Nature：生物医学领域生物材料降解评估方法综述-动脉网

Nature：A review of biomaterial degradation assessment approaches employed in the biomedical field

Nature 等信源发布 2024-07-06 12:28

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AbstractThe biological response to biomaterials plays a crucial role in selecting suitable materials for the formulation and development of tissue engineering platforms. Biodegradation is one of the properties that is considered in selecting appropriate biomaterials for biomedical applications. Biodegradation is the process of breaking down large molecules into smaller molecules with/without the aid of catalytic enzymes.

摘要对生物材料的生物反应在选择合适的材料用于组织工程平台的制备和开发中起着至关重要的作用。生物降解是为生物医学应用选择合适的生物材料时考虑的特性之一。生物降解是在有/没有催化酶的帮助下将大分子分解成小分子的过程。

The biodegradation process is crucial in the chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) process of biomaterials and small molecules in the body. Degradation of biomaterials can be followed by assessing the physical, mechanical, and chemical attributes of biomaterials.

生物降解过程在体内生物材料和小分子的化学吸收，分布，代谢，排泄和毒性（ADMET）过程中至关重要。生物材料的降解可以通过评估生物材料的物理，机械和化学属性来完成。

There are several techniques/parameters that can be targeted when studying the degradation of biomaterials, with gravimetric analysis, surface erosion, and morphological changes being the largely employed techniques. However, the techniques present a few limitations, such as technical errors and material solubility being mistaken for degradation, and these techniques can infer but not confirm degradation as they do not provide the chemical composition of fragmenting/fragmented molecules.

在研究生物材料的降解时，可以针对几种技术/参数，其中重量分析，表面侵蚀和形态变化是主要使用的技术。然而，这些技术存在一些局限性，例如技术错误和材料溶解度被误认为降解，并且这些技术可以推断但不能确认降解，因为它们不提供碎片/碎片分子的化学组成。

The American Society for Testing and Materials (ASTM) guidelines provide techniques and parameters for assessing biodegradation. However, the ASTM guidelines for degradation assessment approaches and techniques need to be updated to provide sufficient evidence to draw conclusive decisions regarding the degradation of biomaterials.

美国材料与试验协会（ASTM）指南提供了评估生物降解的技术和参数。然而，需要更新ASTM降解评估方法和技术指南，以提供足够的证据，就生物材料的降解做出结论性决定。

In this review, the degradation assessment approaches and techniques are critically reviewed about their advantages and disadvantages, and to provide suggestions on how they can still play a role in assessing the degradation of biomaterials. Th.

在这篇综述中，对降解评估方法和技术的优缺点进行了批判性的回顾，并就它们如何在评估生物材料降解中发挥作用提出了建议。第。

IntroductionBiodegradation is the biological catalytic reaction of reducing complex macromolecules into smaller, less complex molecular structures (by-products)1. Biodegradable materials have been widely used in the biomedical field due to their tuneable nature. Biomaterials’ tunability includes, but is not limited to chemical, physical, mechanical, and biological functionalisation tailored for a wide range of applications in the biomedical field such as drug delivery, tissue engineering, and wound healing2,3,4.

简介生物降解是将复杂的大分子还原成较小，较不复杂的分子结构（副产物）的生物催化反应1。生物可降解材料由于其可调节性质而被广泛用于生物医学领域。生物材料的可调性包括但不限于化学，物理，机械和生物功能化，适用于生物医学领域的广泛应用，如药物输送，组织工程和伤口愈合2,3,4。

The processing of biomaterials allows for the development of solid and liquid-based formulations. Biomaterials in the biomedical field can be processed via a wide range of approaches to produce solid formulations such as polymeric sutures2, nanoparticles5,6, scaffolds7,8, and fibres9. The liquid-based biomaterial formulations include, but are not limited to hydrogels, gels, suspensions, and foam.

生物材料的加工允许开发基于固体和液体的制剂。生物医学领域的生物材料可以通过多种方法进行加工，以生产固体制剂，如聚合物缝合线2，纳米粒子5,6，支架7,8和纤维9。基于液体的生物材料制剂包括但不限于水凝胶，凝胶，悬浮液和泡沫。

The differences in biomaterial physical forms suggest that different degradation assessment approaches should be employed to assess the biomaterial degradation processes.The mechanism of degradation, the formed by-products, and the desirable properties of biomaterials are well-documented10,11,12,13.

生物材料物理形式的差异表明，应采用不同的降解评估方法来评估生物材料的降解过程。生物材料的降解机理，形成的副产物和理想的性能已有文献记载10,11,12,13。

However, in vitro, and in vivo assessment of biomaterial biodegradation approaches remain a matter of concern given that the approaches employed to evaluate biodegradation present several limitations. Conventional in vitro approaches for assessing the biodegradation of biomaterials include physical, chemical, and mechanical characterisation of biomaterials.

然而，生物材料生物降解方法的体外和体内评估仍然是一个令人担忧的问题，因为用于评估生物降解的方法存在一些局限性。用于评估生物材料生物降解的常规体外方法包括生物材料的物理，化学和机械表征。

Biomaterial degradation can occur via three interconnected processes, and it can be assessed by monitoring these processes namely physical, chemical, and mechanical changes. Biomaterials have characteristic functional gro.

生物材料降解可以通过三个相互关联的过程发生，并且可以通过监测这些过程（即物理，化学和机械变化）来评估。生物材料具有特征性的功能gro。

Code availability

代码可用性

No codes were generated or analysed during the current study.

在当前的研究中没有生成或分析代码。

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Download referencesAcknowledgementsThis work was supported by the National Research Foundation (NRF) of South Africa; the South African Medical Research Council (SAMRC); and the University of the Witwatersrand, Johannesburg.Author informationAuthors and AffiliationsWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South AfricaHillary Mndlovu, Pradeep Kumar, Lisa C.

下载参考文献致谢这项工作得到了南非国家研究基金会（NRF）的支持；南非医学研究委员会（SAMRC）；和约翰内斯堡威特沃特斯兰德大学。作者信息作者和附属机构威特沃特斯兰德大学健康科学学院药学与药理学系高级药物输送平台研究室，约翰内斯堡，7 York Road，Parktown，2193，南非希拉里·姆德洛夫，普拉迪普·库马尔，丽莎·C。

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PubMed Google ScholarContributionsHillary Mndlovu: writing—original draft, writing—review & editing. Pradeep Kumar: writing—review & editing, methodology, conceptualisation. Lisa C. du Toit: writing—review & editing. Yahya E. Choonara: writing—review & editing, funding acquisition, conceptualisation.Corresponding authorCorrespondence to.

PubMed Google ScholarContributionsHillary Mndlovu：撰写原稿，撰写评论和编辑。Pradeep Kumar：写作评论与编辑，方法论，概念化。丽莎·杜托伊特：写作评论与编辑。Yahya E.Choonara：写作评论和编辑，资金获取，概念化。对应作者对应。

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Reprints and permissionsAbout this articleCite this articleMndlovu, H., Kumar, P., du Toit, L.C. et al. A review of biomaterial degradation assessment approaches employed in the biomedical field.

转载和许可本文引用本文Mndlovu，H.，Kumar，P.，du Toit，L.C。等人对生物医学领域中使用的生物材料降解评估方法的回顾。

npj Mater Degrad 8, 66 (2024). https://doi.org/10.1038/s41529-024-00487-1Download citationReceived: 22 January 2024Accepted: 16 June 2024Published: 06 July 2024DOI: https://doi.org/10.1038/s41529-024-00487-1Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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