HAUPPAUGE, N.Y., Nov. 9, 2023 /PRNewswire/ -- Bio-Botanica, Inc., ® the one American company that has manufactured botanical extracts under one family for more than 50 years, has revealed the results of clinical trials indicating its proprietary botanical extract ingredient, Puresterol® (Pueraria mirifica), showed positive effects on the reduction of wrinkles when used in a face serum..

HAUPPAUGE，N.Y.，2023年11月9日/PRNewswire/-Bio-Botanica，Inc.，®一家在一个家庭生产植物提取物超过50年的美国公司已经揭示了临床试验的结果，表明其专有的植物提取物成分Puresterol®（Pueraria mirifica）在面部血清中使用时对减少皱纹有积极作用。。

Pueraria mirifica grows only in the rich soils of the high-altitude rainforests of Thailand and has been used by the Thais for a millennium as a rejuvenator and revitalizer to help offset some of the effects of aging.  Puresterol®, developed by Bio-Botanica, is the only patented, specially processed and highly active compound of Pueraria mirifica available in the market today (US Patent # 7,658,955, 2023)..

葛根仅生长在泰国高海拔雨林丰富的土壤中，并已被泰国人用作复兴和振兴千年，以帮助抵消一些衰老的影响。由Bio-Botanica开发的Puresterol®是目前市场上唯一获得专利，特别加工和高活性的Pueraria mirifica化合物（美国专利＃76589552023）。。

A third-party contract research organization (CRO) conducted clinical trials of Puresterol® in two different serum formulations under sponsorship by Bio-Botanica. In each trial, 21 subjects in different groups applied a serum in the morning and night for 28 days. The CRO used a state-of-the-art 3D structured-light scanner and software to precisely measure the area, length, and depth of crow's feet and forehead wrinkles at day 0 and day 28.

第三方合同研究组织（CRO）在Bio Botanica的赞助下，在两种不同的血清制剂中进行了Puresterol®的临床试验。在每个试验中，不同组中的21名受试者在早晨和晚上施用血清28天。CRO使用最先进的3D结构光扫描仪和软件在第0天和第28天精确测量乌鸦脚和前额皱纹的面积，长度和深度。

In addition, subjects were asked to evaluate their assessment of their treatment..

此外，要求受试者评估他们对治疗的评估。。

The first, placebo-controlled trial indicated Puresterol® in a serum had a statistically significant greater reduction of the depth of Crow's feet wrinkles when compared to placebo (p<0.05). The Puresterol® containing serum reduced the area of Crow's feet wrinkles (p<0.01), the length of Crow's feet wrinkles (p<0.01), and the depth of forehead wrinkles (p<0.01) from day 0 to day 28 in a statistically significant manner. 1 A follow up study with a different amount of Puresterol® in a serum indicated similar results with a statistically significant reduction in area of Crow's feet wrinkles (p<0.05), length of Crow's feet wrinkles (p<0.0001) and area of forehead wrinkles (p<0.05) from day 0 to day 28.

第一项安慰剂对照试验表明，与安慰剂相比，血清中的Puresterol®在统计学上显着减少了乌鸦脚皱纹的深度（p<0.05）。含有Puresterol®的血清减少了乌鸦脚皱纹的面积（p<0.01），乌鸦脚皱纹的长度（p<0.01），第0天至第28天的前额皱纹深度（p<0.01）具有统计学意义。1在血清中使用不同量的Puresterol®进行的随访研究表明，类似的结果显示乌鸦足皱纹面积（p<0.05），乌鸦足皱纹长度（p<0.0001）和前额面积有统计学意义的减少。从第0天到第28天皱纹（p<0.05）。

2 Additionally, over 80% of subjects in each of the Puresterol® groups indicated that at day 28, the Puresterol® based serum left the contours of their face appearing smoother. These results support a previous in vitro trial sponsored by Bio-Botanica® which found varied concentrations of Puresterol® inhibited Collagenase activity accordingly.

2此外，每个Puresterol®组中超过80%的受试者表示，在第28天，基于Puresterol®的血清使其面部轮廓变得更平滑。这些结果支持以前由BioBotanica®赞助的体外试验，该试验发现不同浓度的Puresterol®相应地抑制胶原酶活性。

3 Collagenase is an enzyme known to break down collagen and elastin and possibly lead to wrinkle formation.4.

3胶原酶是一种已知可分解胶原蛋白和弹性蛋白并可能导致皱纹形成的酶。

Puresterol® represents one of the many examples of Bio-Botanica's commitment to science and innovation in botanical based extracts since its founding in 1972 by Frank D'Amelio Senior. Unfortunately, this scientific research was one of the last pieces that Senior (as he was affectionately known), worked on prior to his untimely passing in 2021.

Puresterol®代表了自1972年Frank D'Amelio Senior创立以来生物植物学对植物提取物的科学和创新承诺的众多例子之一。不幸的是，这项科学研究是高级（如他深情所知）在2021年过早去世之前所做的最后一件作品之一。

Chief Marketing Officer, Dean D'Amelio, stated, 'My Father was proud of the work he did to develop botanical extracts based on traditional and modern scientific techniques. I'm glad we're able to share these results with the knowledge that customers will use Puresterol® to make great products that will help people around the world.'.

Dean D'Amelio首席营销官表示，“我父亲为他在传统和现代科学技术基础上开发植物提取物所做的工作感到骄傲。我很高兴我们能够分享这些结果，了解客户将使用Puresterol®制造能够帮助世界各地人们的优秀产品。

These studies support the use of Puresterol® as a cosmetic. Bio Botanica also offers Puresterol to companies for use in dietary, beauty from within, food, and beverage consumer packaged goods. To learn more about Puresterol® or Bio-Botanica, visit www.bio-botanica.com.

这些研究支持使用Puresterol®作为化妆品。Bio-Botanica还向公司提供纯甾醇，用于饮食，美容，食品和饮料消费品包装产品。要了解有关Puresterol®或Bio-Botanica的更多信息，请访问www.Bio-Botanica.com。

About Bio-Botanica, Inc.

关于生物植物学公司。

Bio-Botanica® is a family-owned and operated company, specializing in botanical extracts since its founding in 1972. Bio-Botanica® is a leading manufacturer of high-quality botanical extracts for personal care/cosmetics, food and beverage, flavor/fragrance, supplements, and dietary supplement industries.

BioBotanica®是一家家族拥有和经营的公司，自1972年成立以来专门从事植物提取物。BioBotanica®是个人护理/化妆品，食品和饮料，香料/香料，补充剂和膳食补充剂行业高品质植物提取物的领先制造商。

Located in Hauppauge, New York, Bio-Botanica's ® 160,00 square foot botanical extraction facility houses its own R&D, Microbiological, and QC laboratories. It has a state-of-the-art facility and experienced staff who work together on every project ensuring that Bio-Botanica ® successfully meets customer goals and objectives..

位于纽约Hauppauge的Bio-Botanica®160,00平方英尺植物提取设施拥有自己的研发，微生物和质量控制实验室。它拥有最先进的设施和经验丰富的员工，共同致力于每个项目，确保BioBotanica®成功满足客户的目标和目标。。

1 Ballester, J. C., 2020. Clinical Antiwrinkles Assessment of Face Serum MF-001-081 During 28 Days in 42 Volunteers, Valencia, Spain: Bionos Biotech, S.L. [Data on file at Bio-Botanica, Inc.].2 Gimeno, A. S., 2021. Clinical Antiwrinkles Assessment of 'Face Serum' w/ NE Puresterol RD7745, Valencia, Spain: Bionos Biotech, S.L.

1 Ballester，J。C.，2020年。42名志愿者在28天内对面部血清MF-001-081的临床抗皱纹评估，西班牙瓦伦西亚：Bionos Biotech，S.L。[存档于Bio-Botanica，Inc。的数据]2 Gimeno，A。S.，2021。“面部血清”的临床抗皱纹评估w/NE Puresterol RD7745，Valencia，Spain:Bionos Biotech，S.L。

[Data on file at Bio-Botanica, Inc.].3 Geetha, K. G., 2007. Report on In Vitro Anti Collagenase Activity for Puresterol, Bangalore, India: Sami Labs Ltd. [Data on file at Bio-Botanica, Inc.].4 Jenkins, G., 2002. Molecular Mechanisms of Ageing and Development. The Biology of Ageing, pp. 801-810.

[存档于Bio-Botanica，Inc。的数据]。3 Geetha，K。G.，2007年。关于印度班加罗尔Puresterol的体外抗胶原酶活性的报告：Sami Labs Ltd.[生物植物学公司存档的数据]，4 Jenkins，G.，2002。衰老和发展的分子机制。衰老生物学，第801-810页。

SOURCE Bio-Botanica Inc.

来源生物植物学公司。