AbstractThe platelet/high-density lipoprotein ratio (PHR) has been identified as a significant indicator of inflammation and a hypercoagulable state, demonstrating a strong link with the severity of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). However, its correlation with hyperuricemia has not yet been documented.

摘要血小板/高密度脂蛋白比（PHR）已被确定为炎症和高凝状态的重要指标，与非酒精性脂肪性肝病（NAFLD）和代谢综合征（MetS）的严重程度密切相关。然而，它与高尿酸血症的相关性尚未被记录。

This study utilized a cross-sectional design, analyzing data collected from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016 in the United States. The platelet/high-density lipoprotein ratio (PHR) was determined by dividing the number of platelets (PLT) by the level of high-density lipoprotein cholesterol (HDL-C).

本研究采用横断面设计，分析了2007年至2016年美国国家健康与营养调查（NHANES）收集的数据。通过将血小板（PLT）的数量除以高密度脂蛋白胆固醇（HDL-C）的水平来确定血小板/高密度脂蛋白比（PHR）。

We employed multivariable logistic regression analyses, generalized additive models, and subgroup analyses to investigate the correlation between PHR and hyperuricemia. The study revealed a hyperuricemia prevalence of 18.56%. Analysis indicated a significant positive correlation between PHR and the risk of hyperuricemia (OR 1.11, 95% CI 1.08, 1.14).

我们采用多变量逻辑回归分析，广义加性模型和亚组分析来研究PHR与高尿酸血症之间的相关性。该研究显示高尿酸血症患病率为18.56%。分析表明，PHR与高尿酸血症风险之间存在显着的正相关（OR 1.11，95%CI 1.08，1.14）。

This correlation remained consistent across different subgroups including age, ethnicity, gender, and body mass index (BMI). Smooth curve fitting demonstrated a saturation effect between PHR and the risk of hyperuricemia. PHR is positively correlated with hyperuricemia and may serve as a novel biomarker for predicting the onset of this condition.

这种相关性在不同的亚组中保持一致，包括年龄，种族，性别和体重指数（BMI）。平滑曲线拟合显示PHR与高尿酸血症风险之间存在饱和效应。PHR与高尿酸血症呈正相关，可作为预测这种疾病发作的新型生物标志物。

Additionally, targeted interventions to improve PHR might help reduce the incidence of hyperuricemia..

此外，有针对性的干预措施以改善PHR可能有助于降低高尿酸血症的发生率。。

IntroductionSerum uric acid (SUA) represents the final product of purine breakdown in humans. Initially, purine is metabolized to hypoxanthine, which is then oxidized by xanthine dehydrogenase (XDH) to xanthine before further oxidation to uric acid (UA)1. Elevated levels of SUA can induce endothelial dysfunction, affecting vascular tone, thrombosis, inflammation, and oxidative stress2.

引言血清尿酸（SUA）代表人类嘌呤分解的最终产物。最初，嘌呤被代谢成次黄嘌呤，然后被黄嘌呤脱氢酶（XDH）氧化成黄嘌呤，然后进一步氧化成尿酸（UA）1。SUA水平升高可诱导内皮功能障碍，影响血管张力，血栓形成，炎症和氧化应激2。

High SUA levels can trigger gout and play a significant role in the development of cardiovascular diseases, including hypertension, atrial fibrillation, heart failure, and coronary artery disease. They are also closely associated with diabetes and metabolic syndrome (MetS)3,4,5,6,7,8. Despite a lack of extensive clinical study evidence, UA-lowering treatments have shown clinical significance in managing chronic kidney disease, blood sugar control, and cardiovascular outcomes9,10,11.

高SUA水平可引发痛风，并在心血管疾病的发展中发挥重要作用，包括高血压，心房颤动，心力衰竭和冠状动脉疾病。它们也与糖尿病和代谢综合征（MetS）3,4,5,6,7,8密切相关。尽管缺乏广泛的临床研究证据，但降尿酸治疗在管理慢性肾脏疾病，血糖控制和心血管结局方面显示出临床意义9,10,11。

In the United States, during 2015–2016, 47.1 million adults met the criteria for hyperuricemia, with a prevalence rate of 20.1%12. This condition and its associated comorbidities significantly increase the public health burden, highlighting the importance of early prediction, identification, and treatment of hyperuricemia.Hyperuricemia is closely associated with coagulation abnormalities.

在美国，2015-2016年期间，4710万成年人符合高尿酸血症的标准，患病率为20.1%12。这种情况及其相关的合并症显着增加了公共卫生负担，突出了高尿酸血症早期预测，鉴定和治疗的重要性。高尿酸血症与凝血异常密切相关。

SUA, through reactive oxygen species (ROS)-mediated oxidative stress, induces an inflammatory state and vascular damage, triggering thrombosis13. Platelets (PLT) serve a crucial function in the coagulation process, and several studies have demonstrated an independent correlation between PLT counts and the width of the PLT distribution representing the activation of PLT and with SUA14,15,16,17.

SUA通过活性氧（ROS）介导的氧化应激诱导炎症状态和血管损伤，引发血栓形成13。血小板（PLT）在凝血过程中起着至关重要的作用，一些研究表明PLT计数与代表PLT活化的PLT分布宽度和SUA14,15,16,17之间存在独立的相关性。

The lipid profile associated with hyperuricemia typically features reduced concentrations of high-density lipoprotein cholesterol (HDL.

与高尿酸血症相关的血脂特征通常是高密度脂蛋白胆固醇（HDL）浓度降低。

Data availability

数据可用性

This data can be found here: https://www.cdc.gov/nchs/nhanes.

这些数据可以在这里找到：https://www.cdc.gov/nchs/nhanes.

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Download referencesAuthor informationAuthors and AffiliationsDepartment of Cardio Surgery Intensive Care Unit, Ningbo Medical Centre Li Huili Hospital, Ningbo, ChinaLaisha Yan, Xiaoyan Hu, Shanshan Wu & Shunying ZhaoAuthorsLaisha YanView author publicationsYou can also search for this author in.

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PubMed Google ScholarXiaoyan HuView author publicationsYou can also search for this author in

PubMed Google ScholarXiaoyan HuView作者出版物您也可以在

PubMed Google ScholarShanshan WuView author publicationsYou can also search for this author in

PubMed Google Scholarshan WuView作者出版物您也可以在

PubMed Google ScholarShunying ZhaoView author publicationsYou can also search for this author in

PubMed Google ScholarShunying ZhaoView作者出版物您也可以在

PubMed Google ScholarContributionsSYZ was involved in the study design. XYH, LSY and SSW were involved in data analysis and graph preparation. LSY was responsible for writing and revising the manuscript. All authors reviewed the manuscript.Corresponding authorCorrespondence to.

PubMed Google ScholarContributionsSYZ参与了研究设计。XYH，LSY和SSW参与了数据分析和图形准备。LSY负责撰写和修改手稿。所有作者都审阅了手稿。对应作者对应。

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Reprints and permissionsAbout this articleCite this articleYan, L., Hu, X., Wu, S. et al. Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia.

转载和许可本文引用本文Yan，L.，Hu，X.，Wu，S。等人。血小板与高密度脂蛋白胆固醇比率与高尿酸血症的关系。

Sci Rep 14, 15641 (2024). https://doi.org/10.1038/s41598-024-66747-xDownload citationReceived: 21 March 2024Accepted: 03 July 2024Published: 08 July 2024DOI: https://doi.org/10.1038/s41598-024-66747-xShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

Sci Rep 1415641（2024）。https://doi.org/10.1038/s41598-024-66747-xDownload引文收到日期：2024年3月21日接受日期：2024年7月3日发布日期：2024年7月8日OI：https://doi.org/10.1038/s41598-024-66747-xShare本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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KeywordsPlateletCholesterolUric acidNHANES

关键词植物甾醇酸

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