SHENZHEN, China, June 6, 2024 /PRNewswire/ -- MGI Tech Co., Ltd. ('MGI'), a company committed to building core tools and technologies that drive innovation in life science, today announced a highly efficient whole workflow solution for agricultural large-scale Low-pass whole genome sequencing (Low-pass WGS) based on its proprietary DNBSEQ™ platforms during this year's International Plant and Animal Genome Conference Asia (PAG Asia 2024), taking place on June 5-7 in Shenzhen, China..

中国深圳，2024年6月6日/PRNewswire/--MGI科技有限公司（“MGI”）是一家致力于构建推动生命科学创新的核心工具和技术的公司，今天在6月5日至7日于中国深圳举行的今年亚洲国际动植物基因组会议（PAG Asia 2024）上，宣布了一种基于其专有DNBSEQ™平台的农业大规模低通全基因组测序（Low-pass WGS）高效全工作流解决方案。。

The new solution consists of an automated full-process product portfolio designed for large-scale molecular breeding genotyping of agricultural diploid species. The full workflow covers extraction, library preparation, sequencing, and SNP & InDel calling.

新的解决方案包括一个自动化的全过程产品组合，用于农业二倍体物种的大规模分子育种基因分型。完整的工作流程包括提取，文库制备，测序以及SNP＆InDel调用。

The new MGIEasy Large-scale PCR-Free FS Library Prep Set for Low-pass WGS, available in two specifications, 96RXN and 384RXN, is designed specifically for Low-pass WGS applications with a new plate-based library preparation reagent module. Compared with common PCR-free library preparation sets on the market, this kit cuts the purification step and completes library construction in three easy steps, reducing the time and consumables required..

用于低通WGS的新型MGIEasy大规模无PCR FS文库制备套件有96RXN和384RXN两种规格，专门为低通WGS应用而设计，带有新的基于平板的文库制备试剂模块。与市场上常见的无PCR文库制备装置相比，该试剂盒减少了纯化步骤，并通过三个简单的步骤完成文库构建，减少了所需的时间和耗材。。

In combination with MGI's advanced automation platforms, the Low-pass WGS solution breaks through the limit on throughput as seen in ordinary library preparation. It utilizes the fewer number of automated tools to match ultra-high throughput, as while maintaining a high degree of automation. As a result, large-scale library preparation can be done in a short time, at low cost, and with great automation friendliness..

结合MGI的高级自动化平台，低通WGS解决方案突破了普通文库制备中的吞吐量限制。它利用较少数量的自动化工具来匹配超高吞吐量，同时保持高度自动化。因此，大规模的图书馆准备可以在短时间内完成，成本低，并且自动化程度高。。

For sequencing, the product bundles for high throughput and medium throughput Low-pass WGS feature the ultra-high-throughput DNBSEQ-T7 sequencer and the versatile DNBSEQ-G400 benchtop sequencer respectively, empowering large-scale agricultural genomics research projects in a short time.

对于测序，高通量和中通量低通WGS的产品包分别具有超高通量DNBSEQ-T7测序仪和多功能DNBSEQ-G400台式测序仪，可在短时间内实现大规模农业基因组学研究项目。

The initial workflow released includes a pig reference panel and a data analysis software that has been based on GLIMPSE2, allowing users to perform pig genotyping without having to build their own database. Free format conversion service is also available for users with an existing reference panel to be compatible with the analysis software..

发布的最初工作流程包括一个猪参考面板和一个基于GLIMPSE2的数据分析软件，使用户无需建立自己的数据库即可进行猪基因分型。免费格式转换服务也可用于现有参考面板与分析软件兼容的用户。。

'Since genome selection was widely used in agricultural breeding, genotyping tools went through several iterations, sequencing technology gradually shows its irreplaceable advantages,' said Duncan Yu, President of MGI. 'Low-pass WGS has been applied in both animal and plant breeding, but not without implementation challenges.

MGI总裁邓肯·余（DuncanYu）说，由于基因组选择在农业育种中得到广泛应用，基因分型工具经历了多次迭代，测序技术逐渐显示出其不可替代的优势低通WGS已应用于动物和植物育种，但并非没有实施挑战。

Our new total solution for large-scale pig breeding addresses these user pain points and promises flexible automation needs, simplified library preparation, high throughput sequencing, and efficient data processing.'.

我们针对大规模养猪的新整体解决方案解决了这些用户的难点，并承诺了灵活的自动化需求，简化了文库制备，高通量测序和高效的数据处理。”。

Bolstered by MGI's powerhouse instruments, this agricultural Low-pass WGS solution has a daily throughput of 96 to 1,536 samples and annual throughput of 24,000 to 384,000 samples (based on the 1.0X depth of a pig genome and an average sample data output of 3G). It has also obtained high-accuracy SNP results from 0.5~1X Low-pass in pig ear tissue samples, demonstrating 98.4% consistency with the SNP array and 98.1% with 50X WGS.

在MGI的发电站仪器的支持下，这种农业低通WGS解决方案的日吞吐量为96至1536个样本，年吞吐量为24000至384000个样本（基于猪基因组的1.0倍深度和3G的平均样本数据输出）。它还从猪耳组织样品中的0.5〜1X低通获得了高精度SNP结果，与SNP阵列的一致性为98.4%，与50X WGS的一致性为98.1%。

Together with MGI's self-developed MegaBOLT bioinformatics analysis accelerator, it can analyse 192 pig 1.0X samples daily, and approximately 1,536 per day with ZBOLT Pro..

与MGI自主开发的MegaBOLT生物信息学分析加速器一起，它每天可以分析192头猪1.0倍的样本，使用ZBOLT Pro每天大约可以分析1536个样本。。

Compared to traditional genotyping by microarray, MGI's new solution offers genome-wide data at the same cost but captures a broader range of genetic variation, enhances the discovery of new variants, and increases the statistical power of genome-wide studies, all while eliminating high design and start-up costs associated with microarrays.

与传统的微阵列基因分型相比，MGI的新解决方案以相同的成本提供了全基因组数据，但捕获了更广泛的遗传变异，增强了新变异的发现，并提高了全基因组研究的统计能力，同时消除了与微阵列相关的高设计和启动成本。

The dynamic features of this solution enable continuous updates and optimizations in genomic analyses..

该解决方案的动态功能使基因组分析能够不断更新和优化。。

'As a provider of core tools in life science, MGI is committed to providing agricultural scientists and breeders with high-quality, convenient, and reliable genome products, while actively driving the growth of agricultural research and industry,' added Yu.

“作为生命科学核心工具的提供商，MGI致力于为农业科学家和育种者提供高质量，方便和可靠的基因组产品，同时积极推动农业研究和产业的发展，”余补充道。

The Low-pass WGS product and workflow will be available for orders starting on June 30th. For further information on MGI's latest whole workflow agricultural large-scale Low-pass WGS solution, please visit mgi-tech.com.

自6月30日起，低通WGS产品和工作流程将可用于订单。有关MGI最新的全工作流农业大规模低通WGS解决方案的更多信息，请访问MGI-tech.com。

About MGI

关于MGI

MGI Tech Co., Ltd. (or its subsidiaries, together referred to MGI) is committed to building core tools and technologies that drive innovation in life science. Our focus lies in research & development, manufacturing, and sales of instruments, reagents, and related products in the field of life science and biotechnology.

MGI科技有限公司（或其子公司，统称MGI）致力于构建推动生命科学创新的核心工具和技术。我们专注于生命科学和生物技术领域仪器、试剂和相关产品的研发、制造和销售。

We provide real-time, multi-omics, and full spectrum of digital equipment and systems for precision medicine, agriculture, healthcare, and various other industries. Founded in 2016, MGI has grown into a leader in life science, serving customers across six continents and have established research, manufacturing, training, and after-sales service facilities globally.

我们为精准医学、农业、医疗保健和各种其他行业提供实时、多组学和全方位的数字设备和系统。MGI成立于2016年，现已成长为生命科学领域的领导者，为六大洲的客户提供服务，并在全球建立了研究、制造、培训和售后服务设施。

MGI stands out as one of the few companies capable of independently developing and mass-producing clinical-grade gene sequencers with varying throughput capacities, ranging from Gb to Tb levels. With unparalleled expertise, cutting-edge products, and a commitment to global impact, MGI continues to shape the trajectory of life sciences into the future.

MGI是少数能够独立开发和大规模生产临床级基因测序仪的公司之一，其吞吐量从Gb到Tb不等。凭借无与伦比的专业知识、尖端产品和对全球影响力的承诺，MGI继续塑造生命科学未来的发展轨迹。

To learn more, please visit mgi-tech.com/, LinkedIn, X, and YouTube..

要了解更多信息，请访问mgi-tech.com/、LinkedIn、X和YouTube。。

SOURCE MGI TECH

来源MGI技术