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Perturbations of the microbiota during neonatal and early life are associated with increased risk of severe upper respiratory viral infections. However, the ways in which the neonatal microbiota provides protection against infections remain unclear. In this preprint (not peer reviewed), Stevens et al.

新生儿和早期生命中微生物群的扰动与严重上呼吸道病毒感染的风险增加有关。。在这张预印本（未经同行评审）中，史蒂文斯等人。

explore a potential mechanism.In a mouse model of perinatal microbiota perturbation, dysbiotic or control neonatal mice were infected with influenza virus carrying the model antigen OVA. The authors found that dysbiotic pups mounted less-robust effector and memory antigen-specific CD8+ T cell responses in the lungs and had significantly greater infection-associated weight loss.

探索潜在的机制。在围产期微生物群扰动的小鼠模型中，益生菌或对照新生小鼠被携带模型抗原OVA的流感病毒感染。作者发现，益生菌幼崽在肺部产生的效应和记忆抗原特异性CD8+T细胞反应较弱，并且与感染相关的体重减轻明显更大。

Adoptive transfer and single-cell RNA-sequencing and spectral flow cytometry experiments indicated that CD8+ T cells from dysbiotic pups had intrinsic defects that precluded their licensing to effector and memory stages during infection with influenza virus. Gene-regulatory network analyses revealed Nfil3 as a novel regulator of lung CD8+ T cell fate remodelling.

过继转移和单细胞RNA测序以及光谱流式细胞术实验表明，来自益生菌幼崽的CD8+T细胞具有内在缺陷，这排除了它们在感染流感病毒期间进入效应和记忆阶段的许可。基因调控网络分析显示Nfil3是肺CD8+T细胞命运重塑的新型调节剂。

Expression of NFIL3 mRNA and protein was lower in lung CD8+ T cells from infected dysbiotic neonates than in those from infected control pups..

感染益生菌新生儿的肺CD8+T细胞中NFIL3 mRNA和蛋白的表达低于感染对照幼仔的肺CD8+T细胞。。

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ReferencesOriginal articleStevens, J. et al. Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Preprint at bioRxiv https://doi.org/10.1101/2024.04.09.588427 (2024)Related articleTsankov, B. K. Preprint Journal Club. PreprintClub https://www.preprintclub.com/preprint-reviews/2024-may-stevens (2024)Download referencesAuthor informationAuthors and AffiliationsPreprint Club, University of Toronto, Toronto, Ontario, CanadaBoyan K.

参考文献原始文章Stevens，J。等人。微生物群衍生的肌苷程序保护CD8+T细胞对新生儿流感的反应。bioRxiv预印本https://doi.org/10.1101/2024.04.09.588427（2024）相关文章桑科夫，B.K。预印本期刊俱乐部。预印本俱乐部https://www.preprintclub.com/preprint-reviews/2024-may-stevens。

Tsankov & Dana J. PhilpottAuthorsBoyan K. TsankovView author publicationsYou can also search for this author in.

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Dana J. Philpott.Rights and permissionsReprints and permissionsAbout this articleCite this articleTsankov, B.K., Philpott, D.J. Microbiota licenses protective CD8+ T cell responses against neonatal influenza.

达纳·J·菲尔波特。权利和许可打印和许可本文引用本文Sankov，B.K.，Philpott，D.J。微生物群许可针对新生儿流感的保护性CD8+T细胞应答。

Nat Rev Immunol (2024). https://doi.org/10.1038/s41577-024-01059-9Download citationPublished: 04 July 2024DOI: https://doi.org/10.1038/s41577-024-01059-9Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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