AbstractIntroductionNeonates in a NICU experience pain. Based on the cardiovascular and nociceptive systems link, a Newborn Infant Parasympathetic Evaluation (NIPE) monitor was designed to assess pain. The use of α2-agonists as analgesic-sedative drugs has increased in neonates. Given their effect on the autonomic system, we hypothesized that their use may alter NIPE’s measurement capacity.MethodsData were prospectively collected.

摘要简介新生儿重症监护病房的新生儿会感到疼痛。基于心血管和伤害感受系统的联系，设计了一种新生儿副交感神经评估（NIPE）监护仪来评估疼痛。新生儿中使用α2激动剂作为镇痛镇静药物的情况有所增加。鉴于它们对自主系统的影响，我们假设它们的使用可能会改变NIPE的测量能力。方法前瞻性收集数据。

The included patients were evaluated using combined pain assessment systems.ResultsSixteen newborns requiring sedoanalgesia underwent a total of 84 pain assessments. A good correlation was found between the NIPE-index and the COMFORT-neo and the crSO2 (cerebral regional oxygen saturation). No correlation was found in premature infants.

纳入的患者使用联合疼痛评估系统进行评估。结果16名需要sedoanalgesia的新生儿共接受了84次疼痛评估。NIPE指数与舒适度neo和crSO2（脑区域氧饱和度）之间存在良好的相关性。早产儿没有发现相关性。

By sedation group, the correlation remained in those receiving α2-agonist.ConclusionNIPE is a reliable tool for pain assessment. Further studies in premature infants are needed. The use of α2-agonist does not alter the measuring capacity of NIPE. The correlation between NIPE-index and crSO2 was also demonstrated..

通过镇静组，接受α2-激动剂的患者仍然存在相关性。结论NIPE是一种可靠的疼痛评估工具。需要对早产儿进行进一步的研究。α2-激动剂的使用不会改变NIPE的测量能力。还证明了NIPE指数与crSO2之间的相关性。。

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Fig. 1: NIPEm and pain assessment correlation.Fig. 2: NIPEm and pain related variables correlation.Fig. 3: NIPEm and Comfort-neo correlation by pathology.

图1:NIPEm和疼痛评估的相关性。图2:NIPEm与疼痛相关变量的相关性。图3:NIPEm和Comfort-neo病理相关性。

Data availability

数据可用性

All data generated or analyzed during this study are included in this article and its supplementary material files. Further enquiries can be directed to the corresponding author.

本研究期间生成或分析的所有数据均包含在本文及其补充材料文件中。进一步的询问可以直接联系通讯作者。

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Download referencesAuthor informationAuthors and AffiliationsNeonatology, BCNatal, Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Déu and Hospital Clinic, University of Barcelona, Barcelona, SpainCatarina Sevivas, Ruth Ibáñez, Melissa Fontalvo & Marta Camprubí-CamprubíNeonatology, Clinical University Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), RICORS, Santiago de Compostela, SpainCatarina SevivasNeonatology, Clinical University Hospital of Santiago de Compostela, CIBERER, Health Research Institute of Santiago de Compostela (IDIS), RICORS, MetabERN: European Reference Network for Rare Hereditary Metabolic Disorders, Santiago de Compostela, SpainMaría Luz CouceCardiovascular Research Group, Sant Joan de Déu Research Institute, Barcelona, SpainMarta Camprubí-CamprubíAuthorsCatarina SevivasView author publicationsYou can also search for this author in.

下载参考文献作者信息作者和所属机构内科医生，BCNatal，巴塞罗那母婴医学中心，圣琼·德杜医院和巴塞罗那大学医院诊所，巴塞罗那，斯潘卡塔琳娜·塞维瓦斯，露丝·伊巴涅斯，梅丽莎·丰塔尔沃和玛塔·坎普鲁比-坎普鲁比新生儿学，圣地亚哥德孔波斯特拉临床大学医院，圣地亚哥德孔波斯特拉健康研究所（IDIS），里科，圣地亚哥德孔波斯特拉，斯潘卡塔琳娜·塞维瓦斯新生儿学，圣地亚哥德孔波斯特拉临床大学医院，西贝雷圣地亚哥·德孔波斯特拉健康研究所（IDIS），里科尔斯，梅塔伯恩：欧洲罕见遗传性代谢紊乱参考网络，圣地亚哥·德孔波斯特拉，斯宾玛·卢兹·库塞卡心血管研究小组，圣琼·德杜研究所，巴塞罗纳，斯宾玛塔坎普鲁比-坎普鲁比作者卡塔琳娜·塞维瓦斯观点作者出版物你也可以在中搜索这位作者。

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PubMed Google ScholarContributionsCS conceptualization, data acquisition, writing manuscript and revising the article for important intellectual content; RI, MF conceptualization and data acquisition; MLC conceptualization and revising the article; MCC development data acquisition tool; data analysis; and revising the article for important intellectual content.

PubMed谷歌学术贡献SCS概念化，数据采集，撰写稿件并修改重要知识内容的文章；RI，MF概念化和数据采集；MLC概念化和修改文章；；数据分析；并修改文章的重要知识内容。

All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.Corresponding authorCorrespondence to.

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Catarina Sevivas.Ethics declarations

卡塔琳娜·塞维瓦斯。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

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Ethics approval

道德认可

This study protocol was reviewed and approved by the local the Ethics Committee of the Sant Joan de Deú Research Foundation with de I.C. EOM-01-22 approval code and was conducted according to the Declaration of Helsinki. Written parental informed consent was obtained prior to study enrollment. Patients were recruited between April 2022 and August 2022..

该研究方案已由Sant Joan deúResearch Foundation当地伦理委员会审查和批准，并符合de I.C.EOM-01-22批准代码，并根据赫尔辛基宣言进行。在研究登记之前获得了父母的书面知情同意书。患者于2022年4月至2022年8月期间招募。。

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。权利和许可Pringer Nature或其许可人（例如协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有专有权；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Sivas，C.，Ibáñez，R.，Fontalvo，M。

et al. Pain and heart rate variability in neonates receiving dexmedetomidine..

等。接受右美托咪定治疗的新生儿的疼痛和心率变异性。。

J Perinatol (2024). https://doi.org/10.1038/s41372-024-02053-8Download citationReceived: 22 February 2024Revised: 28 June 2024Accepted: 08 July 2024Published: 20 July 2024DOI: https://doi.org/10.1038/s41372-024-02053-8Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

J Perinatol（2024）。https://doi.org/10.1038/s41372-024-02053-8Download引文收到日期：2024年2月22日修订日期：2024年6月28日接受日期：2024年7月8日发布日期：2024年7月20日OI：https://doi.org/10.1038/s41372-024-02053-8Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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