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EUR J CLIN NUTR：母体肠道微生物代谢产物与妊娠期糖尿病的相关性——来自原始病例对照研究、荟萃分析和孟德尔随机化的证据

EUR J CLIN NUTR：Association of maternal gut microbial metabolites with gestational diabetes mellitus——evidence from an original case-control study, meta-analysis, and Mendelian randomization

Nature 等信源发布 2024-09-02 14:58

可切换为仅中文

AbstractBackgroundThe associations of gut microbial metabolites, such as trimethylamine N-oxide (TMAO), its precursors, and phenylacetylglutamine (PAGln), with the risk of gestational diabetes mellitus (GDM) remain unclear.MethodsSerum samples of 201 women with GDM and 201 matched controls were collected and then targeted metabolomics was performed to examine the metabolites of interest.

摘要背景肠道微生物代谢物，如三甲胺N-氧化物（TMAO），其前体和苯乙酰谷氨酰胺（PAGln）与妊娠糖尿病（GDM）风险的关系尚不清楚。方法收集201名GDM女性和201名匹配对照的血清样本，然后进行靶向代谢组学检查目标代谢物。

Multivariable conditional logistic regression was applied to investigate the relationship between metabolites and GDM. Meta-analysis was performed to combine our results and four similar articles searched from online databases, and Mendelian randomization (MR) analysis was eventually conducted to explore the causalities.ResultsIn the case-control study, after dichotomization and comparing the higher versus the lower group, the adjusted odds ratio and 95% confidence interval of choline and L-carnitine with GDM were 2.124 (1.186–3.803) and 0.293 (0.134–0.638), respectively; but neutral relationships between TMAO, betaine, and PAGln with GDM were observed.

应用多变量条件logistic回归分析代谢物与GDM之间的关系。进行荟萃分析以结合我们的结果和从在线数据库中搜索的四篇类似文章，并最终进行孟德尔随机化（MR）分析以探索因果关系。结果在病例对照研究中，经过二分法并比较高组与低组后，胆碱和左旋肉碱与GDM的校正比值比和95%置信区间分别为2.124（1.186-3.803）和0.293（0.134-0.638）；但观察到TMAO，甜菜碱和PAGln与GDM之间的中性关系。

The following meta-analysis consistently revealed that L-carnitine was negatively associated with GDM. However, MR analyses showed no evidence of causalities.ConclusionsMaternal levels of L-carnitine were related to the risk of GDM in both the original case-control study and meta-analysis. However, we did not observe any genetic evidence to establish a causal relationship between this metabolite and GDM..

以下荟萃分析一致表明，左旋肉碱与GDM呈负相关。然而，MR分析显示没有因果关系的证据。结论在原始病例对照研究和荟萃分析中，母体左旋肉碱水平与GDM风险相关。然而，我们没有观察到任何遗传证据来确定这种代谢物与GDM之间的因果关系。。

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Fig. 1: The boxplot of gut microbial metabolites concentrations in GDM patients and controls.Fig. 2: Difference of gut microbial metabolites expressions in GDM patients and controls in the meta-analysis.

图1:GDM患者和对照组肠道微生物代谢物浓度的箱形图。图2：荟萃分析中GDM患者和对照组肠道微生物代谢物表达的差异。

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Data are available from the corresponding author upon reasonable request.

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Download referencesAcknowledgementsWe want to thank the participants and investigators of the Framingham Heart Study, the TwinsUK study, the Kooperative Gesundheitsforschung in der Region Augsburg study, and the FinnGen study.FundingJY is currently receiving grant from the National Natural Science Fund of China (grant number: 82273635).

下载参考文献致谢我们要感谢Framingham心脏研究，TwinsUK研究，Augsburg地区Kooperative Gesundheitsforschung研究和FinnGen研究的参与者和研究人员。FundingJY目前正在接受中国国家自然科学基金的资助（资助号：82273635）。

XZ is currently receiving grant from the Gusu Health Talents Program Training Project in Suzhou (grant number: GSWS2023064).Author informationAuthors and AffiliationsSuzhou Center for Disease Prevention and Control, Suzhou, ChinaMengxin Yao & Xiaoyan ZhuDepartment of Epidemiology and Health Statistics, Medical College of Soochow University, Suzhou, ChinaMengxin Yao, Yue Xiao, Yaling Ding, Fei Liang, Zhuoqiao Yang, Wenxin Ge & Jieyun YinNanjing Municipal Center for Disease Control and Prevention, Nanjing, ChinaYanqun SunDepartment of Geriatrics, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, ChinaBing ZhangTaicang Affiliated Hospital of Soochow University, The First People’s Hospital of Taicang, 58 Changsheng Road, Suzhou, ChinaQiuping Ma & Songliang LiuJiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, Medical College of Soochow University, Suzhou, ChinaLili Xin & Jieyun YinSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaXiaoyan ZhuAuthorsMengxin YaoView author publicationsYou can also search for this author in.

XZ目前正在接受苏州姑苏健康人才计划培训项目的资助（资助号：GSWS2023064）。作者信息作者和所属单位苏州市疾病预防控制中心姚梦欣、朱晓燕苏州大学医学院流行病学与健康统计系姚梦欣、岳晓、丁亚玲、梁飞、杨卓巧、葛文欣、尹洁云南京市疾病预防控制中心南京市南华理工大学广州市第一人民医院老年科苏州大学医学院重大慢性非传染性疾病预防与转化医学江苏省重点实验室，苏州，华中科技大学同济医学院公共卫生学院，武汉，。

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PubMed Google ScholarContributionsMY: Conceptualization, Software, Validation, Investigation, Writing - Original Draft. YX: Methodology, Investigation, Data Curation, Formal analysis. YS: Writing - Review & Editing. BZ: Writing - Review & Editing, Resources. YD: Investigation, Data Curation, Visualization.

PubMed谷歌学术贡献：概念化，软件，验证，调查，写作-原稿。YX：方法论，调查，数据管理，形式分析。YS：写作-评论和编辑。BZ：写作-评论和编辑，资源。YD：调查，数据管理，可视化。

QM: Conceptualization, Resources, Supervision. FL: Software, Investigation, Data Curation. ZY: Investigation, Data Curation. WG: Investigation, Data Curation, Visualization. SL: Resources, Supervision. LX: Conceptualization. JY: Conceptualization, Writing - Review & Editing, Supervision, Funding acquisition.

QM：概念化，资源，监督。FL：软件，调查，数据管理。ZY：调查，数据管理。WG：调查，数据管理，可视化。SL：资源，监督。LX：概念化。JY：概念化，写作-评论和编辑，监督，资金获取。

XZ: Resources, Writing - Review & Editing, Supervision, Funding acquisition.Corresponding authorsCorrespondence to.

XZ：资源，写作-评论和编辑，监督，资金获取。通讯作者通讯。

Jieyun Yin or Xiaoyan Zhu.Ethics declarations

尹洁云或朱晓燕。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Ethics approval and consent to participate

道德批准和同意参与

This original study was approved by the ethics committee of Soochow University and First People’s Hospital of Taicang. Written informed consent was obtained from all the patients.

这项原始研究得到了苏州大学伦理委员会和太仓市第一人民医院的批准。所有患者均获得书面知情同意书。

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et al. Association of maternal gut microbial metabolites with gestational diabetes mellitus: evidence from an original case-control study, meta-analysis, and Mendelian randomization..

母体肠道微生物代谢物与妊娠期糖尿病的关系：来自原始病例对照研究、荟萃分析和孟德尔随机化的证据。。

Eur J Clin Nutr (2024). https://doi.org/10.1038/s41430-024-01502-zDownload citationReceived: 05 December 2023Revised: 06 July 2024Accepted: 22 August 2024Published: 02 September 2024DOI: https://doi.org/10.1038/s41430-024-01502-zShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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