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NAD-dependent protein deacetylase sirtuin 2 (SIRT2) is a key protective mediator against cardiac ageing, according to a study in non-human primates. The study, published in Nature Aging, identifies the SIRT2–STAT3–CDKN2B axis as a crucial regulator of physiological cardiac ageing in primates and shows that overexpression of SIRT2 reverses natural cardiac ageing in mice, which suggests that SIRT2 modulation could be used to prevent cardiac ageing and ageing-related diseases..

根据对非人灵长类动物的研究，NAD依赖性蛋白脱乙酰酶sirtuin 2（SIRT2）是抗心脏衰老的关键保护介质。这项发表在《自然衰老》杂志上的研究确定SIRT2-STAT3-CDKN2B轴是灵长类动物生理性心脏衰老的重要调节因子，并表明SIRT2的过度表达逆转了小鼠的自然心脏衰老，这表明SIRT2调节可用于预防心脏衰老和衰老相关疾病。。

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Access Nature and 54 other Nature Portfolio journalsGet Nature+, our best-value online-access subscription24,99 € / 30 dayscancel any timeLearn moreSubscription info for Chinese customersWe have a dedicated website for our Chinese customers. Please go to naturechina.com to subscribe to this journal.Go to naturechina.comRent or buy this articlePrices vary by article typefrom$1.95to$39.95Learn morePrices may be subject to local taxes which are calculated during checkout.

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ReferencesOriginal articleYe, Y. et al. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nat. Aging https://doi.org/10.1038/s43587-023-00486-y (2023)Article

参考文献articleYe，Y。等人SIRT2通过使CDKN2B沉默的STAT3的脱乙酰化来抵消灵长类动物心脏衰老。纳特。老化https://doi.org/10.1038/s43587-023-00486-y（2023）条

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Download referencesAuthor informationAuthors and AffiliationsNature Reviews Cardiology http://www.nature.com/nrcardio/Irene Fernández-RuizAuthorsIrene Fernández-RuizView author publicationsYou can also search for this author in

下载参考文献作者信息作者和附属机构评论心脏病学http://www.nature.com/nrcardio/IreneFernández-RuizauthorsireneFernández-RuizView作者出版物YOU也可以在

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Irene Fernández-Ruiz.Rights and permissionsReprints and PermissionsAbout this articleCite this articleFernández-Ruiz, I. Sirtuin 2 protects against cardiac ageing.

IreneFernández-Ruiz。权利和许可本文的印刷和许可引用本文Fernández-Ruiz，I。Sirtuin 2可防止心脏衰老。

Nat Rev Cardiol (2023). https://doi.org/10.1038/s41569-023-00950-7Download citationPublished: 18 October 2023DOI: https://doi.org/10.1038/s41569-023-00950-7Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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