AbstractObjectiveWe investigated the trends of blood absolute monocyte count (AMC) over 72 h after suspecting necrotizing enterocolitis (NEC).Study designA single center, retrospective study, the AMC was plotted over 72 h after NEC evaluation. Receiver operating characteristic (ROC) curve analysis assessed change in AMC to identify absence of NEC and different NEC stages.ResultsIn 130 infants, the AMC decreased in patients with NEC stage 2 or 3.

摘要目的我们调查了怀疑坏死性小肠结肠炎（NEC）后72小时内血液绝对单核细胞计数（AMC）的趋势。研究设计一项单中心回顾性研究，在NEC评估后72小时绘制AMC。受试者工作特征（ROC）曲线分析评估了AMC的变化，以确定是否存在NEC和不同的NEC阶段。结果130例NEC 2、3期患儿AMC下降。

Stages 2 and 3 NEC experienced a drop in AMC compared to an increase in no NEC, possible NEC, or positive culture (p < 0.05). AMC increase 24% or less can differentiate NEC stage 2/3 from possible NEC with an area under the curve (AUC) of 0.78. While decrease of more than 32% can differentiate stage 2/3 vs.

与无NEC，可能的NEC或阳性培养物的增加相比，第2阶段和第3阶段NEC的AMC下降（p<0.05）。AMC增加24%或更少可以将NEC阶段2/3与可能的NEC区分开来，曲线下面积（AUC）为0.78。而减少超过32%可以区分2/3阶段与。

possible or no NEC with AUC of 0.71.Discussion/ConclusionsA decrease in AMC can be an adjunct biomarker to confirm the diagnosis of NEC..

可能或无NEC，AUC为0.71。讨论/结论AMC的降低可以作为确认NEC诊断的辅助生物标志物。。

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Fig. 1: Evaluation of average AMC across time.Fig. 2: Change in AMC from baseline to illness onset.Fig. 3: ROC curve analyses to assess validity of percentage change in AMC from baseline to NEC suspicion.

图1：评估平均AMC随时间的变化。图2:AMC从基线到疾病发作的变化。图3:ROC曲线分析评估AMC从基线到NEC怀疑的百分比变化的有效性。

Data availability

数据可用性

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

在当前研究期间生成和/或分析的数据集可根据合理要求从通讯作者处获得。

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Download referencesAuthor informationAuthors and AffiliationsDivision of Neonatology, CHOC Children’s, Orange, CA, USAMeghan Moroze, Grant Shafer & Michel MikhaelCHOC Children’s Research Institute, Orange, CA, USATricia Morphew & Lois W. SayrsDivision of Radiology, CHOC Children’s, Orange, CA, USAAzam Eghbal & W.

下载参考文献作者信息作者和附属机构新生儿科，加利福尼亚州奥兰治市CHOC儿童医院，USAMeghan Moroze，Grant Shafer＆Michel MikhaelCHOC儿童研究所，加利福尼亚州奥兰治市，USATricia Morphew＆Lois W.Sayrs放射科，加利福尼亚州奥兰治市CHOC儿童医院，USAAzam Eghbal＆W。

Nathan HolmesUniversity of California Irvine, School of Medicine, Irvine, CA, USAGrant Shafer & Michel MikhaelAuthorsMeghan MorozeView author publicationsYou can also search for this author in.

内森·霍姆斯加州大学欧文分校医学院，加利福尼亚州欧文市，USAGrant Shafer＆Michel MikhaelAuthorsMeghan MorozeView作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsDrs. Moroze, Shafer, and Mikhael contributed to the conceptualization and design of the study, the collection, analysis, and interpretation of the data. They drafted the initial manuscript and approved the final manuscript as submitted. Mrs. Morphew and Dr.

PubMed谷歌学术贡献SDRS。Moroze，Shafer和Mikhael为研究的概念化和设计，数据的收集，分析和解释做出了贡献。他们起草了初稿，并批准了提交的最终稿件。Morfew女士和Dr。

Sayrs contributed to the analysis and interpretation of the data. They contributed to all drafts of the manuscript and approved the final manuscript as submitted. Drs. Eghbal and Holmes contributed to the collection, analysis, and interpretation of the data. They contributed to all drafts of the manuscript and approved the final manuscript as submitted.Corresponding authorCorrespondence to.

Sayrs为数据的分析和解释做出了贡献。他们为稿件的所有草稿做出了贡献，并批准了提交的最终稿件。Eghbal博士和Holmes博士为数据的收集，分析和解释做出了贡献。他们为稿件的所有草稿做出了贡献，并批准了提交的最终稿件。对应作者对应。

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Competing interests

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The authors declare no competing interests.

作者声明没有利益冲突。

Ethics approval and consent to participate

道德批准和同意参与

The study protocol was reviewed and approved by Children’s Hospital of Orange County IRB Committee, IRB ID 1919772-1 internal number 200574. No ethics approval was needed. This study was granted by the Children’s Hospital of Orange County IRB, an exemption from written informed consent given the retrospective nature of the study..

。不需要道德批准。这项研究是由奥兰治县IRB儿童医院批准的，鉴于研究的回顾性，这是一项书面知情同意书的豁免。。

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et al. Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?..

疑似坏死性小肠结肠炎早产儿的血液绝对单核细胞计数趋势：诊断的辅助工具？。。

J Perinatol (2024). https://doi.org/10.1038/s41372-024-02070-7Download citationReceived: 07 December 2023Revised: 09 July 2024Accepted: 17 July 2024Published: 01 August 2024DOI: https://doi.org/10.1038/s41372-024-02070-7Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

J Perinatol（2024）。https://doi.org/10.1038/s41372-024-02070-7Download引文接收日期：2023年12月7日修订日期：2024年7月9日接受日期：2024年7月17日发布日期：2024年8月1日OI：https://doi.org/10.1038/s41372-024-02070-7Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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