Medically reviewed by Drugs.com.By Elana Gotkine HealthDay ReporterMONDAY, Nov. 13, 2023 -- The Predicting Risk of Cardiovascular Disease (CVD) Events (PREVENT) risk calculator estimates the risk for CVD, including heart failure, according to a methods paper and accompanying scientific statement published online Nov.

由Drugs.com.by Elana Gotkine HealthDay ReporterMONDAY医学评论，2023年11月13日-心血管疾病（CVD）事件预测风险（PREVENT）风险计算器根据方法估计CVD风险，包括心力衰竭论文和随附的科学声明在线发布11月。

10 in Circulation to coincide with the American Heart Association Scientific Sessions 2023, held from Nov. 11 to 13 in Philadelphia.Sadiya S. Khan, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues developed and validated the PREVENT equations among U.S. adults aged 30 to 79 years without known CVD.

10与费城11月11日至13日举行的美国心脏协会科学会议2023年一致。芝加哥西北大学芬伯格医学院的Sadiya S.Khan博士及其同事开发并验证了PREVENT方程在30至79岁的美国成年人中，没有已知的心血管疾病。

The derivation sample included individual-level participant data from 25 datasets with 3,281,919 participants; external validation was performed in 3,330,085 participants from 21 additional datasets. Predictors included traditional risk factors and estimated glomerular filtration rate (eGFR). The researchers identified 211,515 incident total CVD events during a mean follow-up of 4.8 years.

推导样本包括来自25个数据集的个人参与者数据，其中3281919名参与者；来自21个额外数据集的3330085名参与者进行了外部验证。预测因素包括传统危险因素和估计的肾小球滤过率（eGFR）。研究人员在平均随访4。8年期间确定了211515例CVD事件。

In external validation for CVD, the median C-statistics were 0.794 and 0.757 in female and male participants, respectively. For men and women, the calibration curves were 1.03 and 0.94, respectively. Similar estimates for discrimination and calibration were seen for atherosclerotic CVD- and heart failure-specific models.In a scientific statement, Khan and colleagues discuss the clinical implications of the PREVENT equations.

在CVD的外部验证中，女性和男性参与者的中位C统计量分别为0.794和0.757。对于男性和女性，校准曲线分别为1.03和0.94。对于动脉粥样硬化CVD和心力衰竭特异性模型，可以看到类似的鉴别和校准估计。在一份科学声明中，Khan及其同事讨论了PREVENT方程的临床意义。

The authors note that use of the equations allows 10- and 30-year risk estimates for total CVD (composite of atherosclerotic CVD and heart failure). The sex-specific risk equations include eGFR as a predictor and remove race from risk prediction estimates.'The PREVENT equations are a critical first step toward i.

作者指出，使用这些方程可以对总CVD（动脉粥样硬化性CVD和心力衰竭的复合）进行10年和30年的风险评估。性别特异性风险方程包括eGFR作为预测因子，并从风险预测估计中去除种族防止方程是朝向i的关键的第一步。