卫生与公众服务部订购OPVEE鼻喷雾剂，用于紧急芬太尼过量反应-动脉网

Health And Human Services Dept Orders OPVEE Nasal Spray For Emergency Fentanyl Overdose Response

benzinga 等信源发布 2024-08-27 09:02

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Indivior PLC INDV confirmed the first order of the OPVEE (nalmefene) nasal spray from the Biomedical Advanced Research and Development Authority (BARDA), which is the Department of Health and Human Services’ office responsible for procurement and development of medical countermeasures.

Indivior PLC INDV确认了生物医学高级研究与发展局（BARDA）的第一批OPVEE（纳美芬）鼻喷雾剂订单，该局是卫生与公众服务部负责采购和开发医疗对策的办公室。

The global pharmaceutical company focused on developing medicines to treat substance use disorders (SUD) and serious mental illnesses said that OPVEE is the first and only nasal rescue medicine specifically indicated for synthetic opioids like fentanyl.

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According to data from the Substance Abuse and Mental Health Services Administration, fentanyl is widespread in the illicit drug supply and more common than heroin. Overdose deaths are at historically high levels nationwide with over 108,000 people dying from overdose in 2022, as per data released by the Centers for Disease Control and Prevention (CDC).

根据药物滥用和心理健康服务管理局的数据，芬太尼在非法药物供应中广泛存在，比海洛因更常见。根据疾病控制和预防中心（CDC）发布的数据，全国过量服用药物的死亡率处于历史最高水平，2022年有超过108000人死于过量服用。

What's more, in the one-year period ending in January 2024, there were over 76,922 fatal overdoses..

更重要的是，在2024年1月结束的一年期间，有超过76922次致命的过量服用。。

With its first order of OPVEE, BARDA will be able to supplement local supplies of emergency opioid overdose medications for emergency rooms, ambulances, and other sites in the U.S. if medical countermeasure shortages occur during an emergency response.

如果在紧急响应期间出现医疗对策短缺，BARDA将通过其第一批OPVEE订单，能够为急诊室、救护车和美国其他场所补充当地供应的紧急阿片类药物过量药物。

“Providing communities with effective tools to address the fentanyl crisis is essential,” stated Richard Simkin, chief commercial officer and head of government affairs at Indivior. “This order of OPVEE has the potential to support the nation’s preparedness against potential biothreats and response efforts to reduce overdose deaths from fentanyl and other synthetic opioid poisonings.”.

Indivior首席商务官兼政府事务主管理查德·西姆金（RichardSimkin）表示：“为社区提供有效的工具来应对芬太尼危机至关重要。”。“OPVEE的这一命令有可能支持国家防范潜在的生物威胁，并做出反应，以减少芬太尼和其他合成阿片类药物中毒导致的过量死亡。”。

Read Also: Biden Administration Calls Fentanyl Laced With Xylazine ‘Emerging Threat,’ What Now?

读后：拜登政府称含有甲苯噻嗪的芬太尼为“新兴威胁”，现在怎么办？

$8.7M In Project BioSheild

BioSheild项目870万美元

BARDA's order of OPVEE comes some five months after Indivior announced the results from a pharmacodynamic study demonstrating the spray's rapid reverse of opioid-induced respiratory depression, the major cause of death due to opioid overdose. The findings showed that OPVEE reversed the respiratory depression produced by remifentanil – which is a synthetic opioid related to fentanyl – during the first 5 minutes following the administration..

。研究结果表明，OPVEE在给药后的前5分钟内逆转了瑞芬太尼（一种与芬太尼相关的合成阿片类药物）产生的呼吸抑制。。

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BARDA will use $8.7 million in Project BioShield designated funding for the initial procurement. The first option was exercised under the agreement with Indivior which was announced in December 2023. BARDA has the option to purchase additional OPVEE annually under Indivior vendor- managed inventory over the next nine years..

BARDA将使用870万美元的BioShield项目指定资金进行初始采购。根据2023年12月宣布的与Indivior的协议，行使了第一项选择权。BARDA有权在未来九年内根据个人供应商管理的库存每年购买额外的OPVEE。。

OPVEE would be used in prehospital settings (first responder/EMS) in accidental or intentional mass casualty situations.

OPVEE将用于意外或故意大规模伤亡情况下的院前环境（急救人员/EMS）。

This project was funded in whole or part with federal funds from the Department of Health and Human Services, Administration for Strategic Preparedness and Response and BARDA.

该项目全部或部分由卫生与公众服务部、战略准备与应对管理局和BARDA的联邦资金资助。