WEDNESDAY, July 31, 2024 -- The amyloid probability score 2 (APS2) has high diagnostic accuracy for identifying Alzheimer disease (AD) among individuals with cognitive symptoms in primary and secondary care, according to a study published online July 28 in the Journal of the American Medical Association to coincide with the Alzheimer's Association International Conference, held from July 28 to Aug.

2024年7月31日，星期三——根据7月28日在美国医学会杂志（Journal of The American Medical Association）上在线发表的一项研究，淀粉样蛋白概率评分2（APS2）对于在初级和二级保健中有认知症状的个体中识别阿尔茨海默病（AD）具有很高的诊断准确性，以配合7月28日至8月举行的阿尔茨海默病协会国际会议。

1 in Philadelphia.Sebastian Palmqvist, M.D., Ph.D., from Lund University in Sweden, and colleagues prospectively evaluated a clinically available AD blood test in primary and secondary care using predefined biomarker cutoff values among 1,213 patients undergoing clinical evaluation due to cognitive symptoms.

费城排名第一。瑞典隆德大学医学博士塞巴斯蒂安·帕尔姆奎斯特（SebastianPalmqvist）及其同事使用预定义的生物标志物临界值，对1213名因认知症状接受临床评估的患者进行了前瞻性评估，以评估初级和二级保健中临床可用的AD血液检测。

The biomarker cutoff values were applied to primary and secondary care cohorts (307 and 200 patients, respectively); the blood test was then evaluated prospectively in the primary and secondary care cohorts (208 and 398 patients, respectively). The ratio of plasma phosphorylated tau 217 (p-tau217) to non-p-tau217 (expressed as percentage of p-tau217) alone and when combined with the amyloid-β 42 and amyloid-β 40 (Aβ42:Aβ40) plasma ratio (APS2) was determined.The researchers found that 50 percent of patients had AD pathology in the primary and secondary care assessments.

；然后在初级和二级保健队列（分别为208名和398名患者）中对血液检查进行前瞻性评估。测定血浆磷酸化tau 217（p-tau217）与非p-tau217（以p-tau217的百分比表示）的比率，以及与淀粉样蛋白-β42和淀粉样蛋白-β40（Aβ42:Aβ40）血浆比率（APS2）。研究人员发现，在初级和二级保健评估中，50%的患者患有AD病理。

High diagnostic accuracy was seen in all four cohorts (primary and secondary care cohorts and prospective primary and secondary care cohorts; range, 88 to 92 percent). Diagnostic accuracy for identifying clinical AD was 61 percent for primary care physicians after clinical examination, cognitive testing, and a computed tomographic scan and 73 percent for dementia specialists compared with 91 percent using the APS2.

在所有四个队列（初级和二级保健队列以及预期的初级和二级保健队列；范围为88%至92%）中，诊断准确性都很高。在临床检查、认知测试和计算机断层扫描后，初级保健医生识别临床AD的诊断准确率为61%，痴呆专家的诊断准确率为73%，而使用APS2的诊断准确率为91%。

The diagnostic accuracy in the overall population using APS2 did not differ from that using.

使用APS2的总体人群的诊断准确性与使用APS2的人群没有差异。