AbstractAlthough serum uric acid (UA) has been reported to be positively associated with increased arterial stiffness as evaluated by cardio-ankle vascular index (CAVI), UA also has an antioxidative effect that prevents endothelial damage. Therefore, the status of endothelial repair induced by endothelial damage might affect the correlation between UA and CAVI.

摘要尽管据报道血清尿酸（UA）与心踝血管指数（CAVI）评估的动脉僵硬度增加呈正相关，但UA也具有抗氧化作用，可防止内皮损伤。因此，内皮损伤诱导的内皮修复状态可能会影响UA和CAVI之间的相关性。

To clarify the correlation between UA and CAVI in relation to endothelial repair activity, we performed a cross-sectional study with 246 Japanese men aged 60–69 years undergoing a general health check-up. The analysis was stratified by the median circulating level of CD34-positive cells because circulating levels of CD34-positive cells could indicate the degree of endothelial repair activity.

为了阐明UA和CAVI与内皮修复活性之间的相关性，我们对246名60-69岁的日本男性进行了横断面研究，他们接受了全面的健康检查。通过CD34阳性细胞的中位循环水平对分析进行分层，因为CD34阳性细胞的循环水平可以指示内皮修复活性的程度。

Independent of known cardiovascular risk factors, among participants with high circulating levels of CD34-positive cells (0.95 cells/μL ≤), UA was significantly positively correlated with CAVI (standardized parameter estimate β = 0.23, p = 0.009), but not among participants with low circulating levels of CD34-positive cells (< 0.95 cells/μL) (β = 0.07, p = 0.445).

与已知的心血管危险因素无关，在CD34阳性细胞循环水平高（0.95细胞/μL≤）的参与者中，UA与CAVI显着正相关（标准化参数估计β=0.23，p=0.009），但在CD34阳性细胞循环水平低（0.95细胞/μL）的参与者中不存在（β=0.07，p=0.445）。

Independent of established cardiovascular risk factors, UA levels were significantly positively correlated with increased arterial stiffness only among participants with aggressive endothelial repair as evaluated by circulating levels of CD34-positive cells. These results might help clarify some background mechanisms related to endothelial activity..

独立于已确定的心血管危险因素，UA水平仅与具有侵袭性内皮修复的参与者的动脉僵硬度增加显着正相关，如通过CD34阳性细胞的循环水平所评估的。这些结果可能有助于阐明与内皮活性相关的一些背景机制。。

IntroductionIncreased arterial stiffness as evaluated by cardio-ankle vascular index (CAVI) is reported to be positively associated with oxidative stress1. Uric acid (UA) is an end product of purine metabolism. UA helps protect against oxidative stress2, but increased UA levels are associated with increased arterial stiffness as evaluated by CAVI3,4.

引言据报道，通过心踝血管指数（CAVI）评估的动脉僵硬度增加与氧化应激呈正相关1。尿酸（UA）是嘌呤代谢的最终产物。UA有助于防止氧化应激2，但如CAVI3,4所评估的，UA水平升高与动脉僵硬度增加有关。

UA is also known to activate inflammation5,6. Since inflammation increases CAVI7, UA might be positively associated with CAVI as an indicator of inflammation.Endothelial damage stimulates endothelial repair; the antioxidative effect and development of atherosclerosis are known endothelial repair processes.

UA也被称为激活炎症5,6。由于炎症增加了CAVI7，UA可能与CAVI呈正相关，作为炎症的指标。内皮损伤刺激内皮修复；抗氧化作用和动脉粥样硬化的发展是已知的内皮修复过程。

The antioxidative effect of UA is mainly intended to reduce the risk of endothelial damage. The development of atherosclerosis is associated with aggressive endothelial repair.Recently, endothelial progenitor cells such as CD34-positive cells were revealed to contribute to endothelial repair, including the development of atherosclerosis8,9.

UA的抗氧化作用主要旨在降低内皮损伤的风险。动脉粥样硬化的发展与侵袭性内皮修复有关。最近，内皮祖细胞如CD34阳性细胞被发现有助于内皮修复，包括动脉粥样硬化的发展8,9。

Circulating levels of CD34-positive cells could indicate the degree of endothelial repair activity when categorized based on the median value; individuals with high levels of CD34-positive cells have higher endothelial repair activity than individuals with low levels of CD34-positive cells10,11,12,13.Those studies suggest a positive correlation between UA and CAVI only in participants with high circulating levels of CD34-positive cells, who have active endothelial repair.

当根据中值分类时，CD34阳性细胞的循环水平可以指示内皮修复活性的程度；具有高水平CD34阳性细胞的个体比具有低水平CD34阳性细胞的个体具有更高的内皮修复活性10,11,12,13。这些研究表明UA和CAVI之间仅在具有高循环水平的CD34阳性细胞的参与者中呈正相关，具有活跃的内皮修复。

Therefore, we hypothesized that independent of known cardiovascular risk factors, UA is significantly positively correlated with CAVI among participants with high circulating CD34-positive cell count categorized based on the median value, but not among participants with low circulating CD34-positive count.To evaluate .

因此，我们假设，独立于已知的心血管危险因素，UA与CAVI在循环CD34阳性细胞计数高的参与者中显着正相关，而在循环CD34阳性计数低的参与者中则没有。进行评估。

Data availability

数据可用性

For our studies described in this review, we cannot publicly provide individual data due to participant confidentiality, according to ethical guidelines in Japan. Additionally, obtaining informed consent does not include a provision for publicity sharing data. Qualifying researchers may apply to access a minimal dataset.

根据日本的道德准则，对于本次审查中描述的研究，由于参与者的保密性，我们无法公开提供个人数据。此外，获得知情同意不包括宣传共享数据的规定。合格的研究人员可能会申请访问最小的数据集。

Please contact the office of data management at ritouken@vc.fctv-net.jp. Information for where the data request is also available at http://www.med.nagasaki-u.ac.jp/cm/..

请联系数据管理办公室ritouken@vc.fctv-net.jp.有关数据请求位置的信息，请访问http://www.med.nagasaki-u.ac.jp/cm/..

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Download referencesAcknowledgementsWe are grateful to staff from Goto city hall for their outstanding support.FundingThis study was supported by Grants-in-Aids for Scientific Research from Japan Society for the Promotion of Science (No.21H02575, No.22K06421). This funding source had no role in the design of this study and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results.Author informationAuthors and AffiliationsDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanYuji Shimizu, Hirotomo Yamanashi, Seiko Nakamichi & Takahiro MaedaEpidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, JapanYuji ShimizuDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanShin-Ya Kawashiri & Yasuhiro NagataLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanShin-Ya Kawashiri, Hirotomo Yamanashi, Naomi Hayashida, Yasuhiro Nagata & Takahiro MaedaDepartment of Islands and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanTakahiro MaedaDivision of Strategic Collaborative Research, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, JapanNaomi HayashidaAuthorsYuji ShimizuView author publicationsYou can also search for this author in.

下载参考文献致谢我们感谢后藤市政厅的工作人员提供的出色支持。。该资金来源在本研究的设计中没有任何作用，在执行，分析，解释数据或决定提交结果期间也不会发挥任何作用。作者信息作者和附属机构长崎大学生物医学科学研究生院普通医学系，长崎，日本清水久治，山梨博友，精工中町和前田高弘流行病学系，大阪公共卫生研究所公共卫生系，日本清水久治，长崎大学生物医学科学研究生院社区医学系，长崎，日本长崎Mi Hayashida，Yasuhiro Nagata＆Takahiro Maedad长崎大学生物医学研究生院岛屿与社区医学系，日本长崎，长崎，长崎，长崎，长崎，长崎，长崎，长崎大学原子弹疾病研究所战略合作研究部Kahiro Maedavision of Strategic Collaborative Research，Atomic Bomble Disease Institute，Nagasaki，JapanNaomi HayashidaAuthorsYuji ShimizuView Author Publications你也可以在中搜索这位作者。

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PubMed Google ScholarContributionsYS designed the study, performed the statistical analyses, interpreted the data, and drafted and revised the manuscript. YS, SY.K, HY, SN, NH, YN, and TM assisted with the study design, were involved in data collection, and checked the manuscript.

PubMed Google ScholarContributionsYS设计了这项研究，进行了统计分析，解释了数据，起草并修订了手稿。YS，SY。K，HY，SN，NH，YN和TM协助研究设计，参与数据收集，并检查手稿。

HY, YN, and TM participated in the study concept and checked the manuscript. TM was the general coordinator and designed the study.Corresponding authorCorrespondence to.

HY，YN和TM参与了研究概念并检查了手稿。TM是总协调员并设计了这项研究。对应作者对应。

Yuji Shimizu.Ethics declarations

清水余记。道德宣言

Competing interests

相互竞争的利益

The authors declare no competing interests.

作者声明没有利益冲突。

Ethical approval and consent to participants

对参与者的道德认可和同意

This study was approved by the Ethics Committee of Nagasaki University Graduate School of Biomedical Sciences (project registration number 14051404). All procedures involving human participants were performed in accordance with the ethical standards of the institution research committee and with the 1964 Helsinki Declaration and its later amendments for comparable ethical standards..

这项研究得到了长崎大学生物医学科学研究生院伦理委员会的批准（项目注册号14051404）。所有涉及人类参与者的程序均按照机构研究委员会的道德标准以及1964年《赫尔辛基宣言》及其后来的类似道德标准修正案进行。。

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Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.

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You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

根据本许可证，您无权共享源自本文或其部分的改编材料。本文中的图像或其他第三方材料包含在文章的知识共享许可证中，除非该材料的信用额度中另有说明。如果材料未包含在文章的知识共享许可中，并且您的预期用途不受法律法规的许可或超出许可用途，则您需要直接获得版权所有者的许可。

To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/..

要查看此许可证的副本，请访问http://creativecommons.org/licenses/by-nc-nd/4.0/..

Reprints and permissionsAbout this articleCite this articleShimizu, Y., Kawashiri, SY., Yamanashi, H. et al. Association between serum uric acid levels and cardio-ankle vascular index stratified by circulating level of CD34-positive cells among elderly Japanese men: a cross-sectional study.

转载和许可本文引用本文Shimizu，Y.，Kawashiri，SY.，Yamanashi，H。等人。血清尿酸水平与日本老年男性CD34阳性细胞循环水平分层的心踝血管指数之间的关联：横断面研究。

Sci Rep 14, 21965 (2024). https://doi.org/10.1038/s41598-024-72665-9Download citationReceived: 17 July 2024Accepted: 09 September 2024Published: 20 September 2024DOI: https://doi.org/10.1038/s41598-024-72665-9Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard.

Sci Rep 1421965（2024）。https://doi.org/10.1038/s41598-024-72665-9Download引文接收日期：2024年7月17日接受日期：2024年9月9日发布日期：2024年9月20日OI：https://doi.org/10.1038/s41598-024-72665-9Share本文与您共享以下链接的任何人都可以阅读此内容：获取可共享链接对不起，本文目前没有可共享的链接。。

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