Engineered Camelina is intended to enable the land-based production of omega-3 oils used in aquafeed, petfood and human nutrition

经过工程改造的Camelina旨在实现陆地生产用于水产饲料、宠物食品和人类营养的ω-3油

WOBURN, Mass. and HARPENDEN, United Kingdom, June 17, 2024 (GLOBE NEWSWIRE) -- Yield10 Bioscience, Inc. (OTC:YTEN) (“Yield10” or the “Company”), an agricultural bioscience company, today announced that U.K.-based Rothamsted Research Limited (“Rothamsted”) has granted to the Company an exclusive global, commercial license to advanced technology for producing sustainable omega-3 products in Camelina sativa (“Camelina”).

马萨诸塞州沃本市和英国哈彭登市，2024年6月17日（环球通讯社）--农业生物科学公司Yield10 Bioscience，Inc.（OTC:YTEN）（“Yield10”或“公司”）今天宣布，总部位于英国的Rothamsted Research Limited（“Rothamsted”）已向该公司授予全球独家商业许可证，以获得先进技术，用于在Camelina sativa（“Camelina”）生产可持续的ω-3产品。

Yield10 is executing a plan to use engineered Camelina to commercially produce omega-3 oil and meal products targeting the aquafeed, petfood, and nutritional markets for omega-3 fatty acids. In consideration for the commercial license, Yield10 is expected to pay certain license fees, future milestone payments, and royalties based on commercialization of Rothamsted’s omega-3 technology..

Yield10正在执行一项计划，使用工程化的Camelina商业化生产ω-3油和膳食产品，针对ω-3脂肪酸的水产饲料、宠物食品和营养市场。考虑到商业许可，Yield10预计将根据Rothamsted的omega-3技术的商业化支付一定的许可费、未来的里程碑付款和版税。。

Producing omega-3 fatty acids in engineered Camelina may represent a way to enable a predictable, land-based supply of high-quality omega-3 oils to meet the growing global demand for eicosapentaenoic acid (“EPA”) and docosahexaenoic acid (“DHA”). Currently, the primary source of EPA and DHA is ocean-caught fish, where omega-3 oil produced from anchovy harvest is the industry benchmark.

在工程骆驼草中生产ω-3脂肪酸可能是一种可以预测的、以陆地为基础的优质ω-3油供应的方式，以满足全球对二十碳五烯酸（“EPA”）和二十二碳六烯酸（“DHA”）日益增长的需求。目前，EPA和DHA的主要来源是海洋捕捞的鱼，从凤尾鱼收获中生产的ω-3油是行业基准。

Over the last few years, there has been increasing pressure on the supply of omega-3 oil due to over-fishing. The potential market opportunity for omega-3 fatty acids produced in Camelina includes use in pharmaceutical (ethyl-EPA) products, dietary supplements, and food and feed ingredients..

在过去几年中，由于过度捕捞，欧米茄-3石油的供应压力越来越大。Camelina生产的ω-3脂肪酸的潜在市场机会包括用于制药（乙基EPA）产品，膳食补充剂以及食品和饲料成分。。

“Over the last three years, the Yield10 team has provided us with expertise and support as our team has advanced the development of engineered Camelina from field testing to planting at multi-acre scale to produce omega-3 oil,” said Professor Angela Karp, Rothamsted director and chief executive officer.

“在过去的三年中，Yield10团队为我们提供了专业知识和支持，因为我们的团队推动了工程骆驼草的开发，从现场测试到多英亩规模的种植，以生产欧米茄-3油，”Rothamsted董事兼首席执行官Angela Karp教授说。

“Yield10’s innovations and capabilities in Camelina are impressive and successful commercialization of this technology could have significant benefits, offering sustainable production of an oil essential for nutrition and wellness to consumers, as well as providing crop diversification to growers. We look forward to the commercialization of omega-3 oil and meal products by Yield10 in the years ahead.”.

“Yield10在Camelina的创新和能力令人印象深刻，这项技术的成功商业化可能会产生巨大的好处，为消费者提供营养和健康所必需的油的可持续生产，并为种植者提供作物多样化。我们期待Yield10在未来几年将欧米茄-3油和膳食产品商业化。”。

“Enabled by the Rothamsted technology, we are on a promising path to commercializing elite omega-3 producing varieties of Camelina that combine good agronomics in the field while also producing high-value, high-purity omega-3 oils possessing very attractive economics,” said Oliver Peoples, Ph.D., President and Chief Executive Officer of Yield10 Bioscience.

Yield10 Bioscience总裁兼首席执行官Oliver Peoples博士说：“通过Rothamsted技术的支持，我们正在一条有前途的道路上将生产欧米茄-3的优质品种商业化，这些品种结合了该领域的良好农艺学，同时也生产出具有非常诱人经济效益的高价值，高纯度的欧米茄-3油。”。

“In 2024, we are positioned to execute on the scale-up of omega-3 producing Camelina and to submit key regulatory filings with the goal of being ready for an initial commercial launch into the oil and meal markets. We also look forward to improving the current Camelina varieties over time particularly with the deployment of herbicide tolerance and other performance traits.”.

“2024年，我们将扩大生产欧米茄-3的骆驼草的规模，并提交关键的监管文件，目的是为首次进入石油和膳食市场进行商业投放做好准备。我们还期待着随着时间的推移改进目前的骆驼草品种，特别是部署除草剂耐受性和其他性能特征。”。

In late 2020, Yield10 began a collaboration with Rothamsted to support Rothamsted’s Flagship Program to develop omega-3 oils in Camelina. The advanced technology developed by Rothamsted enables the sustainable, plant-based production of omega-3 nutritional oils in Camelina. Over the last decade, the Rothamsted team, led by Professor Johnathan Napier, Ph.D., Science Director, has demonstrated the production of omega-3 oils in Camelina seed and conducted evaluations of the oils in salmon feeding and human clinical studies to demonstrate lipid lowering effects..

2020年末，Yield10开始与Rothamsted合作，支持Rothamsted的旗舰计划，在Camelina开发ω-3油。Rothamsted开发的先进技术能够在骆驼草中以可持续的植物为基础生产ω-3营养油。在过去的十年中，由科学总监约翰·纳皮尔（JohnathanNapier）教授领导的罗瑟斯特德（Rothamsted）团队已经证明了骆驼籽中ω-3油的产生，并对鲑鱼喂养中的油进行了评估，并进行了人体临床研究，以证明其降脂作用。。

Recent Achievements in Yield10’s Omega-3 Camelina Program

Yield10 Omega-3 Camelina项目的最新成就

In the spring of 2024, Yield10 planted omega-3 (EPA and EPA+DHA) Camelina to scale up seed. Yield10 is also field testing for the first time herbicide tolerant omega-3 Camelina lines to guide selection of commercial quality lead and back-up lines.

2024年春天，Yield10种植了omega-3（EPA和EPA+DHA）骆驼草以扩大种子规模。Yield10也是首次对耐除草剂的omega-3骆驼草品系进行田间试验，以指导选择商业品质的铅和后备品系。

In the fall of 2023, Yield10 planted omega-3 (EPA) Camelina at the 50 acre-scale in Chile to produce oil for use in business development activities. The crop was harvested in early 2024.

2023年秋天，Yield10在智利种植了50英亩规模的omega-3（EPA）Camelina，生产用于商业发展活动的石油。该作物于2024年初收获。

In March of 2024, USDA-APHIS provided a positive response to the Company's announced filings for two requests for a Regulatory Status Review (“RSR”) with USDA-APHIS's Biotechnology Regulatory Services (BRS) under the SECURE Rule for proprietary elite Camelina varieties containing genes enabling the plant to produce the EPA and EPA+DHA components of omega-3 oil.

2024年3月，美国农业部-美国蚜虫研究所（USDA-APHIS）对该公司宣布的两项监管状态审查（“RSR”）申请做出了积极回应，该申请是美国农业部-美国蚜虫研究所（USDA-APHIS）的生物技术监管服务部（BRS）根据专有精英骆驼品种的安全规则提交的，该品种含有使该植物能够生产欧米茄-3油的EPA和EPA+DHA成分的基因。

Yield10 plans to conduct seed scale-up activities with omega-3 Camelina in 2024. Omega-3 fatty acids are used in aquafeed as well as for nutraceutical and pharmaceutical products..

Yield10计划在2024年与omega-3 Camelina进行种子扩大活动。ω-3脂肪酸用于水产饲料以及营养保健品和医药产品。。

In November of 2023, USDA-APHIS determined that Yield10’s glufosinate tolerant Camelina as well as its stacked herbicide tolerant Camelina may be planted and bred in the United States in response to two RSR packages submitted by Yield10.

2023年11月，美国农业部-美国蚜虫研究所（USDA-APHIS）根据Yield10提交的两份RSR文件包，确定Yield10的耐草铵膦骆驼草及其堆叠的耐除草剂骆驼草可以在美国种植和繁殖。

In October 2023, Yield10 announced it had signed a non-binding Letter of Intent (“LOI”) with BioMar Group, a global aquafeed producer, to form a partnership to commercialize Camelina engineered to produce omega-3 oil for use as a high-quality supplement to the scarce supply of marine long-chain fatty acids used in aquafeed.

2023年10月，Yield10宣布，它已与全球水产饲料生产商BioMar Group签署了一份不具约束力的意向书（“LOI”），以建立合作伙伴关系，将旨在生产ω-3油的Camelina商业化，以作为优质补充剂，补充水产饲料中稀缺的海洋长链脂肪酸供应。

The companies are working to develop a collaborative program to bring this new source of high-quality EPA and EPA+DHA omega-3 oils to the market..

两家公司正在努力开发一项合作计划，将这种优质EPA和EPA+DHAω-3油的新来源推向市场。。

About Rothamsted Research

关于Rothamsted Research

Rothamsted Research is the longest-running agricultural research institute in the world. We work from gene to field with a proud history of ground-breaking discoveries, from crop treatment to crop protection, from statistical interpretation to soils management. In 1843, our founders were the pioneers of modern agriculture, and we are known for our imaginative science and our collaborative influence on fresh thinking and farming practices.

罗森斯特德研究所是世界上运行时间最长的农业研究所。我们从基因到田间，从作物处理到作物保护，从统计解释到土壤管理，都有开创性发现的光荣历史。1843年，我们的创始人是现代农业的先驱，我们以富有想象力的科学以及对新思维和农业实践的合作影响而闻名。

Through independent science and innovation, Rothamsted has made significant contributions to improving agri-food systems in the UK and internationally. In terms of the institute’s economic contribution, the cumulative impact of our work in the UK was calculated to exceed £3000 million a year in 20151.

通过自主科学和创新，罗瑟斯特德为改善英国和国际农业食品系统做出了重大贡献。就研究所的经济贡献而言，据计算，2015年我们在英国工作的累积影响每年超过30亿英镑。

Rothamsted Research is strategically funded by the Biotechnology and Biological Sciences Research Council (BBSRC), with additional support from other national and international funding streams, and from industry. It is also supported by the Lawes Agricultural Trust (LAT)..

罗瑟斯特德研究由生物技术和生物科学研究委员会（BBSRC）提供战略资金，并得到其他国家和国际资金流以及行业的额外支持。它还得到了劳斯农业信托基金（LAT）的支持。。

For more information, visit the Rothamsted website or follow on X (formerly Twitter) @Rothamsted

有关更多信息，请访问Rothamsted网站或关注X（以前的Twitter）@Rothamsted

AboutYield10 Bioscience

关于IELD10生物科学

Yield10 Bioscience, Inc. ('Yield10' or the 'Company') is an agricultural bioscience company that is leveraging advanced genetics to develop the oilseed Camelina sativa ('Camelina') as a platform crop for large-scale production of sustainable seed products. These seed products include feedstock oils for renewable diesel and sustainable aviation biofuels; omega-3 (EPA and DHA+EPA) oils for pharmaceutical, nutraceutical and aquafeed applications; and, in the future, PHA bioplastics for use as biodegradable bioplastics.

Yield10 Bioscience，Inc.（“Yield10”或“公司”）是一家农业生物科学公司，该公司利用先进的遗传学技术开发油茶（Camelina sativa）（“Camelina”）作为大规模生产可持续种子产品的平台作物。这些种子产品包括可再生柴油和可持续航空生物燃料的原料油；用于制药、营养保健和水产饲料应用的omega-3（EPA和DHA+EPA）油；未来，PHA生物塑料将用作可生物降解的生物塑料。

Subject to the availability of sufficient financial resources to continue operations, our commercial plan is based on establishing a grain contracting business leveraging our proprietary elite Camelina seed varieties, focusing on the growing demand for low-carbon intensity feedstock oil for biofuels and omega-3 oils for nutritional applications.

在有足够的财政资源继续运营的情况下，我们的商业计划基于建立粮食承包业务，利用我们专有的精英骆驼种子品种，重点关注生物燃料低碳强度原料油和营养应用欧米茄-3油的需求增长。

Yield10 is headquartered in Woburn, MA and has a Canadian subsidiary, Yield10 Oilseeds Inc., located in Saskatoon, Canada..

Yield10总部位于马萨诸塞州沃本，并在加拿大萨斯卡通拥有一家加拿大子公司Yield10 Oilseeds Inc。。

For more information about the Company, please visit www.yield10bio.com, or follow the Company on X (formerly Twitter), Facebook and LinkedIn.

有关该公司的更多信息，请访问www.yield10bio.com，或在X（以前的Twitter）、Facebook和LinkedIn上关注该公司。

(YTEN-G)

（YTEN-G）

Safe Harbor forForward-LookingStatements

前瞻性声明的安全港

This press release contains forward-looking statements, which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The forward-looking statements in this release do not constitute guarantees of future performance.

本新闻稿包含前瞻性声明，这些声明是根据经修订的《1933年证券法》第27A节和经修订的《1934年证券交易法》第21E节的安全港规定做出的。本版本中的前瞻性声明不构成对未来业绩的保证。

Investors are cautioned that statements in this press release which are not strictly historical, including, without limitation, the development of EPA and EPA+DHA Camelina and the performance and production capacity of the omega-3 production technology, the potential for large-scale production of EPA8 Camelina, the future commercialization, potential market opportunity, economic viability and further development of the omega-3 varieties of Camelina and the omega-3 oils produced therefrom, and the potential for the omega-3 production technology to provide sustainable alternatives to existing means of omega-3 oil production, constitute forward-looking statements.

。

Such forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including, but not limited to, the Company’s ability to secure adequate funding in the near term to continue operations, as to which no assurance can be given, as well as the risks and uncertainties detailed in Yield10 Bioscience's filings with the Securities and Exchange Commission.

此类前瞻性陈述受到许多风险和不确定性的影响，这些风险和不确定性可能导致实际结果与预期结果存在重大差异，包括但不限于公司在短期内获得足够资金以继续运营的能力，对此无法提供保证，以及Yield10 Bioscience向证券交易委员会提交的文件中详述的风险和不确定性。

Yield10 assumes no obligation to update any forward-looking information contained in this press release or with respect to the matters described herein..

Yield10没有义务更新本新闻稿中包含的任何前瞻性信息或与本文所述事项有关的任何前瞻性信息。。

Contacts:

联系人：

Rothamsted Research:

罗瑟斯特德研究：

James Clarke, Head of Communications

+44 7964 832719, james.clarke@rothamsted.ac.uk

+44 7964 832719，james.clarke@rothamsted.ac.uk

Yield10 Bioscience:

Yield10生物科学：

Lynne H. Brum, (617) 682-4693, LBrum@yield10bio.com

林恩·H·布鲁姆，（617）682-4693，LBrum@yield10bio.com