AbstractObjectiveScanty data are available about neonatal systemic vascular resistances (SVR). We aim to provide reference values and nomograms for neonatal SVR.DesignMulticenter, cross-sectional,descriptive study performed in France and Italy. Neonates with complete hemodynamic stability were enrolled.

摘要目的可以获得有关新生儿全身血管阻力（SVR）的大量数据。我们旨在为新生儿SVR提供参考值和列线图。设计在法国和意大利进行的多中心，横断面，描述性研究。。

Non-invasive measurements of SVR by electrical cardiometry performed once, after the first 72 h and before the 7th day of postnatal age.ResultsWe studied 1094 neonates: SVR was correlated with gestational age (ρ = −0.55, adj-r = −0.46, p < 0.001) and birth weight (ρ = −0.59, adj-r = −0.45, p < 0.001) irrespective of newborn sex.

在出生后72小时和出生后第7天之前，通过电测心仪对SVR进行一次非侵入性测量。结果我们研究了1094名新生儿：SVR与胎龄（ρ=-0.55，adj-r=-0.46，p<0.001）和出生体重（ρ=-0.59，adj-r=-0.45，p<0.001）相关，与新生儿性别无关。

The relationships between SVR, gestational age and birth weight were represented by power equations and SVR was decreasing with increasing age and weight. Age- and weight-based SVR nomograms had optimal goodness-of-fit (non-linear R2 ≥0.74). Similar results were obtained for body surface indexed-SVR.ConclusionsIn hemodynamically stable neonates, SVR decrease with increasing gestational age and birth weight.

SVR，胎龄和出生体重之间的关系用幂方程表示，SVR随着年龄和体重的增加而降低。基于年龄和体重的SVR列线图具有最佳拟合优度（非线性R2≥0.74）。体表指数SVR获得了类似的结果。结论在血流动力学稳定的新生儿中，SVR随着胎龄和出生体重的增加而降低。

Specific gestational age and birth weight-based nomograms are provided for the clinical interpretation..

为临床解释提供了基于特定胎龄和出生体重的列线图。。

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Fig. 1: Relationship between systemic vascular resistances and gestational age or birth weight.Fig. 2: Systemic vascular resistance nomograms for preterm neonates based on gestational age or birth weight.Fig. 3: Systemic vascular resistance nomograms for term neonates based on gestational age or birth weight.Fig.

图1：全身血管阻力与胎龄或出生体重之间的关系。图2：基于胎龄或出生体重的早产儿全身血管阻力列线图。图3：基于胎龄或出生体重的足月新生儿全身血管阻力列线图。图。

4: Body surface indexed—systemic vascular resistance (SVRI): gestational age-based nomogram..

4： 体表指数全身血管阻力（SVRI）：基于胎龄的列线图。。

Data availability

数据可用性

Deidentified study dataset is available upon reasonable request to researchers who provide a methodologically sound proposal. Data requestors will need to sign a data transfer agreement and respect all relevant regulations.

经合理要求，可向提供方法合理建议的研究人员提供身份不明的研究数据集。数据请求者需要签署数据传输协议并遵守所有相关规定。

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Download referencesAuthor informationAuthors and AffiliationsDivision of Pediatrics and Neonatal Critical Care, “A. Béclère” Medical Center, Paris-Saclay University Hospitals, APHP, Paris, FranceValeria Bisceglie, Barbara Loi, Maria Elena Ferrari, Laura Vivalda & Daniele De LucaPhysiopathology and Therapeutic Innovation Unit-INSERM U999, Paris-Saclay University, Paris, FranceBarbara Loi & Daniele De LucaDivision of Neonatology and Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano “Niguarda”, Milan, ItalyOttavio Vitelli, Alice Proto & Stefano MartinelliPediatric Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyMatteo Di NardoAuthorsValeria BisceglieView author publicationsYou can also search for this author in.

下载参考文献作者信息作者和附属机构儿科和新生儿重症监护科，“A.Béclère”医学中心，巴黎萨克莱大学医院，APHP，巴黎，FranceValeria Bisceglie，Barbara Loi，Maria Elena Ferrari，Laura Vivalda＆Daniele De LucaPhysiopathology and Therapy INSERM U999，巴黎萨克莱大学，FranceBarbara Loi＆Daniele De LucaDivision of Neonatal重症监护室，ASST Grande Ospedale Metropolitano“Niguarda”，米兰，Italyttavio Vitelli，Alice Proto＆Steelli Fano MartinelliPediatric重症监护室，Bambino GesùChildren's Hospital，IRCCS，Rome，ItalyMatteo Di NardoAuthorsValeria BisceglieView作者出版物您也可以在中搜索这位作者。

PubMed Google ScholarBarbara LoiView author publicationsYou can also search for this author in

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PubMed Google ScholarContributionsVB and BL collected and interpreted the data, performed the statistical analysis and wrote the original draft of the manuscript. OV, AP, MEF, LV helped to collect and interpret the data and critically revised the manuscript. MDN and SM helped in data design and data interpretation and critically revised the manuscript.

PubMed Google ScholarContributionsVB和BL收集并解释了数据，进行了统计分析并撰写了手稿的原始草稿。OV，AP，MEF，LV帮助收集和解释了数据，并严格修改了手稿。MDN和SM帮助进行数据设计和数据解释，并对稿件进行了严格修订。

DDL conceived the study and designed it, performed the statistical analysis and prepared the figures and provide the study general supervision. All authors approved the final version of the manuscript.Corresponding authorCorrespondence to.

DDL构思并设计了这项研究，进行了统计分析，准备了数字，并提供了研究的一般监督。所有作者都批准了手稿的最终版本。对应作者对应。

Daniele De Luca.Ethics declarations

丹尼尔·德卢卡。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Ethics approval and consent to participate

道德批准和同意参与

French Critical Care Ethical Commission n.14/13 and Niguarda Hospital Institutional Ethical Board n.149674. The study respected the Helsinki Declaration.

法国重症监护伦理委员会n.14/13和尼瓜达医院机构伦理委员会n.149674。这项研究尊重了《赫尔辛基宣言》。

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Additional informationPublisher的注释Springer Nature在已发布地图和机构隶属关系中的管辖权主张方面保持中立。补充信息补充结果权利和许可Pringer Nature或其许可方（例如协会或其他合作伙伴）根据与作者或其他权利持有人的出版协议对本文拥有独家权利；本文接受稿件版本的作者自行存档仅受此类出版协议和适用法律的条款管辖。转载和许可本文引用本文Bisceglie，V.，Loi，B.，Vitelli，O。

et al. Neonatal reference values and nomograms of systemic vascular resistances estimated with electrical cardiometry..

等。用电测心法估计的新生儿参考值和全身血管阻力列线图。。

J Perinatol (2024). https://doi.org/10.1038/s41372-024-02115-xDownload citationReceived: 22 July 2024Revised: 03 September 2024Accepted: 05 September 2024Published: 17 September 2024DOI: https://doi.org/10.1038/s41372-024-02115-xShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

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