A recent study by Granton et al. in Cell investigates the role of exopolysaccharide (EPS) in Pseudomonas aeruginosa’s biofilm formation, immune evasion, and lung–brain signaling during pneumonia.1 This research significantly advances our understanding of how P. aeruginosa’s biofilms influence disease symptoms and suggests potential therapeutic strategies targeting the lung–brain axis to improve clinical outcomes in pneumonia patients.Long before the COVID-19 pandemic, social distancing from individuals suffering from severe respiratory tract infections has been an effective strategy to limit the transmission of airborne diseases.2 In their work, Granton et al.

Granton等人最近在细胞中进行的一项研究调查了胞外多糖（EPS）在肺炎期间铜绿假单胞菌生物膜形成，免疫逃避和肺-脑信号传导中的作用。1这项研究显着提高了我们对铜绿假单胞菌生物膜如何影响疾病症状的理解，并提出了针对肺-脑轴的潜在治疗策略，以改善肺炎患者的临床结果。早在新型冠状病毒肺炎大流行之前，与患有严重呼吸道感染的个体保持社会距离一直是限制空气传播疾病传播的有效策略。2 Granton等人在他们的工作中。

investigate the specific mechanisms by which the bacterium P. aeruginosa triggers symptoms of sickness in individuals suffering from pneumonia. Understanding these mechanisms is vital as they directly influence the spread of the disease. Bacterial strains causing less noticeable sickness may result in symptoms undetected by others, eventually enhancing the transmission of the pathogen.P.

研究铜绿假单胞菌引发肺炎患者疾病症状的具体机制。了解这些机制至关重要，因为它们直接影响疾病的传播。引起不太明显疾病的细菌菌株可能导致其他人未发现的症状，最终增强病原体的传播。第。

aeruginosa is a ubiquitous and highly adaptable bacterium, which can thrive in a huge variety of environments. It is capable of causing a range of infections in humans, particularly of the respiratory tract of individuals suffering from cystic fibrosis.3 Much of its ability to survive in diverse habitats is due to the bacterium’s ability to form strong biofilms, enabled by the production of two key exopolysaccharides: Pel (pellicle) and Psl (polysaccharide synthesis locus).In their study, the authors engineered two near isogenic strains of P.

铜绿假单胞菌是一种普遍存在且适应性强的细菌，可以在多种环境中繁殖。它能够引起人类的一系列感染，特别是患有囊性纤维化的个体的呼吸道感染[3]。它在不同生境中存活的能力很大程度上是由于细菌能够形成强大的生物膜，这是由于产生两种关键的胞外多糖：Pel（薄膜）和Psl（多糖合成基因座）。在他们的研究中，作者设计了两个近等基因的P菌株。

aeruginosa PAO1; one producing Pel and Psl at 37 °C (referred to as EPS+) and one unable to generate these components at any temperature (referred to as EPS−). The EPS+ strain formed biofilm-.

铜绿假单胞菌PAO1；一种在37°C下产生Pel和Psl（称为EPS+），另一种在任何温度下都不能产生这些成分（称为EPS-）。EPS+菌株形成生物膜-。

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Download referencesAcknowledgementsThis work was supported by Deutsche Forschungsgemeinschaft (German Research Foundation) under Germany’s Excellence Strategy EXC 2051 (Project-ID 390713860, “Balance of the Microverse”), - SFB1127/2 ChemBioSys— Project ID 239748522 as well as by the Werner Siemens Foundation.Author informationAuthors and AffiliationsDepartment of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Beutenbergstraße 11a, D-07745, Jena, GermanyShuaibing Zhang & Pierre StallforthInstitute for Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, D-07743, Jena, GermanyPierre StallforthCluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Fürstengraben 1, D-07743, Jena, GermanyPierre StallforthAuthorsShuaibing ZhangView author publicationsYou can also search for this author in.

下载参考文献致谢这项工作得到了德国研究基金会（Deutsche Forschungsgemeinschaft）根据德国卓越战略EXC 2051（项目ID 390713860，“微天平”），-SFB1127/2 ChemBioSys-项目ID 239748522以及Werner Siemens Foundation的支持。作者信息作者和所属机构莱布尼茨天然产物研究和感染生物学研究所古生物技术系-汉斯·克诺尔研究所，贝滕伯格斯特拉·11a，D-07745，耶拿，德国舒艾宾·张和皮埃尔·斯塔尔福廷有机化学和大分子化学研究所，弗里德里希·席勒大学耶拿，洪堡茨特拉·10，D-07743，耶拿，德国皮埃尔·斯塔尔福斯特卓越平衡大学，弗里德里希·席勒大学耶拿，弗斯滕格拉本1，D-07743，耶拿，德国皮埃尔·斯塔尔福斯特HauthorsShuaibing ZhangView作者出版物您也可以在中搜索此作者。

PubMed Google ScholarPierre StallforthView author publicationsYou can also search for this author in

PubMed Google ScholarPierre StallforthView作者出版物您也可以在

PubMed Google ScholarContributionsPierre Stallforth and Shuaibing Zhang wrote the manuscript and Shuaibing Zhang generated the figure. All authors have read and approved the article.Corresponding authorCorrespondence to

PubMed谷歌学术贡献Spierre Stallforth和Shuaibing Zhang撰写了手稿，Shuaibing Zhang生成了数字。所有作者都阅读并批准了这篇文章。对应作者对应

Pierre Stallforth.Ethics declarations

皮埃尔·斯塔福思。道德宣言

Competing interests

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The authors declare no competing interests.

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Reprints and permissionsAbout this articleCite this articleZhang, S., Stallforth, P. Biofilms and exopolysaccharides in Pseudomonas aeruginosa: pathogenesis, immune evasion, and lung–brain signaling during pneumonia.

转载和许可本文引用本文Zhang，S.，Stallforth，P。铜绿假单胞菌中的生物膜和胞外多糖：肺炎期间的发病机制，免疫逃避和肺-脑信号传导。

Sig Transduct Target Ther 9, 204 (2024). https://doi.org/10.1038/s41392-024-01902-4Download citationReceived: 07 May 2024Revised: 02 June 2024Accepted: 18 June 2024Published: 19 August 2024DOI: https://doi.org/10.1038/s41392-024-01902-4Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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