We congratulate Liu et al.1 for publishing the article in the npj Digital Medicine, an insightful article that has captured our keen interest. By addressing the limitations of self-report questionnaires and utilizing accelerometer-measured data from a substantial cohort of 96,422 participants in the UK Biobank, the research unveils insightful patterns.

我们祝贺刘等人在npj数字医学杂志上发表了这篇文章，这篇有见地的文章引起了我们的浓厚兴趣。通过解决自我报告问卷的局限性，并利用来自英国生物库96422名参与者的大量加速度计测量数据，该研究揭示了有见地的模式。

The identified L-shaped association for light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA), along with the reversed L-shaped association for sedentary time, provides a nuanced understanding of PD risk. The consideration of exercise timing across different periods further enhances the comprehensive nature of the study.

确定的轻度体力活动（LPA）和中度至剧烈体力活动（MVPA）的L形关联，以及久坐时间的反向L形关联，提供了对PD风险的细微理解。考虑不同时期的锻炼时间进一步增强了研究的综合性。

The findings substantially advance our understanding in this area. However, we believe that incorporating additional factors could provide even more robust insights. We have two major suggestions for future research that could build upon the valuable contributions of this study.Firstly, sleep disorders should be considered.

这些发现大大提高了我们在这一领域的理解。但是，我们认为，纳入其他因素可以提供更有力的见解。我们对未来的研究提出了两个主要建议，可以基于这项研究的宝贵贡献。首先，应该考虑睡眠障碍。

Sleep issues are tightly correlated to PD2, and deterioration of sleep quality has been demonstrated as markers of the prodromal phase of PD3. Previous investigations have indicated that specific sleep characteristics were linked to the incidence of PD4,5,6. Intervention in the prodromal phase might either delay cellular degeneration or slow its rate of progression.

睡眠问题与PD2密切相关，睡眠质量的恶化已被证明是PD3前驱期的标志。先前的研究表明，特定的睡眠特征与PD4,5,6的发生率有关。前驱期的干预可能会延迟细胞变性或减缓其进展速度。

We noticed that this article did not consider the sleep issues. Whether physical activity could show a protective effect against PD in populations with the prodromal phase of PD remains unknown. Additional research is required to provide further evidence regarding the relationships between incident PD and objectively measured LPA and MVPA, especially within subgroups experiencing sleep-related issu.

我们注意到本文没有考虑睡眠问题。体育活动是否可以在PD前驱期人群中显示出对PD的保护作用尚不清楚。需要进一步的研究来提供有关事件PD与客观测量的LPA和MVPA之间关系的进一步证据，特别是在经历睡眠相关ISU的亚组中。

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Download referencesAuthor informationAuthors and AffiliationsInstitute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, ChinaLi-Hua Chen & Tong LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, ChinaLi-Hua Chen & Tong LiuAuthorsLi-Hua ChenView author publicationsYou can also search for this author in.

下载参考文献作者信息作者和附属机构南通大学疼痛医学与特殊环境医学研究所，南通，中国陈丽华和刘彤南通大学公共卫生学院营养与食品卫生系陈丽华和刘彤作者陈丽华查看作者出版物您也可以在中搜索这位作者。

PubMed Google ScholarTong LiuView author publicationsYou can also search for this author in

PubMed Google ScholarTong LiuView作者出版物您也可以在

PubMed Google ScholarContributionsL.-H.C. and T.L. conceived the idea of the manuscript. All authors drafted the manuscript. All authors approved the final version of the manuscript.Corresponding authorsCorrespondence to

PubMed谷歌学术贡献l-H、 C.和T.L.构思了手稿的想法。所有作者都起草了手稿。所有作者都批准了稿件的最终版本。通讯作者通讯

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陈丽华或刘彤。道德宣言

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Reprints and permissionsAbout this articleCite this articleChen, LH., Liu, T. Association of accelerometer-measured physical activity and incident Parkinson’s disease: insights and future research directions.

转载和许可本文引用本文Chen，LH。，Liu，T。加速度计测量身体活动和帕金森病事件协会：见解和未来研究方向。

npj Digit. Med. 7, 158 (2024). https://doi.org/10.1038/s41746-024-01154-0Download citationReceived: 21 February 2024Accepted: 31 May 2024Published: 18 June 2024DOI: https://doi.org/10.1038/s41746-024-01154-0Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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