IntroductionHistiocytic neoplasms constitute a group of rare hematologic neoplasms characterized by the accumulation of neoplastic histiocytic/dendritic cells with associated inflammatory infiltrate [1]. Central nervous system (CNS) involvement of these neoplasms is associated with increased morbidity and mortality [2, 3].

。这些肿瘤的中枢神经系统（CNS）受累与发病率和死亡率增加有关[2，3]。

Contrast-enhanced brain and spine MRI is the current standard for evaluating for the presence of CNS disease and monitoring response to treatment [4]. Neurofilament light chain (NfL) is a recently identified biomarker of axonal degeneration that has been utilized in monitoring disease activity in a wide variety of neurologic diseases [5].

对比增强的大脑和脊柱MRI是评估中枢神经系统疾病存在和监测治疗反应的当前标准（4）。神经丝轻链（NfL）是最近发现的轴突变性生物标志物，已被用于监测各种神经系统疾病的疾病活动。

It has extensive potential clinical utility as it can be tested in blood. The aim of this study was to evaluate if elevated NfL in patients with histiocytic neoplasms is associated with CNS involvement and active CNS disease.MethodsEthics approval and consent to participateThis study was approved by the Institutional Review Board of Mayo Clinic, Rochester, Minnesota (Institutional Review Board 08-006647).

它具有广泛的潜在临床应用价值，因为它可以在血液中进行测试。这项研究的目的是评估组织细胞肿瘤患者NfL升高是否与中枢神经系统受累和活动性中枢神经系统疾病有关。方法该研究得到明尼苏达州罗切斯特梅奥诊所机构审查委员会（机构审查委员会08-006647）的批准和同意。

All patients gave written consent to the use of medical records and blood samples for research purposes. All methods were performed in accordance with relevant guidelines and regulations.Patient identificationAll patients seen at Mayo Clinic, MN with a diagnosis of histiocytic disorder by biopsy and appropriate clinical phenotype who were enrolled in the Center for Multiple Sclerosis and Autoimmune Neurology (CMSAN) or Lymphoma Specialized Program of Research Excellence (SPORE) and had stored blood available were included.

所有患者均书面同意将病历和血液样本用于研究目的。所有方法均按照相关指南和规定进行。患者鉴定所有在明尼苏达州梅奥诊所就诊的患者，通过活检和适当的临床表型诊断为组织细胞疾病，他们被纳入多发性硬化症和自身免疫神经病学中心（CMSAN）或淋巴瘤卓越研究专业计划（SPORE），并储存了可用的血液。

All cases were centrally reviewed by the Mayo Clinic-University of Alabama at Birmingham Histiocytosis Working Group to ensure appropriate classification [6]. Clinical data were abstracted by revi.

。临床数据由revi提取。

Data availability

数据可用性

Anonymized data used for this study are available on reasonable request to the corresponding author.

本研究使用的匿名数据可应通讯作者的合理要求提供。

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Download referencesAcknowledgementsThis publication was supported by Grant Number UL1 TR002377 from the National Center for Advancing Translational Sciences (NCATS) and R01NS113803 from the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

下载参考文献致谢本出版物得到了美国国家转化科学促进中心（NCATS）的资助号UL1 TR002377和美国国立卫生研究院（National Institutes of Health）的R01NS113803的支持。其内容仅由作者负责，不一定代表NIH的官方观点。

This work was made possible through the biospecimens made available in the Center for Multiple Sclerosis and Autoimmune Neurology (CMSAN) and Lymphoma Specialized Program of Research Excellence (SPORE).Author informationAuthors and AffiliationsDepartment of Neurology, Mayo Clinic, Rochester, MN, USASamantha A.

这项工作是通过多发性硬化症和自身免疫神经病学中心（CMSAN）和淋巴瘤专业卓越研究计划（SPORE）提供的生物样本实现的。作者信息作者和附属机构美国明尼苏达州罗切斯特市梅奥诊所神经病学系Samantha A。

Banks, Eoin P. Flanagan, Anastasia Zekeridou & W. Oliver TobinDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USAPaul Decker & Jeanette E. Eckel-PassowDepartment of Laboratory medicine and Pathology, Mayo Clinic, Rochester, MN, USAEoin P. Flanagan & Anastasia ZekeridouMayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN, USAEoin P.

班克斯，Eoin P.Flanagan，Anastasia Zekeridou＆W。Oliver TobinDepartment of Quantitative Health Sciences，Mayo Clinic，Rochester，MN，USAPULDECKER&Jeanette E.Eckel PASSOW Department of Laboratory medicine and Pathology，Mayo Clinic，Rochester，MN。

Flanagan, Anastasia Zekeridou & W. Oliver TobinDivision of Hematology, Mayo Clinic, Rochester, MN, USARonald S. Go, Jithma P. Abeykoon, N. Nora Bennani & Mithun V. ShahDivision of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL, USAGaurav GoyalDepartment of Radiology, at Mayo Clinic in Jacksonville, Jacksonville, FL, USAJason R.

弗拉纳根，Anastasia Zekeridou＆W。奥利弗·托布森血液学，梅奥诊所，罗切斯特，明尼苏达州，美国罗纳德·S·戈，吉特马·P·阿贝孔，N。Nora Bennani＆Mithun V.ShahDivision of Hematology Oncology，阿拉巴马大学伯明翰分校，伯明翰，AL，USAGaurav GOYAL放射科，位于美国佛罗里达州杰克逊维尔的梅奥诊所Jason R。

Young & Corrie R. BachDivision of Rheumatology, Mayo Clinic, Rochester, MN, USAMatthew J. KosterDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USARobert Vassallo & Jay H. RyuDivision of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USACaroline J. Davidge-PittsDivision of Laboratory Medicine-Hematopathology, Department of Pathology,.

Young＆Corrie R.BachDivision of Rheumatology，Mayo Clinic，Rochester，MN，USA Matthew J.KosterDivision of Pulmonary and Critical Care Medicine，Mayo Clinic，Rochester，MN，USA Robert Vassallo＆Jay H.RyuDivision of Endocrinology，Diabetes，and Nutrition，Mayo Clinic，Rochester，MN，。

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PubMed谷歌学术研讨会阿拉巴马大学伯明翰分校梅奥诊所组织细胞增多症工作组和梅奥诊所多发性硬化症和自身免疫神经病学中心Gaurav Goyal，Jason R.Young，Matthew J.Koster，Robert Vassallo，Jay H.Ryu，Caroline J.Davidge Pitts，Corrie R。

Bach, Aishwarya Ravindran, Julio C. Sartori Valinotti, N. Nora Bennani, Jithma P. Abeykoon, Mithun V. Shah, Karen L. Rech, Ronald S. Go & W. Oliver TobinContributionsSAB, PD, JEPE, and WOT were responsible for designing and reviewing the protocol. SAB, PD, JEPE, and WOT were responsible for writing the protocol and report.

巴赫（Bach），艾西瓦亚·拉文德兰（AishwaryaRavindran），朱利奥·C·萨托里·瓦利诺蒂（JulioC.SartoriValinotti），N。诺拉·本纳尼（NoraBennani）、吉特马·P·阿贝孔（JithmaP.Abeykoon）、米特洪诉沙阿（Mithunv.Shah）、凯伦·L·雷赫（KarenL.Rech）、罗纳德·S·戈（RonaldS.Go&W）。Oliver TobinContributionsSAB，PD，JEPE和WOT负责设计和审查该协议。SAB，PD，JEPE和WOT负责撰写协议和报告。

SAB and WOT were responsible for conducting research, extraction and analyzing data. SAB, EPF, AZ, RSG, JPA, GG, JRY, MJK, RV, JHR, CJDP, AR, JCSV, NNB, MVS, KLR, CRB, and WOT were responsible for reviewing cases and assigning accurate diagnoses. PD, EPF, AZ, RSG, JPA, GG, JRY, MJK, RV, JHR, CJDP, AR, JCSV, NNB, MVS, KLR, CRB, JEPE, and WOT provided feedback on the final report.Corresponding authorCorrespondence to.

SAB和WOT负责进行研究，提取和分析数据。SAB、EPF、AZ、RSG、JPA、GG、JRY、MJK、RV、JHR、CJDP、AR、JCSV、NNB、MVS、KLR、CRB和WOT负责审查病例并分配准确的诊断。PD、EPF、AZ、RSG、JPA、GG、JRY、MJK、RV、JHR、CJDP、AR、JCSV、NNB、MVS、KLR、CRB、JEPE和WOT对最终报告提供了反馈。对应作者对应。

W. Oliver Tobin.Ethics declarations

W、 奥利弗·托宾，《道德宣言》

Competing interests

相互竞争的利益

Dr. Banks was supported by Grant Number UL1 TR002377 from the National Center for Advancing Translational Sciences (NCATS), its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH; Dr Flanagan has served on advisory boards for Alexion, Genentech, Horizon Therapeutics and UCB.

Banks博士得到了国家转化科学促进中心（NCATS）的资助号UL1 TR002377的支持，其内容完全由作者负责，不一定代表NIH的官方观点；Flanagan博士曾担任Alexion、Genentech、Horizon Therapeutics和UCB的顾问委员会成员。

He has received research support from UCB, he has received speaker honoraria from Pharmacy Times, he received royalties from UpToDate, he is a site principal investigator in a randomized clinical trial of Rozanolixizumab for relapsing myelin oligodendrocyte glycoprotein antibody-associated disease run by UCB and is a site principal investigator and a member of the steering committee for a clinical trial of satralizumab for relapsing myelin oligodendrocyte glycoprotein antibody-associated disease run by Roche/Genentech, he has received funding from the NIH (R01NS113828), he is a member of the medical advisory board of the MOG project and is an editorial board member of Neurology, Neuroimmunology and Neuroinflammation, The Journal of the Neurological Sciences and Neuroimmunology Reports, a patent has been submitted on DACH1-IgG as a biomarker of paraneoplastic autoimmunity; Dr.

他获得了UCB的研究支持，他获得了《药房时报》的演讲者酬金，他从UpToDate获得了版税，他是UCB运营的罗扎诺利昔单抗复发性髓鞘少突胶质细胞糖蛋白抗体相关疾病随机临床试验的现场首席研究员，也是罗氏/基因泰克运营的satralizumab复发性髓鞘少突胶质细胞糖蛋白抗体相关疾病临床试验指导委员会的成员，他获得了NIH（R01NS113828）的资助，他是MOG项目医学顾问委员会的成员，也是编辑委员会的成员神经病学，神经免疫学和神经炎症成员，《神经科学和神经免疫学杂志》报道，DACH1 IgG作为副肿瘤自身免疫的生物标志物已提交专利；博士。

Zekeridou reports patents submitted for PDE10A-IgG, DACH1-IgG and Tenascin-R-IgG as biomarkers of neurological paraneoplastic autoimmunity, research funding from Roche not related to this project and consulting for Alexion Pharmaceuticals without personal compensation; Dr. Tobin reports receiving research funding from the National institutes of Health, Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology and Mallinckrodt Inc, he receives royalties from the publication of “Mayo Clinic Cases in Neuroimmunology” (OUP); Paul Decker, Ronald Go, Jithma Ab.

Zekeridou报告了PDE10A IgG，DACH1 IgG和腱生蛋白-R-IgG作为神经系统副肿瘤自身免疫的生物标志物提交的专利，罗氏的研究资金与该项目无关，并且咨询了Alexion Pharmaceuticals而没有个人补偿；托宾博士报告说，他获得了美国国立卫生研究院，梅奥多发性硬化症和自身免疫神经病学诊所中心以及Mallinckrodt Inc.的研究资金，他从《梅奥神经免疫学诊所病例》（OUP）的出版中获得了版税；保罗·德克（PaulDecker）、罗纳德·戈（RonaldGo）、吉思玛（Jithma Ab）。

Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Supplementary informationList of consortium membersSupplemental Figure 1. Changes in neurofilament light chain change across a disease course in one patient.Supplemental Figure.

Additional informationPublisher的注释Springer Nature在已发布的地图和机构隶属关系中的管辖权主张方面保持中立。补充信息联合体成员列表补充图1。一名患者在整个疾病过程中神经丝轻链的变化。补充数字。

Changes in neurofilament light chain change across a disease course in one patient.Supplemental Table 1. Demographic features and clinical features.Supplemental Table 2. Radiographic features of patients with central nervous system involvement of histiocytosis41408_2024_1118_MOESM6_ESM.docxSupplemental Table 3.

一名患者在整个疾病过程中神经丝轻链的变化。补充表1。人口统计学特征和临床特征。补充表2。中枢神经系统受累组织细胞增多症患者的影像学特征41408\U 2024\U 1118\U MOESM6\U ESM.docx补充表3。

Blood neurofilament light chain test in CNS histiocytosis with and without parenchymal involvement.41408_2024_1118_MOESM7_ESM.docxSupplemental Table 4. Blood neurofilament light chain in CNS histiocytosis with and without MRI enhancement within one month.Rights and permissions.

有和没有实质受累的中枢神经系统组织细胞增生症的血液神经丝轻链测试.41408\U 2024\U 1118\U MOESM7\U ESM.docx补充表4。中枢神经系统组织细胞增生症的血液神经丝轻链在一个月内有无MRI增强。权限和权限。

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Reprints and permissionsAbout this articleCite this articleBanks, S.A., Decker, P., Flanagan, E.P. et al. Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms.

转载和许可本文引用本文Banks，S.A.，Decker，P.，Flanagan，E.P。等人，中枢神经系统组织细胞肿瘤成人的血液神经丝轻链测量。

Blood Cancer J. 14, 153 (2024). https://doi.org/10.1038/s41408-024-01118-3Download citationReceived: 18 June 2024Revised: 24 July 2024Accepted: 29 July 2024Published: 05 September 2024DOI: https://doi.org/10.1038/s41408-024-01118-3Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

《血癌杂志》14153（2024）。https://doi.org/10.1038/s41408-024-01118-3Download引文收到日期：2024年6月18日修订日期：2024年7月24日接受日期：2024年7月29日发布日期：2024年9月5日OI：https://doi.org/10.1038/s41408-024-01118-3Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。复制到剪贴板。

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