The U.S. Centers for Disease Control and Prevention (CDC) has recently issued updated clinical guidelines recommending the use of doxycycline post-exposure prophylaxis (doxy PEP) as a preventive measure for bacterial sexually transmitted infections (STIs). The new recommendations specifically target gay and bisexual men as well as transgender women who have previously had an STI within the past year and are at a high risk of reinfection.

美国疾病控制与预防中心（CDC）最近发布了最新的临床指南，建议使用强力霉素暴露后预防（doxy-PEP）作为细菌性传播感染（STI）的预防措施。新的建议专门针对过去一年内曾感染性病且再次感染风险高的男同性恋和双性恋男性以及变性女性。

This intervention is aimed at reducing the risk of contracting bacterial STIs, such as syphilis, chlamydia, and gonorrhea.According to the CDC, taking 200 milligrams of doxycycline within 72 hours after sexual activity has shown promising results in reducing the incidence of syphilis and chlamydia infections by over 70% and gonococcal infections by approximately 50%.

这种干预措施旨在降低感染细菌性性病的风险，如梅毒、衣原体和淋病。据疾病预防控制中心称，在性活动后72小时内服用200毫克强力霉素已显示出令人鼓舞的结果，可将梅毒和衣原体感染的发生率降低70%以上，淋菌感染的发生率降低约50%。

In fact, the San Francisco Department of Public Health began recommending doxy-PEP for gay and bisexual men and transgender women starting in October 2022. Recent research from the city has indicated that a single dose of doxycycline taken post-exposure has led to a 50% reduction in both chlamydia and syphilis cases, further reinforcing the potential effectiveness of this approach..

事实上，旧金山公共卫生部从2022年10月开始为男同性恋、双性恋和变性女性推荐doxy PEP。该市最近的研究表明，暴露后服用单剂量强力霉素可使衣原体和梅毒病例减少50%，进一步增强了这种方法的潜在有效性。。

While the use of doxy PEP has shown promise in controlling the spread of STIs in high-risk groups, the CDC also acknowledges concerns about the potential long-term effects of increased antibiotic usage and the development of antimicrobial resistance. As a result, the agency plans to closely monitor the adoption of doxy PEP, its impact on bacterial STI rates, national doxycycline prescription trends, and antimicrobial resistance patterns.

虽然doxy PEP的使用在控制高危人群性病传播方面显示出前景，但CDC也承认对抗生素使用增加和抗菌素耐药性发展的潜在长期影响的担忧。因此，该机构计划密切监测doxy PEP的采用情况，其对细菌性传播感染率的影响，国家强力霉素处方趋势以及抗菌药物耐药性模式。

This ongoing evaluation will allow the CDC to adjust recommendations based on the latest evidence and developments in this area.It's important to note that while previous studies have demonstrated the effectiveness of doxycycline in these specific groups, further evidence is needed before recommending the widespread use of doxy PEP for all adult Americans.

这项持续的评估将使疾病预防控制中心能够根据这一领域的最新证据和发展调整建议。值得注意的是，虽然先前的研究已经证明强力霉素在这些特定人群中的有效性，但在建议所有成年美国人广泛使用强力霉素PEP之前，还需要进一步的证据。

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