Fibromuscular dysplasia (FMD) is a poorly understood blood vessel disorder that affects up to 5% of adults. Using a systems genetics approach, we identified an FMD-associated gene co-expression network that governs vascular cell function and developed a mouse model of FMD that recapitulates certain aspects of the human disease..

纤维肌肉发育不良（FMD）是一种知之甚少的血管疾病，影响多达5%的成年人。使用系统遗传学方法，我们确定了与口蹄疫相关的基因共表达网络，该网络控制血管细胞功能，并开发了口蹄疫小鼠模型，该模型概括了人类疾病的某些方面。。

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Fig. 1: Images of FMD and study flow diagram.

图1:FMD图像和研究流程图。

ReferencesLeadbetter, W. F. & Burkland, C. R. Hypertension in unilateral renal disease. J. Urol. 39, 611–626 (1938). This article provided the first description of FMD.Article

参考文献Leadbetter，W.F。＆Burkland，C.R。单侧肾脏疾病中的高血压。J、 乌洛尔。39611-626（1938）。本文提供了口蹄疫的第一个描述

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Persu, A. et al. Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia. Cardiovasc. Res. 118, 65–83 (2022). This is a recent review article on FMD.Article

Persu，A.等人。成人纤维肌肉发育不良的临床，分子和遗传学方面的最新进展。心血管。第118、65-83号决议（2022年）。这是一篇关于口蹄疫的最新评论文章

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Georges, A. et al. Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases. Nat. Commun. 12, 6031 (2021). This international GWAS meta-analysis identified five loci associated with FMD.Article

Georges，A。等人。纤维肌肉发育不良的遗传学研究确定了风险位点，并与常见心血管疾病共享遗传学。国家公社。126031（2021）。

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Bjorkegren, J. L. M., Kovacic, J. C., Dudley, J. T. & Schadt, E. E. Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J. Am. Coll. Cardiol. 65, 830–845 (2015). This review provides a critical look at GWASs and argues that systems biology holds great promise for understanding complex diseases.CAS .

Bjorkegren，J.L.M.，Kovacic，J.C.，Dudley，J.T.＆Schadt，E.E.全基因组重要基因座：它们有多重要？系统遗传学，以了解冠状动脉疾病和其他常见复杂疾病的遗传力。J、 美国科罗拉多州。心脏病。65830-845（2015）。。CAS。

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Download referencesAdditional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.This is a summary of: d’Escamard, V. et al. Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia.

下载参考其他信息出版商的注释Springer Nature对于已发布地图和机构隶属关系中的管辖权主张保持中立。这是d'Escamard，V。等人的总结。整合基因调控网络分析揭示了纤维肌肉发育不良的关键驱动基因。

Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00533-w (2024).Rights and permissionsReprints and permissionsAbout this articleCite this article Identifying a gene-regulatory network that drives fibromuscular dysplasia..

自然心血管。研究。https://doi.org/10.1038/s44161-024-00533-w（2024年）。权利和许可打印和许可本文引用这篇文章，确定了驱动纤维肌肉发育不良的基因调控网络。。

Nat Cardiovasc Res 3, 1033–1034 (2024). https://doi.org/10.1038/s44161-024-00534-9Download citationPublished: 13 September 2024Issue Date: September 2024DOI: https://doi.org/10.1038/s44161-024-00534-9Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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