AMSTERDAM, July 10, 2024 (GLOBE NEWSWIRE) -- This randomized, controlled trial was conducted at a tertiary IVF center, Ho Chi Minh City, Vietnam. Between January 2023 and June 2023, 120 women were randomized. Eligible women were aged 18–37 years with polycystic ovarian syndrome (PCOS). After providing written informed consent, participants were randomized (1:1) to undergo CAPA-IVM with or without FSH-priming.

阿姆斯特丹，2024年7月10日（环球通讯社）--这项随机对照试验在越南胡志明市的三级体外受精中心进行。在2023年1月至2023年6月期间，120名女性被随机分配。符合条件的女性年龄在18-37岁之间，患有多囊卵巢综合征（PCOS）。在提供书面知情同意后，参与者被随机（1:1）接受CAPA-IVM，有或没有FSH引发。

Participants in the FSH-priming group received two days of recombinant FSH (rFSH) injections before oocyte pick-up; no rFSH was given in the non-FSH group. All retrieved cumulus oocyte complexes underwent biphasic in vitro maturation (CAPA-IVM). Matured oocytes underwent fertilization through ICSI procedure, and were cultured to blastocyst stage followed by vitrification.

FSH启动组的参与者在取卵前接受了两天的重组FSH（rFSH）注射；非FSH组未给予rFSH。所有回收的卵丘-卵母细胞复合物均进行了双相体外成熟（CAPA-IVM）。成熟的卵母细胞通过ICSI程序进行受精，并培养至囊胚期，然后进行玻璃化冷冻。

Participants underwent a single blastocyst transfer during a frozen replacement cycle. The primary endpoint was the number of matured oocytes. The number of matured oocytes after CAPA-IVM did not differ significantly between the non-FSH and FSH groups (13 [9; 18] vs. 14 [7; 18]; absolute difference –1 [95% confidence interval –5, 4]).

参与者在冷冻替代周期中接受了单个胚泡转移。主要终点是成熟卵母细胞的数量。CAPA-IVM后成熟卵母细胞的数量在非FSH组和FSH组之间没有显着差异（13[9；18]比14[7；18]；绝对差异-1[95%置信区间-5,4]）。

There were also no significant between-group differences in other oocyte and embryology outcomes, including the number of cumulus-oocyte complexes, number of fertilized oocytes, total number of blastocysts and good blastocysts, and total number of frozen embryos. The live birth rate was 38.3% in the non-FSH group and 31.7% in the FSH group, with no statistically significant difference.

。非FSH组的活产率为38.3%，FSH组为31.7%，差异无统计学意义。

The miscarriage rate at <12 weeks’ gestation was 5.0% in both groups. Maternal complications were infrequent and occurred at a similar rate in the non-FSH and FSH groups; there were no preterm deliveries before 32 weeks’ gestation. The study results were presented by Dr. Tuong M Ho a.

两组妊娠<12周的流产率均为5.0%。非FSH组和FSH组的产妇并发症很少，发生率相似；妊娠32周前没有早产。研究结果由Tuong M Ho a博士介绍。