AbstractTNFAIP8 family molecules have been recognized for their involvement in the progression of tumors across a range of cancer types. Emerging experimental data suggests a role for certain TNFAIP8 family molecules in the development of glioma. Nonetheless, the comprehensive understanding of the genomic alterations, prognostic significance, and immunological profiles of TNFAIP8 family molecules in glioma remains incomplete.

摘要TNFAIP8家族分子因其参与多种癌症类型的肿瘤进展而被认可。新出现的实验数据表明某些TNFAIP8家族分子在神经胶质瘤的发展中起作用。尽管如此，对胶质瘤中TNFAIP8家族分子的基因组改变，预后意义和免疫学特征的全面了解仍然不完整。

In the study, using the comprehensive bioinformatics tools, we explored the unique functions of 4 TNFAIP8 members including TNFAIP8, TNFAIP8L1, TNFAIP8L2 and TNFAIP8L3 in glioma. The expressions of TNFAIP8, TNFAIP8L1, TNFAIP8L2, and TNFAIP8L3 were notably upregulated in glioma tissues compared to normal tissues.

在这项研究中，我们使用全面的生物信息学工具，探索了包括TNFAIP8，TNFAIP8L1，TNFAIP8L2和TNFAIP8L3在内的4个TNFAIP8成员在胶质瘤中的独特功能。。

Furthermore, survival analysis indicated that elevated expression levels of TNFAIP8, TNFAIP8L1 and TNFAIP8L2 were correlated with unfavorable outcomes in terms of overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) among glioma patients. Genetic modifications, such as mutations and copy number alterations, within the TNFAIP8 family exhibited a significant association with extended OS, DSS and PFS in individuals diagnosed with glioma.

此外，生存分析表明，在胶质瘤患者中，TNFAIP8，TNFAIP8L1和TNFAIP8L2的表达水平升高与总生存期（OS），疾病特异性生存期（DSS）和无进展期（PFI）的不利结果相关。TNFAIP8家族中的遗传修饰，例如突变和拷贝数改变，与诊断为神经胶质瘤的个体的扩展OS，DSS和PFS显着相关。

The findings suggest a noteworthy correlation between TNFAIP8 family members and the age and 1p/19q codeletion status of glioma patients. We also found that there were significant relationships between TNFAIP8 family expression and tumor immunity in glioma. Furthermore, functional annotation of TNFAIP8 family members and their co-expressed genes in gliomas was carried out using GO and KEGG pathway analysis.

研究结果表明，TNFAIP8家族成员与胶质瘤患者的年龄和1p/19q密码状态之间存在值得注意的相关性。我们还发现TNFAIP8家族表达与胶质瘤中的肿瘤免疫之间存在显着关系。此外，使用GO和KEGG途径分析对神经胶质瘤中TNFAIP8家族成员及其共表达基因进行功能注释。

The GO analysis revealed that the primary biological processes influenced by the TNFAIP8 family co-expressed genes included cell chemotaxis, temperature homeostasis, a.

GO分析显示，受TNFAIP8家族共表达基因影响的主要生物学过程包括细胞趋化性，温度稳态，a。

IntroductionGlioma, a prevalent and aggressive primary tumor of the central nervous system, primarily consists of glial cells such as astrocytoma, oligodendroglioma, ependyma, anaplastic astrocytoma, and glioblastoma1. Low-grade glioma (LGG), encompassing WHO Grade II and III tumors, exhibit a less severe clinical course compared to high-grade glioma, with patients experiencing a survival period ranging from 1 to 15 years2.

引言神经胶质瘤是中枢神经系统的一种普遍且侵袭性的原发性肿瘤，主要由胶质细胞组成，如星形细胞瘤，少突胶质细胞瘤，室管膜，间变性星形细胞瘤和胶质母细胞瘤1。与高级别胶质瘤相比，包括WHO II级和III级肿瘤在内的低级别胶质瘤（LGG）的临床病程较轻，患者的生存期为1至15年2。

Glioblastoma (GBM) represents a predominant high-grade subtype, comprising 54% of glioma in the United States3. The median survival rate for patients diagnosed with GBM at the outset is less than 15 months, despite undergoing optimal surgical resection followed by chemoradiotherapy. Overall, the prognosis of glioma patients remains challenging to ascertain, even with the comprehensive utilization of surgery, radiotherapy, and chemotherapy.

。尽管进行了最佳的手术切除和放化疗，但一开始被诊断为GBM的患者的中位生存率不到15个月。总体而言，即使综合利用手术，放疗和化疗，胶质瘤患者的预后仍然难以确定。

Numerous studies have demonstrated interobserver variations in the pathological grading diagnosis of glioma based solely on histological discrepancies4,5. In response to this, the 2016 revision of the WHO Classification of Central Nervous System Tumors incorporated molecular parameters, which have been increasingly shown to have a stronger correlation with clinical outcomes compared to traditional histological classification6.

许多研究表明，仅基于组织学差异，神经胶质瘤病理分级诊断的观察者间差异4,5。为此，2016年修订的WHO中枢神经系统肿瘤分类纳入了分子参数，与传统的组织学分类相比，分子参数与临床结果的相关性越来越强6。

In recent studies, a multitude of cancer-related genes have been discovered to exert a substantial influence on the onset and progression of glioma. Thus, the exploration of novel biomarkers exhibiting high specificity and sensitivity, along with the identification of new molecular targets, will aid in elucidating the molecular mechanisms underlying glioma and enhancing the prognosis of glioma patients.The TNFAIP8 (tumor necrosis factor-α-induced protein 8; TNFAIP8) family, comprised of TNFAI.

在最近的研究中，已经发现许多与癌症相关的基因对神经胶质瘤的发生和发展产生重大影响。因此，探索具有高特异性和敏感性的新型生物标志物，以及鉴定新的分子靶标，将有助于阐明神经胶质瘤的分子机制并改善神经胶质瘤患者的预后。TNFAIP8（肿瘤坏死因子-α诱导蛋白8；TNFAIP8）家族，由TNFAI组成。

Data availability

数据可用性

Research data are shown in the supplements files.

研究数据显示在补充文件中。

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Download referencesAuthor informationAuthor notesThese authors contributed equally: Xuezhong Zhang and Xuebin Zhang.Authors and AffiliationsDepartment of Laboratory Medicine, Zibo Central Hospital, Zibo, Shandong, ChinaXuezhong ZhangDepartment of Anorectal Surgery, Dongying People’s Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, ChinaXuebin ZhangDepartment of Infectious Diseases, Binzhou Medical University Hospital, Binzhou, 256603, Shandong, ChinaTonggang LiuBinzhou Medical University School of Nursing, Binzhou, 256603, Shandong, ChinaKaihui ShaAuthorsXuezhong ZhangView author publicationsYou can also search for this author in.

下载参考文献作者信息作者注意到这些作者做出了同样的贡献：张学忠和张学斌。作者和所属单位山东省淄博市淄博市中心医院检验科张学忠东营市人民医院（山东省医院集团东营医院）肛肠外科张学斌山东省东营市滨州医科大学医院传染病科，山东省滨州市256603，中国通港柳滨州医科大学护理学院，山东省滨州市256603，中国开惠市作者张学忠观点作者出版物您也可以在中搜索这位作者。

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PubMed Google ScholarContributionsX.Z. and T.L. proposed the study idea. X.Z., X.Z., T.L. and K.S. collected and analyzed the data. X.Z. drafted the manuscript. X.Z. and K.S. critically revised the manuscript. All authors contributed to the article and approved the submitted version.Corresponding authorsCorrespondence to.

PubMed谷歌学术贡献x。Z、 T.L.提出了研究思路。十、 Z.，X.Z.，T.L.和K.S.收集并分析了数据。十、 Z.起草了手稿。十、 Z.和K.S.批判性地修改了手稿。。通讯作者通讯。

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Reprints and permissionsAbout this articleCite this articleZhang, X., Zhang, X., Liu, T. et al. Comprehensive analysis of the prognostic and immunological signature of TNFAIP8 family genes in human glioma.

转载和许可本文引用本文Zhang，X.，Zhang，X.，Liu，T。等人对人脑胶质瘤中TNFAIP8家族基因的预后和免疫特征的综合分析。

Sci Rep 14, 17875 (2024). https://doi.org/10.1038/s41598-024-68784-yDownload citationReceived: 08 April 2024Accepted: 29 July 2024Published: 02 August 2024DOI: https://doi.org/10.1038/s41598-024-68784-yShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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KeywordsTNFAIP8 familyPrognosticImmunological signatureGlioma

关键词NFAIP8家族预后免疫信号胶质瘤

Subjects

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BiomarkersCancerOncology

生物标志物

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