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A new study suggests that glial cells in both Huntington disease (HD) and schizophrenia share abnormal gene transcription patterns. RNA sequencing of glial progenitor cells derived from human pluripotent stem cells revealed preserved gene sets between the diseases that were distinct from healthy control donors.

一项新的研究表明，亨廷顿舞蹈病（HD）和精神分裂症中的神经胶质细胞都具有异常的基因转录模式。来自人多能干细胞的神经胶质祖细胞的RNA测序揭示了与健康对照供体不同的疾病之间保留的基因组。

A large proportion of genes that were supressed in both diseases are involved in synaptic signalling, including OLIG2, TCF7L2 and ADGRL3, which regulate glutamate signalling. The results indicate that supressed glial receptivity to glutamate could contribute to pathology in both HD and schizophrenia..

在这两种疾病中被抑制的大部分基因都参与突触信号传导，包括调节谷氨酸信号传导的OLIG2，TCF7L2和ADGRL3。结果表明，抑制胶质细胞对谷氨酸的接受性可能有助于HD和精神分裂症的病理学。。

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ReferencesOriginal articleHuynh, N. P. T. et al. Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia. Brain https://doi.org/10.1093/brain/awae166 (2024)Download referencesAuthor informationAuthors and AffiliationsNature Reviews Neurology http://www.nature.com/nrneurol/Lisa KianiAuthorsLisa KianiView author publicationsYou can also search for this author in.

。大脑https://doi.org/10.1093/brain/awae166（2024）下载参考文献作者信息作者和附属机构数字评论神经病学http://www.nature.com/nrneurol/LisaKianiauthorsLisaKianiview作者出版物您也可以在中搜索此作者。

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Lisa Kiani.Rights and permissionsReprints and permissionsAbout this articleCite this articleKiani, L. Shared glial pathology in HD and schizophrenia.

丽莎·基亚尼。权利和许可打印和许可本文引用本文Kiani，L。在HD和精神分裂症中共享神经胶质病理学。

Nat Rev Neurol (2024). https://doi.org/10.1038/s41582-024-01010-5Download citationPublished: 06 August 2024DOI: https://doi.org/10.1038/s41582-024-01010-5Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

Nat Rev Neurol（2024）。https://doi.org/10.1038/s41582-024-01010-5Download引文发布日期：2024年8月6日OI：https://doi.org/10.1038/s41582-024-01010-5Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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