupporting InformationRights and permissionsReprints and permissionsAbout this articleCite this articleTang, LF., Jihuo, WL., Shi, PD.

Additional informationPublisher的注释Springer Nature在已发布的地图和机构隶属关系中的管辖权主张方面保持中立。补充信息支持信息权利和许可打印和许可本文引用本文Tang，LF。，基霍，WL。，Shi，PD。

et al. Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793..

等。从链霉菌属JCM 4793中分离出的含细胞毒性戊二酰亚胺的聚酮化合物。。

J Antibiot (2024). https://doi.org/10.1038/s41429-024-00743-1Download citationReceived: 04 March 2024Revised: 30 April 2024Accepted: 06 May 2024Published: 30 May 2024DOI: https://doi.org/10.1038/s41429-024-00743-1Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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