精神分裂症患者大脑皮层形态相似网络的拓扑异常-动脉网

Nature：Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia

Nature 等信源发布 2024-06-17 15:28

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AbstractA morphometric similarity (MS) network can be constructed using multiple magnetic resonance imaging parameters of each cortical region. An MS network can be used to assess the similarity between cortical regions. Although MS networks can detect microstructural alterations and capture connections between histologically similar cortical areas, the influence of schizophrenia on the topological characteristics of MS networks remains unclear.

摘要可以使用每个皮质区域的多个磁共振成像参数构建形态相似性（MS）网络。MS网络可用于评估皮质区域之间的相似性。尽管MS网络可以检测微观结构的改变并捕获组织学上相似的皮质区域之间的连接，但精神分裂症对MS网络拓扑特征的影响仍不清楚。

We obtained T1- and diffusion-weighted images of 239 healthy controls and 190 individuals with schizophrenia to construct the MS network. Group comparisons of the mean MS of the cortical regions and subnetworks were performed. The strengths of the connections between the cortical regions and the global and nodal network indices were compared between the groups.

我们获得了239名健康对照者和190名精神分裂症患者的T1和弥散加权图像，以构建MS网络。对皮质区域和子网络的平均MS进行了组比较。比较各组之间皮质区域与全局和节点网络指数之间的连接强度。

Clinical associations with the network indices were tested using Spearman’s rho. Compared with healthy controls, individuals with schizophrenia had significant group differences in the mean MS of several cortical regions and subnetworks. Individuals with schizophrenia had both superior and inferior strengths of connections between cortical regions compared with those of healthy controls.

使用Spearman的rho测试了与网络指数的临床关联。与健康对照组相比，精神分裂症患者在几个皮层区域和子网络的平均MS上存在显着的群体差异。。

We observed regional abnormalities of the MS network in individuals with schizophrenia regarding lower centrality values of the pars opercularis, superior frontal, and superior temporal areas. Specific nodal network measures of the right pars opercularis and left superior temporal areas were associated with illness duration in individuals with schizophrenia.

我们观察到精神分裂症患者MS网络的区域异常，涉及鳃部，额上和颞上区域的中心性较低。右侧鳃盖部和左侧颞上区的特定节点网络测量值与精神分裂症患者的疾病持续时间相关。

We identified regional abnormalities of the MS network in schizophrenia with the left superior temporal area possibly being a key region in topological organization and cortical connections..

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IntroductionDespite the enormous socioeconomic burden of schizophrenia1, the neurobiological background of the etiology and pathophysiology of schizophrenia is still elusive. Structural abnormalities of brain regions in individuals with schizophrenia have been consistently reported; however, the individual results vary2.

引言尽管精神分裂症的社会经济负担巨大，但精神分裂症病因和病理生理学的神经生物学背景仍然难以捉摸。精神分裂症患者大脑区域的结构异常一直有报道；但是，个人结果各不相同2。

Dysconnectivity among brain regions has been hypothesized to be the primary pathophysiology for schizophrenia, suggesting that abnormal connections among cortical and subcortical regions contribute to clinical symptoms of schizophrenia, together with structural and functional changes in individual brain regions.

。

Accordingly, abnormalities in intra- and inter-networks in individuals with schizophrenia have drawn increasing attention3. A meta-analysis of resting-state functional connectivity in individuals with schizophrenia reported an imbalance in connections among large-scale brain networks and revealed the core role of the ventral attention network in a disconnected brain network model4.

因此，精神分裂症患者的内部和内部网络异常引起了越来越多的关注3。。

Consequently, the abnormalities in individual brain regions and their connections should be considered in tandem to clarify the neural mechanisms involved in schizophrenia.The brain network can be conceptualized as a graph in which nodes are brain regions, and edges are their connections. Graph-based network analysis has the advantage of resulting in several network properties reflective of the segregation and integration of individual brain regions5.

因此，应同时考虑单个大脑区域及其连接的异常，以阐明精神分裂症的神经机制。大脑网络可以概念化为一个图形，其中节点是大脑区域，边缘是它们的连接。基于图的网络分析的优点是可以产生反映单个大脑区域分离和整合的几种网络特性5。

The topological characteristics of brain networks in individuals with schizophrenia include less efficient wiring networks and a low prevalence of local clustering and hierarchical organization6. The results indicate disrupted network organization with widespread and local network disturbances in individuals with schizop.

精神分裂症患者大脑网络的拓扑特征包括布线网络效率较低，局部聚类和分层组织的发生率较低6。结果表明，精神分裂症患者的网络组织受到破坏，并伴有广泛的局部网络干扰。

Data availability

数据可用性

The data of this study are available from the corresponding author upon reasonable request.

本研究的数据可根据合理要求从通讯作者处获得。

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Moreover, investigators from each study site contributed to the design and implementation of the projects and provided the data. SWJ was supported by a National Research Foundation of Korea grant (NRF-2021R1F1A11057227). JL was supported by National Research Foundation of Korea grants (NRF-2012R1A1006514 and NRF-2017R1D1A1B03032707) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI22C0108).Author informationAuthors and AffiliationsDepartment of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of KoreaSung Woo Joo, Woohyeok Choi, Sun Min Kim & Jungsun LeeDepartment of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of KoreaYoung Tak JoDepartment of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of KoreaSo Young YooBrain Laboratory, Department of Psychiatry, University of California San Diego, School of Medicine, San Diego, California, USASoohyun JoeAuthorsSung Woo JooView author publicationsYou can also search for this autho.

此外，每个研究地点的调查人员都为项目的设计和实施做出了贡献，并提供了数据。SWJ得到了韩国国家研究基金会的资助（NRF-2021R1F1A11057227）。JL得到了韩国国家研究基金会拨款（NRF-2012R1A11006514和NRF-2017R1D1A1B03032707）和韩国健康技术研发项目的支持，该项目由韩国卫生与福利部资助的韩国健康产业发展研究所（KHIDI）资助（资助号：HI22C0108）。。

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PubMed Google ScholarContributionsS.W.J.: Conceptualization, Formal analysis, Funding acquisition, Methodology, Visualization, and Writing – original draft. Y.T.J.: Methodology and Writing – review & editing. W.C.: Data curation. S.M.K.: Writing – review & editing. S.Y.Y.: Writing – review & editing.

PubMed谷歌学术贡献。W、 J.：概念化，形式分析，资金获取，方法论，可视化和写作-原稿。Y、 T.J.：方法论和写作-评论和编辑。W、 C.：数据管理。S、 M.K.：写作-评论和编辑。S、 Y.Y.：写作-评论和编辑。

S.J.: Supervision. Jungsun Lee: Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing.Corresponding authorCorrespondence to.

S、 J.：监督。Lee Jungsun：概念化，资金获取，方法论，监督，写作-评论和编辑。对应作者对应。

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Reprints and permissionsAbout this articleCite this articleJoo, S.W., Jo, Y.T., Choi, W. et al. Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia.

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