SANTA FE, N.M.--(BUSINESS WIRE)--Cadence Molecular Sciences (OpenEye)—a business unit of Cadence Design Systems (Nasdaq: CDNS)—will provide OpenEye’s molecular design software to power the open-science AI-driven Structure-enabled Antiviral Platform (ASAP) Discovery Consortium in support of an innovative effort to rapidly develop antivirals to prevent future pandemics..

新墨西哥州圣达菲市——（商业新闻短讯）——Cadence分子科学（OpenEye）——Cadence Design Systems（Nasdaq:CDNS）的一个业务部门——将提供OpenEye的分子设计软件，为开放科学人工智能驱动的结构启用抗病毒平台（ASAP）发现联盟提供动力，以支持快速开发抗病毒药物以预防未来大流行的创新努力。。

John D. Chodera, PhD, a lab head at the Memorial Sloan Kettering Cancer Center (MSKCC), directs the researchers and software scientists building the computational chemistry infrastructure to support ASAP.

约翰·乔德拉博士是纪念斯隆·凯特琳癌症中心（MSKCC）的实验室主任，他指导研究人员和软件科学家建立计算化学基础设施以支持ASAP。

“Dr. Chodera and the ASAP scientists working with him will have access to OpenEye tools to help support the ASAP Discovery Consortium and antiviral drug research,” said Anthony Nicholls, PhD, corporate vice president, OpenEye, Cadence Molecular Sciences. “OpenEye’s software will aid in advancing therapeutics for under-researched diseases and to prepare for pandemics.”.

Cadence分子科学公司OpenEye公司副总裁AnthonyNicholls博士说：“Chodera博士和与他合作的ASAP科学家将可以使用OpenEye工具，以帮助支持ASAP发现联盟和抗病毒药物研究。”。“OpenEye的软件将有助于推进研究不足的疾病的治疗方法，并为大流行做好准备。”。

OpenEye’s Applications, Toolkits and Orion® platform—which include ROCS®, FastROCS™, BROOD, OMEGA, OEChemTK, Grapheme™, Nonequilibrium Switching (NES) Free Energy Calculations and other tools—enable computational chemists working with the ASAP Discovery Consortium to build a robust antiviral drug discovery pipeline using technology, structural biology, artificial intelligence (AI), machine learning and computational chemistry..

OpenEye的应用程序、工具包和Orion®平台，包括ROCS®、FastROCS™,育雏，欧米茄，OEChemTK，石墨烯™,非平衡转换（NES）自由能计算和其他工具使计算化学家能够与ASAP Discovery Consortium合作，利用技术、结构生物学、人工智能（AI）、机器学习和计算化学构建强大的抗病毒药物发现管道。。

“Open-science drug discovery against future pandemics is an essential public service,” said Chodera. “We are thrilled to have access to OpenEye’s industry-leading software in this effort. The OpenEye Toolkits have long been the backbone of our computer-aided drug discovery infrastructure, and access to the Orion NES Free Energy workflows allows us to run free energy calculations in mere hours.”.

Chodera说：“针对未来流行病的开放科学药物发现是一项重要的公共服务。”。“在这项工作中，我们很高兴能够使用OpenEye业界领先的软件。OpenEye工具包长期以来一直是我们计算机辅助药物发现基础设施的支柱，而访问Orion NES自由能工作流程使我们能够在短短数小时内运行自由能计算。”。

The ASAP Discovery Consortium is an Antiviral Drug Discovery (AViDD) U19 Center for Pathogens of Pandemic Concern funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), via a $68 million grant as part of the Antiviral Program for Pandemics (APP)..

ASAP发现联盟是一个抗病毒药物发现（AViDD）U19流行病病原体中心，由美国国立卫生研究院（NIH）下属的国家过敏与传染病研究所（NIAID）资助，作为大流行抗病毒计划（APP）的一部分，获得6800万美元的赠款。。

The NIH grant is for the initial three-year phase of the ASAP Discovery Consortium, which aims to deliver multiple drug candidates ready for evaluation in humans in the event of an ongoing or emerging pandemic threat. The project will maximize the use of an open science model that prioritizes global, equitable and affordable access to antiviral medicine, generating a wealth of antiviral data shared rapidly and openly..

美国国立卫生研究院拨款用于ASAP发现联盟的最初三年阶段，该联盟旨在提供多种候选药物，以便在发生持续或新出现的大流行威胁时进行人体评估。该项目将最大限度地利用开放科学模型，优先考虑全球，公平和负担得起的抗病毒药物获取，产生大量快速，公开共享的抗病毒数据。。

ASAP builds on the successes of the COVID Moonshot, a global, open-science collaboration that began in March 2020 and rapidly identified potent antivirals targeting the main protease of the SARS-CoV-2 virus. In July 2021, Moonshot received $11M in funding from the Wellcome Trust to pursue an accelerated preclinical program via the World Health Organization Access to COVID Tools Accelerator (ACT-A) and is working with the Drugs for Neglected Diseases Initiative (DNDi) to pursue clinical trials with a straight-to-generics model..

ASAP建立在新型冠状病毒登月计划（CovidMoonshot）成功的基础上，这是一项全球开放科学合作，始于2020年3月，并迅速确定了针对SARS-CoV-2病毒主要蛋白酶的有效抗病毒药物。2021年7月，Moonshot获得了惠康信托基金（Wellcome Trust）1100万美元的资金，通过世界卫生组织获得新型冠状病毒工具加速器（ACT-A）进行加速临床前项目，并与被忽视疾病药物倡议（DNDi）合作，以直接仿制药模式进行临床试验。。

The ASAP Discovery Consortium is led by PIs John Chodera (MSKCC), Alpha Lee (PostEra) and Peter Sjö (DNDi). ASAP partners include the Diamond Light Source (UK), the Weizmann Institute of Science (Israel), Medchemica (UK), Mount Sinai (USA), the Stanford University School of Medicine (USA) and the Fred Hutchinson Cancer Center (USA), as well as a vast global network of scientists and industry collaborators..

ASAP发现联盟由PIs John Chodera（MSKCC）、Alpha Lee（PostEra）和Peter Sjö（DNDi）领导。ASAP的合作伙伴包括钻石光源（英国）、魏茨曼科学研究所（以色列）、Medchemica（英国）、西奈山（美国）、斯坦福大学医学院（美国）和弗雷德·哈钦森癌症中心（美国），以及一个庞大的全球科学家和行业合作者网络。。

About ASAP

关于尽快

The AI-driven Structure-enabled Antiviral Platform (ASAP) Discovery Consortium uses artificial intelligence and computational chemistry to accelerate structure-based open-science antiviral drug discovery and deliver oral antivirals for pandemics with the goal of global, equitable and affordable access.

人工智能驱动的基于结构的抗病毒平台（ASAP）发现联盟使用人工智能和计算化学来加速基于结构的开放科学抗病毒药物的发现，并为大流行提供口服抗病毒药物，目标是全球，公平和负担得起的获取。

For more information about ASAP, including a complete list of diseases and drug targets and all open data that it has generated, visit https://asapdiscovery.org..

有关ASAP的更多信息，包括疾病和药物目标的完整列表以及它产生的所有开放数据，请访问https://asapdiscovery.org..

About Cadence

关于Cadence

Cadence is a pivotal leader in electronic design, building upon more than 30 years of computational software expertise. The company applies its underlying Intelligent System Design™ strategy to deliver software, hardware and IP that turn design concepts into reality. Cadence® customers are the world’s most innovative companies, delivering extraordinary electronic products from chips to boards to systems for the most dynamic market applications, including consumer, hyperscale computing, 5G communications, automotive, mobile, aerospace, industrial and healthcare.

Cadence是电子设计领域的关键领导者，拥有30多年的计算软件专业知识。该公司应用其底层智能系统设计™提供软件、硬件和IP的策略，将设计概念变为现实。Cadence®客户是世界上最具创新性的公司，为最具活力的市场应用（包括消费者、超规模计算、5G通信、汽车、移动、航空航天、工业和医疗保健）提供卓越的电子产品，从芯片到电路板再到系统。

For nine years in a row, Fortune magazine has named Cadence one of the 100 Best Companies to Work For. Learn more at www.cadence.com..

《财富》杂志连续九年将Cadence评为100家最佳工作公司之一。更多信息，请访问www.cadence.com。。

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