AbstractBoxazomycins A-C are potent broad-spectrum antibiotics isolated from Actinomycetes strain G495-1 in 1987. We now report that boxazomycin A inhibits bacterial growth by selectively inhibiting protein synthesis, its effect is bacteriostatic, and it is equally active against drug resistant bacterial strains.

摘要Boxazomycins A-C是1987年从放线菌G495-1菌株中分离出的有效广谱抗生素。我们现在报道，boxazomycin A通过选择性抑制蛋白质合成来抑制细菌生长，其作用是抑菌的，并且对耐药菌株具有同等活性。

No cross-resistance to protein synthesis inhibitors was observed suggesting that its inhibition is distinct from clinical protein synthesis inhibitors. We also report in vivo efficacy in a Staphylococcus aureus murine infection model supported by corresponding pharmacokinetic studies..

未观察到对蛋白质合成抑制剂的交叉耐药性，表明其抑制作用不同于临床蛋白质合成抑制剂。我们还报告了相应的药代动力学研究支持的金黄色葡萄球菌鼠感染模型的体内疗效。。

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图1图。图2。3图。。5

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Download referencesAuthor informationAuthor notesSheo B. SinghPresent address: Charles A Dana Research Institute of Scientist Emeriti, Drew University, Madison, NJ, 07054, USASheo B. SinghPresent address: Department of chemistry & Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, 07030, USAJames OcciPresent address: Center for Vector Biology, Rutgers University, New Brunswick, NJ, 08901, USADeceased: John OndeykaDeceased: John F.

下载参考文献作者信息作者注释Sheo B.SinghPresent地址：Charles A Dana Research Institute of Scientist Emeriti，Drew University，Madison，NJ，07054，USASheo B.SinghPresent地址：美国新泽西州霍博肯史蒂文斯理工学院化学与化学生物学系，07030，USAJames Occpresent地址：罗格斯大学矢量生物学中心，新泽西州新不伦瑞克，08901，USA死者：John Ondeykadestopped：John F。

BarrettDeceased: Prakash MasurekarAuthors and AffiliationsMerck & Co. Inc., Rahway, NJ, 07065, USASheo B. Singh, James Occi, John Ondeyka, John F. Barrett, Prakash Masurekar, Mary Motyl, Charles Gill & Gino SalituroAuthorsSheo B. SinghView author publicationsYou can also search for this author in.

巴雷特已故：Prakash MasurekaAuthors and AffiliationsMerck＆Co.Inc.，新泽西州拉赫韦，07065，USASheo B.Singh，James Occi，John Ondeyka，John F.Barrett，Prakash Masurekar，Mary Motyl，Charles Gill＆Gino Saliturauthoussheo B.SinghView作者出版物您也可以在中搜索这位作者。

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All authors were employed by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA where this work was conducted.

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et al. Antibacterial and mechanism of action studies of boxazomycin A..

boxazomycin A的抗菌作用和作用机制研究。。

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