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register hereBackground: The application of autologous fat transplantation in facial lesions of patients with localized scleroderma has been reported in recent years.The authors report a case of worsening of active localized scleroderma after autologous fat transplantation. Methods: A man presented with neck and facial skin atrophy and pigmentation with a history of LS.

背景：近年来，已有报道称自体脂肪移植在局限性硬皮病患者面部病变中的应用。作者报告了一例自体脂肪移植后活动性局限性硬皮病恶化的病例。方法：一名患有LS病史的颈部和面部皮肤萎缩和色素沉着的男性。

Appearing 1.5 years ago, the lesion had progressively grown in size and shape. Consent is obtained after the patient is informed of the possible surgical risks during the active phase of the disease. He underwent autologous fat grafting into the right cheek with about 30 ml Coleman fat graft. Results: Skin dyspigmentation and atrophy progressively deteriorated one month into therapy, with slightly increased erythema and enlargement of the lesion.

出现在1.5年前，病变的大小和形状逐渐增加。在患者被告知疾病活动期可能存在的手术风险后，获得同意。他用约30毫升科尔曼脂肪移植物将自体脂肪移植到右脸颊。结果：治疗一个月后，皮肤色素沉着和萎缩逐渐恶化，红斑轻微增加，病变扩大。

Six months after the therapy, localized scleroderma related score worsened. Limitations: There are different factors such as systemic medications could affect the treatment of localized scleroderma by autologous fat transplantation. Meanwhile, considering the limitation of six-month follow-up period, obtaining long-term follow-up data is necessary to evaluate sustained outcomes and potential complications.Conlusion: More clinical research is needed to determine the time interval between disease inactivity and the application of any surgical procedures to avoid reactivation..

治疗6个月后，局部硬皮病相关评分恶化。局限性：有不同的因素，例如全身药物可能会影响自体脂肪移植治疗局限性硬皮病。同时，考虑到六个月随访期的局限性，获得长期随访数据对于评估持续结果和潜在并发症是必要的。结论：需要更多的临床研究来确定疾病不活动与任何外科手术的应用之间的时间间隔，以避免再激活。。