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register hereWe present an analysis of a case initially manifesting as bilateral horizontal gaze palsy, eventually diagnosed as multiple sclerosis (MS) with preclinical systemic lupus erythematosus (p-SLE). The patient, a 25-year-old male, exhibited restricted movement in both eyes. Cranial MRI revealed multiple demyelinating lesions; serum analyses indicated elevated levels of antinuclear antibodies (ANA), anti-Sm antibodies, and anti-nRNP antibodies.

在此登记我们对最初表现为双侧水平凝视麻痹的病例进行了分析，最终诊断为多发性硬化症（MS）伴临床前系统性红斑狼疮（p-SLE）。。头颅MRI显示多个脱髓鞘病变；血清分析表明抗核抗体（ANA），抗Sm抗体和抗nRNP抗体水平升高。

Oligoclonal bands were identified in the cerebrospinal fluid. Neurophysiological assessments demonstrated damage to the optic, auditory, and facial nerves. Given the clinical presentation, laboratory findings, and the progression of the disease, the final diagnosis was confirmed as MS associated with p-SLE.

。神经生理学评估显示视神经，听觉神经和面神经受损。鉴于临床表现，实验室检查结果和疾病进展，最终诊断为与p-SLE相关的MS。

The onset of MS with oculomotor disturbances is rare and may be easily confused with neuropsychiatric systemic lupus erythematosus (NPSLE). Furthermore, the differentiation of p-SLE from undifferentiated connective tissue disease (UCTD) in the early stages presents significant challenges. Early identification of risk factors and close monitoring of disease activity is crucial for an accurate diagnosis..

伴有动眼障碍的MS发作很少见，很容易与神经精神性系统性红斑狼疮（NPSLE）混淆。此外，在早期阶段，p-SLE与未分化结缔组织病（UCTD）的分化提出了重大挑战。早期识别危险因素并密切监测疾病活动对于准确诊断至关重要。。