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register hereThe relationship between serum uric acid (SUA) levels and prostate cancer (PCa) remains controversial. This cross-sectional study investigated the association between SUA levels and PCa incidence.: A total of 9,776 participants aged ≥40 from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 were included, 503 of whom had PCa.

在此登记血清尿酸（SUA）水平与前列腺癌（PCa）之间的关系仍存在争议。2007年至2020年，全国健康与营养调查（NHANES）共纳入9776名年龄≥40岁的参与者，其中503名患有PCa。

Weighted univariate logistic regression, multivariate logistic regression, and smooth-fitting curve analyses were used to analyze the association between SUA and PCa incidence. Concurrently, the fitted smoothing curves were used to explore the potential nonlinear relationships. If nonlinearity was observed, a recursive algorithm further calculated the inflection point.Results: Three models were used to analyze the correlation between SUA levels and PCa incidence.

使用加权单因素logistic回归，多因素logistic回归和平滑拟合曲线分析来分析SUA和PCa发病率之间的关联。同时，拟合的平滑曲线用于探索潜在的非线性关系。如果观察到非线性，则递归算法进一步计算拐点。结果：三个模型用于分析SUA水平与PCa发病率之间的相关性。

All regression models demonstrated a negative correlation between SUA levels and PCa incidence (Model 1: OR = 0.88, 95% CI=0.80-0.97; Model 2: OR = 0.87, 95% CI=0.80-0.96; Model 3: OR = 0.87, 95% CI=0.78-0.96). According to the trend test, with increasing SUA, the risk of PCa showed a downward trend (three models p for trend = 0.037, 0.015, 0.016).

所有回归模型均显示SUA水平与PCa发病率呈负相关（模型1:OR=0.88，95%CI=0.80-0.97；模型2:OR=0.87，95%CI=0.80-0.96；模型3:OR=0.87，95%CI=0.78-0.96）。根据趋势检验，随着SUA的增加，PCa的风险呈下降趋势（趋势的三个模型p=0.037、0.015、0.016）。

According to the subgroup analysis, a significant negative correlation between SUA and PCa was detected in individuals aged >60 years, non-Hispanic whites, those of other races, and those with hypertension. Moreover, the association between SUA and PCa followed a U-shaped curve among participants without hypertension, and the inflection point of SUA was 5.1 mg/dl.This cross-sectional study revealed a negative relationship between SUA levels and the risk of PCa, particularly in specific demographic groups.

根据亚组分析，在60岁以上的个体，非西班牙裔白人，其他种族和高血压患者中，SUA和PCa之间存在显着的负相关。此外，SUA和PCa之间的关联在没有高血压的参与者中呈U形曲线，SUA的拐点为5.1 mg/dl。这项横断面研究揭示了SUA水平与PCa风险之间的负相关关系，特别是在特定的人口群体中。

These findings offer a fresh perspective on the role of SUA in PCa patients, potentially pa.

这些发现为SUA在PCa患者（可能是pa）中的作用提供了新的视角。