SEATTLE--(BUSINESS WIRE)--NanoString Technologies (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, announced today the launch of the latest assay for the GeoMx® Digital Spatial Profiler (DSP). The GeoMx IO Proteome Atlas (IPA) is the industry’s most comprehensive spatial proteomics assay, enabling spatial profiling of more than 500 immuno-oncology (IO) relevant targets from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue sections..

西雅图-（商业线）-NanoString Technologies（纳斯达克股票代码：NSTG）是用于发现和转化研究的生命科学工具的领先供应商，今天宣布推出GeoMx®数字空间分析仪（DSP）的最新检测方法。GeoMx IO蛋白质组图谱（IPA）是业界最全面的空间蛋白质组学分析方法，可从FFPE（福尔马林固定，石蜡包埋）组织切片中对500多个免疫肿瘤学（IO）相关靶标进行空间分析。。

Containing IHC-compatible antibodies entirely from abcam’s extensive IO portfolio, the GeoMx IPA provides an extraordinary advancement in the field of spatial proteomics. The assay will provide researchers with more than five times the content of any competing panel, offering access to unprecedented power.

包含IHC兼容抗体完全来自abcam广泛的IO产品组合，GeoMx IPA在空间蛋白质组学领域提供了非凡的进步。该测定将为研究人员提供超过任何竞争小组内容的五倍，提供前所未有的权力。

Its utility is applicable to the search for novel biomarkers and drug targets, investigating therapeutic response, stratifying patients, and determining drug mechanisms of action..

它的实用性适用于寻找新的生物标志物和药物靶标，研究治疗反应，分层患者和确定药物作用机制。。

“The GeoMx IPA represents the convergence of two of the most dynamic fields in biomedical research: spatial biology and high-plex proteomics,” said Brad Gray, President and CEO of NanoString. “And with abcam providing the content, users get access to a broad range of high-quality recombinant IO antibodies in a single assay.

NanoString总裁兼首席执行官布拉德·格雷（Brad Gray）说：“GeoMx IPA代表了生物医学研究中两个最具活力的领域的融合：空间生物学和高复合蛋白质组学”。“并通过abcam提供的内容，用户可以在一次测定中获得广泛的高质量重组IO抗体。

When the IO Proteome Atlas is used in combination with our popular Whole Transcriptome Atlas (WTA), GeoMx DSP becomes by far the most powerful spatial profiler available.”.

当IO蛋白质组图谱与我们流行的全转录组图谱（WTA）结合使用时，GeoMx DSP成为迄今为止最强大的空间分析仪。

The combination of NanoString’s GeoMx IPA and WTA offers researchers unprecedented levels of data in the largest ever spatial proteomic panel of its kind. The panel leverages the unique capabilities of GeoMx DSP to non-destructively and quantitatively profile protein expression over five logs of dynamic range in distinct compartments such as the tumor, stroma, and immune contexture.

NanoString的GeoMx IPA和WTA的结合为研究人员提供了前所未有的最大规模的空间蛋白质组学数据。该小组利用GeoMx DSP的独特功能，在不同的区室（如肿瘤，基质和免疫环境）中，在动态范围的五个对数范围内非破坏性和定量地分析蛋白质表达。

Researchers can run GeoMx IPA as a standalone assay or in conjunction with GeoMx WTA and can even layer GeoMx IPA data with previously collected WTA data to easily analyze the two datasets..

研究人员可以运行GeoMx IPA作为独立的分析方法或与GeoMx WTA结合使用，甚至可以将GeoMx IPA数据与先前收集的WTA数据进行分层，以便于分析这两个数据集。。

“We are excited to partner with NanoString on this first-of-its-kind assay for high-plex spatial proteomics of FFPE,” said Alejandra Solache, SVP, R&D at abcam. “By contributing to the GeoMx IO Proteome Atlas we’re able to make abcam’s broad portfolio of precision antibodies for IO research available to researchers in a cutting-edge spatial biology product that will help enhance our understanding of cancer immunology and accelerate novel discoveries.”.

abcam的SVP研发部门Alejandra Solache说：“我们很高兴与NanoString合作开展FFPE高复合空间蛋白质组学的首次检测。“通过为GeoMx IO蛋白质组图谱做出贡献，我们能够为尖端空间生物学产品的研究人员提供abcam广泛的IO研究精确抗体组合，这将有助于增强我们对癌症免疫学的理解并加速新的发现。”。

The launch of the GeoMx IPA is the latest development in a long-standing collaboration between NanoString and abcam to provide high-quality, validated antibodies for use with NanoString’s spatial analysis platforms. Most recently, NanoString and abcam announced the inclusion of abcam-validated antibodies in the first 64-plex panel for NanoString’s CosMx™ Spatial Molecular Imager..

GeoMx IPA的推出是NanoString和abcam长期合作的最新发展，为NanoString的空间分析平台提供高质量，经过验证的抗体。最近，NanoString和abcam宣布在NanoString的CosMx的第一个64-plex面板中包含经过abcam验证的抗体™ 空间分子成像仪。。

Although the content is targeted for IO research, GeoMx IPA has broad applicability beyond cancer, including research areas such as infectious disease, organ transplant, autoimmunity, metabolism, and epigenetics.

虽然内容是针对IO研究的，但GeoMx IPA在癌症以外具有广泛的适用性，包括传染病，器官移植，自身免疫，新陈代谢和表观遗传学等研究领域。

The GeoMx IPA assay can enable researchers to:

GeoMx IPA分析可以使研究人员：

Spatially profile FFPE tissue using over 500 of abcam’s IHC-validated IO antibodies in a single assay, simplifying the search for new protein biomarkers and drug targets with unrivaled plex. Antibodies can also be used individually for further single target or lower plex investigation.

在单个测定中使用超过500种abcam的IHC验证的IO抗体在空间上描绘FFPE组织，简化了对具有无与伦比的plex的新蛋白质生物标志物和药物靶标的搜索。抗体也可以单独用于进一步的单靶或低plex研究。

Obtain more comprehensive biological information from precious tissue samples than traditional immunohistochemistry (IHC) or immunofluorescence (IF) assays.

与传统的免疫组织化学（IHC）或免疫荧光（IF）检测相比，从珍贵的组织样本中获得更全面的生物信息。

Discover novel IO drug targets by profiling the expression of over 500 protein targets from a single FFPE tissue section.

通过分析来自单个FFPE组织切片的超过500个蛋白质靶标的表达来发现新的IO药物靶标。

Profile the whole human transcriptome and IO proteome from a single slide by combining GeoMx IPA with GeoMx WTA for same-slide spatial proteogenomic analysis.

通过将GeoMx IPA与GeoMx WTA结合使用，从单个载玻片中分析整个人类转录组和IO蛋白质组，以进行相同的载玻片空间蛋白质组学分析。

The GeoMx IPA assay is available now for pre-order with shipments expected to begin in Q4 2023.

GeoMx IPA分析现在可以预先订购，预计将于2023年第四季度开始发货。

About NanoString Technologies, Inc.

关于NanoString Technologies，Inc。

NanoString Technologies, a leader in spatial biology, offers an ecosystem of innovative discovery and translational research solutions, empowering our customers to map the universe of biology. The GeoMx® Digital Spatial Profiler is a flexible and consistent solution combining the power of whole tissue imaging with gene expression and protein data for spatial whole transcriptomics and proteomics.

NanoString Technologies是空间生物学的领导者，提供创新发现和转化研究解决方案的生态系统，使我们的客户能够绘制生物学领域。GeoMx®数字空间分析仪是一种灵活而一致的解决方案，将全组织成像的功能与基因表达和蛋白质数据相结合，用于空间全转录组学和蛋白质组学。

The CosMx™ Spatial Molecular Imager is a single-cell imaging platform powered by spatial multiomics enabling researchers to map single cells in their native environments to extract deep biological insights and novel discoveries from one experiment. The AtoMx™ Spatial Informatics Platform is a cloud-based informatics solution with advanced analytics and global collaboration capabilities, enabling powerful spatial biology insights anytime, anywhere.

CosMx™ 空间分子成像仪是一个由空间多组学驱动的单细胞成像平台，使研究人员能够在其原生环境中绘制单个细胞，从一个实验中提取深刻的生物学见解和新发现。AtoMx™ 空间信息平台是基于云的信息学解决方案，具有先进的分析和全球协作功能，可在任何时间，任何地方提供强大的空间生物学见解。

At the foundation of our research tools is our nCounter® Analysis System, which offers a secure way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision. For more information, visit www.nanostring.com..

我们的研究工具的基础是我们的nCounter®分析系统，它提供了一种安全的方法，可以轻松地分析数百种基因，蛋白质，miRNA或拷贝数变异的表达，同时具有高灵敏度和高精度。欲了解更多信息，请访问www.nanostring.com。。

The NanoString logo, NanoString, NanoString Technologies, GeoMx, CosMx and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc., in the United States and/or other countries.

NanoString徽标，NanoString，NanoString Technologies，GeoMx，CosMx和nCounter是NanoString Technologies，Inc。在美国和/或其他国家/地区的商标或注册商标。